A new steroidal glycoside from the fruits of Solanum myriacanthum.

abstract：:A facile, atom-economic synthesis of isoxazilidino withaferin, a novel hybrid of withaferin A, has been accomplished via two-step reaction of nitrone synthesis followed by nitrone 1,3-dipolar cycloaddition. The reaction is highly chemoselective (preferential reaction only on one of the two double bonds present on with...

journal_title：Natural product research

authors： Mandal R,Singh M,Krishnan AAV,Dahat YH,Bharitkar YP,Ravichandiran V,Hazra A

更新日期：2020-08-01 00:00:00

abstract：:Cardiac glycosides are used for treatment of irregular heartbeats, cardiac arrhythmia and congestive heart failures. In this research, digitoxin as a cardiac glycoside was identified and isolated for the first time in the world from Adonis aestivalis and investigated for its cytotoxic activity against cervical cancer ...

journal_title：Natural product research

authors： Hosseini M,Taherkhani M,Ghorbani Nohooji M

更新日期：2019-03-01 00:00:00

abstract：:Several Mediterranean shrubs, both autochthonous and naturalized, have been traditionally used as food, flavouring and/or spicing agents, and as phytopharmaceuticals. The interest around 'natural' and 'biological' products is steadily increasing in developed countries. Therefore, it seems reasonable to screen some shr...

journal_title：Natural product research

authors： Sanjust E,Mocci G,Zucca P,Rescigno A

更新日期：2008-05-20 00:00:00

abstract：:This study investigated the in vitro anticancer potential of phytochemical constituents isolated from the methanolic extract of Eriocephalus africanus. One flavanone (hesperidin) and two flavones (luteolin and apigenin) were isolated for the first time from the plant using column chromatography. Standard MTT assay was...

journal_title：Natural product research

authors： Magura J,Moodley R,Maduray K,Mackraj I

更新日期：2020-03-25 00:00:00

abstract：:Lycopus europaeus L. leaves water extract (LEL) was subjected to phytochemical analysis, and evaluated for its antibacterial and antioxidant effects. Antibacterial activity testing was performed on Staphylococcus aureus clinical strains from catheter-related and skin infections by broth microdilution test. LEL showed ...

journal_title：Natural product research

authors： Fialová S,Slobodníková L,Veizerová L,Grančai D

更新日期：2015-01-01 00:00:00

abstract：:Chemical investigation of Penthorum chinense resulted in the isolation of two neolignans (1 and 2) together with two known compounds (3 and 4). The structures of compounds 1 and 2 were determined by interpretation of spectroscopic data, and absolute configurations were made based on electronic circular dichroism (ECD)...

journal_title：Natural product research

authors： Huang D,Dong Z,Sun L,Chen W,Sun L

更新日期：2020-06-01 00:00:00

abstract：:The fungus showing homology with Nodulisporium by 28S ribosomal gene sequencing, which has been discovered as an endophyte on medicinal plant Nothapodytes foetida, was found to produce 45 and 5.5 microg of camptothecin (CPT) per gram of mycelia at bioreactor and at shake flask, respectively, which was further quantifi...

journal_title：Natural product research

authors： Rehman S,Shawl AS,Kour A,Sultan P,Ahmad K,Khajuria R,Qazi GN

更新日期：2009-01-01 00:00:00

abstract：:The crystal structure and unambiguous absolute configuration of meleagrin (1) isolated from fungus Emericella dentata Nq45 is reported herein to first time on the bases of single crystal X-ray diffraction. Together with 1, haenamindole (2), isorugulosuvine (3), secalonic acid D (4), ergosterol (5) and cerebroside A (6...

journal_title：Natural product research

authors： Hamed A,Abdel-Razek AS,Araby M,Abu-Elghait M,El-Hosari DG,Frese M,Soliman HSM,Stammler HG,Sewald N,Shaaban M

更新日期：2020-03-19 00:00:00

abstract：:Studies were made to increase the yield of piperine extraction using Naviglio Extractor® solid-liquid dynamic extractor (SLDE) from fruits of Piper longum. The effects of ratio w/v were investigated and optimised for the best method. The maximum yield of piperine (317.7 mg/g) from P. longum fruits was obtained in SLDE...

journal_title：Natural product research

authors： Gigliarelli G,Pagiotti R,Persia D,Marcotullio MC

更新日期：2017-01-01 00:00:00

abstract：:Two new flavonoid glycosides, kaempferol 3-O-α-L-rhamnopyranosyl (1→6) (3''-acetyl)-β-D-galactopyranoside 1 and kaempferol 3-O-α-L-arabinopyranosyl-5-O-α-L-rhamnopyranoside 2, along with six known ones 3-8 were isolated from the flowers of Vicia faba L. (Fabaceae). Methanol extract and the isolated compounds were test...

journal_title：Natural product research

authors： Allam AE,Nafady AM,Nakagawa T,Takemoto N,Shimizu K

更新日期：2018-08-01 00:00:00

abstract：:A new benzophenone glycoside, mitraphenone A (1), together with three known compounds (2-4) were isolated from the leaves of the traditionally used medicinal plant Mitracarpus villosus (Rubiaceae) collected in Nigeria. A combination of one- and two-dimensional NMR spectroscopic and mass spectrometric measurements were...

journal_title：Natural product research

authors： Ngwoke KG,Orame N,Liu S,Okoye FBC,Daletos G,Proksch P

更新日期：2017-10-01 00:00:00

abstract：:In this computational study, geometric factors are calculated by applying semi-empirical methods (PM3) that support experimental evidence from this lab where bryostatins can bind trivalent iron with six Fe-O bonds forming an octahedral geometry. The geometric factors are calculated for all 20 structures (Fe3+ bound to...

