Abstract:
:Natural products represent a rich source of bioactive compounds that have been historically used to obtain substances with great medicinal potential. The skin of anuran amphibians is a rich source of compounds with a wide range of biological activity. Alzheimer's disease (AD) is a complex disease associated with all kind of different pathways, making their simultaneous modulation necessary. Nowadays anti-AD treatments are focused on enzymatic inhibitors. Here in we report the activity of skin extracts from nine species from Argentina, belonging to three anuran families, as inhibitors of AChE, BChE and MAO-B enzymes. The extracts also showed antioxidant activities, acting as multi-target on four important pathways of AD.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Spinelli R,Aimaretti FM,López JA,Siano ASdoi
10.1080/14786419.2019.1591396subject
Has Abstractpub_date
2019-03-31 00:00:00pages
1-4eissn
1478-6419issn
1478-6427pub_type
杂志文章abstract::Development of natural nano-based plant-protection formulations represents an emerging phenomenon that has been widely improved for crops protection and for enhancing the efficiency and safety of pesticides. In the present study we isolated the essential oil from the fruits of Citrus trifoliata L. and investigated it ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1675063
更新日期:2019-10-09 00:00:00
abstract::Phytochemical investigation of Gymnocarpos decandrus roots lead to the isolation, characterization and evaluation of four compounds: the bis-coumarin daphnoretin, two biflavonoids: wikstrol A and wikstol B in addition to β-sitosterol glucoside. Their structures were established via spectroscopic data. The crude root e...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1607336
更新日期:2019-05-13 00:00:00
abstract::The CDC25 phosphatases regulate the cell division cycle by controlling the activity of cyclin-dependent kinases. While screening for inhibitors of phosphatases among natural products we repeatedly found that some polyprenyl-hydroquinones and polyprenyl-furans (furanoterpenoids) (furospongins, furospinosulins) were pot...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/1478641031000111534
更新日期:2004-02-01 00:00:00
abstract::Both enantiomers of the polyketide-derived lactone citreofuran (4) have been prepared. The enantiopure building blocks were obtained on a chemoenzymatic route ((S)-6) and by a chiral pool synthesis ((R)-6). The crucial step in the synthesis, a macrolactonization, was accomplished under Mitsunobu conditions. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/1478641031000137004
更新日期:2003-08-01 00:00:00
abstract::Extracts obtained from Cyrtocarpa procera Kunth were evaluated to determine their toxicity on Artemia salina Leach. All the extracts showed a significant activity. Bioguided fractionation of these extracts led to the isolation of beta-sitosterol and the identification of 1,3-propyl-dipentadecanoate, 3-hydroxypropyl-9-...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410500045358
更新日期:2006-01-01 00:00:00
abstract::Fusarium graminearum Schw. is associated with diseases in seeds and seedlings, mainly in maize, and causes damage to crops and food production. We determined the chemical compositions of essential oils from Pogostemon cablin (Blanco) Benth and Baccharis dracunculifolia DC., and evaluated their antioxidant and antifung...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1802267
更新日期:2020-08-06 00:00:00
abstract::A new triterpenoid saponin, silenoviscoside F (1), was isolated from the roots of Silene viscidula, together with three known saponins, dianchinenoside D (2), sinocrassuloside I (3) and sinocrassuloside II (4). The structure of compound 1 was elucidated by spectroscopic data, GC-MS and chemical methods. The structures...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.637216
更新日期:2012-11-01 00:00:00
abstract::The content of total polyphenols, chlorogenic, caffeic (CaA) and ferulic acids, and rutin, was investigated in plant organs of three introgression lines (IL7-3, IL10-1 and IL12-4) of Solanum pennellii in Solanum lycopersicum cv M82 and compared with that of cropped parental. Such study aims to evidence factors associa...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.704371
更新日期:2013-01-01 00:00:00
abstract::Antimicrobial potential of medicinal plants have been explored extensively these days. This study was carried out to evaluate the antibacterial potential from aerial parts of plant, called 'Annona senegalensis' and its constituents. Bioassay guided fractionation led to the isolation of four metabolites, (+)-catechin (...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1263847
更新日期:2017-08-01 00:00:00
abstract::In this study, the batch removal of copper(II) ions from an aqueous solution and wastewater using marine brown alga Sargassum sp. was investigated. Activated carbon prepared from Sargassum sp. by acid decomposition was also used for the removal of copper from the aqueous solution and wastewater. Activated carbon-prepa...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410903064915
更新日期:2010-03-01 00:00:00
abstract::Due to the increasing emergence of resistance of bacterial pathogens to current antibiotics, we have examined the marine fungi present in sea sediments obtained 200 m offshore to discover new antibacterial compounds active against multidrug-resistant bacteria. One strain, identified as Emericellopsis minima, was isola...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1344655
更新日期:2018-06-01 00:00:00
abstract::In a previous study, we evaluated the maternal and fetal safety of antimalarial herb Artemisia annua with artemisinin yield of 1.09%. Here, we attempted to ascertain the contraceptive claim of A. annua. Sexually matured female Wistar rats (180-220 g) were allotted into four study groups of six rats each. The control g...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.936016
更新日期:2014-01-01 00:00:00
abstract::Three new methylated flavonol glucosides: 3-methoxy-7-O-β-(6″-galloylgluco-pyranoside) quercetin (1), 3,4'-dimethoxy-7-O-β-(6″-galloyl-glucopyranoside) quercetin (2) and 3-methoxy-7-O-β-(6″-galloylgluco-pyranoside) kaempferol (3), in addition to six known flavonols, were isolated from the ethyl acetate extract of Fuma...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.778848
更新日期:2013-01-01 00:00:00
abstract::The present work describes the metabolites produced by a strain identified as Streptomyces youssoufiensis, whose secondary metabolites profile has not been studied so far. The crude ethyl acetate extract was analyzed by high performance liquid chromatography-electrospray ionization mass spectrometry, leading to the de...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1446014
更新日期:2019-01-01 00:00:00
abstract::In Lithuania, two species of the genus Fragaria L. (Rosaceae), F. vesca L. and F. viridis Weston, occur naturally in the wild and two others, F. moschata Weston and F. × ananassa Duchesne ex Rozier are found escaped from cultivation. The main objective of this study was to establish the variation pattern in the conten...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.660634
更新日期:2013-01-01 00:00:00
abstract::This study describes the seasonal composition and the antibacterial, antioxidant and anticholinesterase activity of the essential oil from Eugenia brasiliensis leaves. Analysis by using GC allowed the identification of 40 compounds. It was observed that the monoterpenes varied more (42%) than the sesquiterpenes (14%),...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.958736
更新日期:2015-02-01 00:00:00
abstract::The purpose of this study is to identify the quantity and antibacterial activity of the individual phenolic compounds in Brazilian red propolis. Quantitative analysis of the 12 phenolic compounds in Brazilian red propolis was carried out using reversed-phase high-performance liquid chromatography. The main phenolic co...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.898146
更新日期:2014-01-01 00:00:00
abstract::A new cinnamolyglycoflavonoid 3-cinnamoyltribuloside (1), its precursor tribuloside and two known flavonoid glycosides afzelin and astilbin were isolated from Heritiera littoralis Dryand (Sterculiaceae) ethanolic leaf extract. The dichloromethane leaf extract afforded two known pentacyclic triterpenoids, 3β-taraxerol ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.863202
更新日期:2014-01-01 00:00:00
abstract::A simple extraction procedure and HPLC method was developed to analyse the major and minor components of induced phytoalexins of elicited tissues (seeds) of chickpeas (Cicer arietinum L.) and peas (Pisum sativum L.) treated with a biotic elicitor (k-carrageenan) of Hypnea musciformis (red algae) from the Karachi coast...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.553952
更新日期:2011-08-01 00:00:00
abstract::A series of new thiazolyl chalcones, 1-[2-amino-4-methyl-1,3-thiazol-5-yl]-3-aryl-prop-2-en-1-one were prepared by piperidine mediated Claisen-Schmidt condensation of thiazolyl ketone with aromatic aldehyde. These chalcones on cyclisation gave 2-amino-6-(2-amino-4-methyl-1,3-thiazol-5-yl)-4-aryl-4H-pyridine-3-carbonit...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.536161
更新日期:2012-01-01 00:00:00
abstract::Methanolic extracts of 18 Thai plants from Doi Tung, the north of Thailand, were examined for brine shrimp lethality and antioxidative activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. In brine shrimp lethality, the highly toxic plant extracts were Mitrephora wangii (LC(50) 14.8 µg mL(-1)) and Hydrocotyle jav...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.534469
更新日期:2012-01-01 00:00:00
abstract::Triterpene saponins are throught to be potential anti-tumour agents in many cell types. This study aims to evaluate the cytotoxic activity and mechanism of a triterpene saponin, macranthoside B (MB), isolated from Lonicera macranthoides Hand.-Mazz. (Caprifoliaceae). A cell viability assay showed that MB inhibited cell...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786411003752086
更新日期:2011-02-01 00:00:00
abstract::Pigments synthesised by Chryseobacterium sp. kr6 growing on feather waste were extracted and characterised. The pigment extract was characterised by KOH test, UV-vis, CIELAB colour system, HPLC-DAD-MS, FTIR and its antioxidant capacity was evaluated. A positive bathochromic shift was observed when kr6 colonies or pigm...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1423304
更新日期:2019-06-01 00:00:00
abstract::The essential oil of Cyclospermum leptophyllum (Pers.) Sprague ex Britton and P. Wilson syn. Apium leptophyllum (Pers.) F. Muell. Ex Benth., family Apiaceae (Umbellifereae), was analysed by GC and GC-MS. The essential oil showed the presence of thymohydroquinone dimethyl ether (50.7%), thymol methyl ether (11.2%), γ-t...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.487190
更新日期:2011-03-01 00:00:00
abstract::The antimicrobial activities of plant extracts have formed the basis of many alternative medicines. In this context, the genus Schinus L. (Anacardiaceae), exhibits many traditional uses in medicine. However, a few studies on the antimicrobial properties of Schinus areira essential oils were conducted. The essential oi...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1675065
更新日期:2019-10-12 00:00:00
abstract::A sesquiterpenoid quinone, epi-ilimaquinone (1), and two sesquiterpene amino quinones, smenospongine (2) and glycinylilimaquinone (3), were isolated from the Fijian marine sponge Hippospongia sp. The structures of these compounds were determined by spectroscopic analysis. Compounds 1 and 3 were reported for the first ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.722086
更新日期:2013-01-01 00:00:00
abstract::A new anthraquinone (4) and three known anthraquinones (1-3) were isolated from Galium verum L. Their structures were identified as 1,3-dihydroxy-2-methylanthraquinone (1), physcion (2), 2-hydroxy-1,3-dimethoxyanthraquinone (3), 2,5-dihydroxy-1,3-dimethoxyanthraquinone (4) by means of chemical and spectroscopic analys...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410600921532
更新日期:2006-09-01 00:00:00
abstract::Two new eremophilanolides, sibiriolides A (1) and B (2), were isolated from the aerial parts of Xanthium sibiricum. The structures of the new compounds were identified as 4S,5R,7R,8R, 11R-2-oxo-1(10)-eremophilen-12,8-olide (1) and 4S,5R,7R,8R,11S-2-oxo-1(10)-eremophilen-12,8-olide (2) by HREIMS and NMR spectroscopic t...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410600906780
更新日期:2006-11-01 00:00:00
abstract::A new cholestane-type steroidal glycoside, solamyriaside A (1), was isolated from the fruits of Solanum myriacanthum Dunal (Solanaceae), along with two known steroidal glycosides, namely, solaviaside A (2) and aculeatiside A (3), and three known steroidal alkaloid glycosides, namely, solamargine (4), khasianine (5) an...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1781117
更新日期:2020-06-19 00:00:00
abstract::Pressafonin A (1) and pressafonin B (2), two new Michelia monoterpenic esters, have been isolated from Michelia compressa (Maxim.) Sargent var. formosana Kanehira (Magnoliaceae), and their structures are determined on the basis of spectroscopic analysis. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410903281774
更新日期:2010-04-01 00:00:00