journal_title：Natural product research

authors： Manning TJ,Thomas J,Osiro S,Smith J,Abadi G,Noble L,Phillips D

更新日期：2008-03-20 00:00:00

abstract：:Fructose feeding induces a rise in blood pressure in normal rats that is associated with insulin resistance, hyperinsulinemia, hyperglycaemia, hypercholesterolaemia and hypertriglyceridaemia. We have examined the effect of chronic administration of A-HRS (100 and 300 mg kg⁻¹; p.o.) isolated from Hibiscus rosa sinensis...

journal_title：Natural product research

authors： Mohan M,Khade B,Shinde A

更新日期：2012-01-01 00:00:00

abstract：:The emphasis of the present study is to evaluate a natural product and the potential microbicide activity using a dual chamber infection method. Malva sylvestris extracts and fractions were screened for anti-HIV activity by measuring the virus-antibody neutralization. Plant extracts with strong antiviral activity work...

journal_title：Natural product research

authors： Benso B,Rosalen PL,Pasetto S,Marquezin MCS,Freitas-Blanco V,Murata RM

更新日期：2019-08-20 00:00:00

abstract：:Two alkaloids of the furoquinoline-type were isolated from Ammi majus L.; a new one and was identified as 4-hydro-7-hydroxy-8-methoxyfuroquinoline (1), and the other was isolated for the second time from nature and was identified as 4-hydro-7-hydroxy-8-prenyloxyfuroquinoline (2). The structures of the isolated compoun...

journal_title：Natural product research

authors： Mohammed MM,El-Sharkawy ER

更新日期：2017-03-01 00:00:00

abstract：:A new compound decomposed from ginkgolide B(GB) is discovered and identified by MS and UV spectrum. It is the dehydrate of GB, which was named as ginkgolide K before. Differently, it cannot exist independently, but only in equilibrium with GB. It is found first time that 3-hydroxy is active in some solvent. ...

journal_title：Natural product research

authors： Yuan C,Pan J,Hu X

更新日期：2008-01-01 00:00:00

abstract：:Teucrium marum and T. subspinosum have been extracted with different polarity solvents, each crude extract was analysed with (1)H-NMR to compare the overall metabolic component. The polar extracts showed antioxidant activity in vitro. Verbascoside and arabinosyl-verbascoside were isolated and identified. Their concent...

journal_title：Natural product research

authors： Poli F,Serrilli AM,Scartezzini P,Muzzoli M,Maxia A,Ballero M,Serafini M,Bianco A

更新日期：2007-10-01 00:00:00

abstract：:A new monoterpenoid indole alkaloid compound (1) and six known monoterpenoid indole alkaloids compounds (2-7) were isolated from the barks of Voacanga africana Staph. The structures were established by spectral analysis as ibogamine-16-carboxylic acid,17,20-didehydro-5,6-dioxo-10-methoxy-methyl ester (1), voacamine (2...

journal_title：Natural product research

authors： Chen HM,Yang YT,Li HX,Cao ZX,Dan XM,Mei L,Guo DL,Song CX,Dai Y,Hu J,Deng Y

更新日期：2016-01-01 00:00:00

abstract：:The chloroformic extract of the aerial parts of Ferula behboudiana (Umbelliferae) afforded four new polysulphane derivatives: 1-sec-butyl-2-[(E)-3-(methylthio)prop-1-enyl]disulphane (1), 1-sec-butyl-2-[(Z)-3-(methylthio)prop-1-enyl]disulphane (2), 1-[(E)-3-(methylthio)prop-1-enyl)-2-(1-(methylthio)propyl]disulphane (3...

journal_title：Natural product research

authors： Yousefi M,Mohammadi M,Habibi Z,Shafiee A

更新日期：2010-09-01 00:00:00

abstract：:One new xanthone, chryxanthone C (1), together with four known analogues (2-5), were isolated from the cultures of Paecilamyces sp. TE-540, an endophytic fungus obtained from the leaves of Nicotiana tabacum L. The structure of 1 was elucidated by comprehensive spectral analysis including HRESIMS and 1D/2D NMR, which w...

journal_title：Natural product research

authors： Li XQ,Dong QJ,Xu K,Yuan XL,Liu XM,Zhang P

更新日期：2020-10-04 00:00:00

abstract：:Phytochemical investigation of the twigs of Garcinia nobilis led to the isolation of a new xanthone, named l-hydroxy-2,5-dimethoxyxanthone (1), together with 15 known compounds (2-16). The structures of the new and known compounds were established by means of spectroscopic methods and by comparison with previously rep...

journal_title：Natural product research

authors： Fouotsa H,Tatsimo SJ,Neumann B,Michalek C,Mbazoa CD,Nkengfack AE,Sewald N,Lannang AM

更新日期：2014-01-01 00:00:00

abstract：:Meliquercifolins A (1), and B (2), two new coumarins are bearing an acetophenone derivative were isolated from the leaves of Melicope quercifolia along with three known compounds, melicodenines E (3), F (4) and I (5). Structures of two new compounds were identified based on spectroscopic analyses (UV, HR-ESI-MS, 1 D a...

journal_title：Natural product research

authors： Saputri RD,Tjahjandarie TS,Tanjung M

更新日期：2019-07-22 00:00:00

abstract：:In this study, phytochemical composition, antioxidant, enzyme inhibition and cytotoxic activities of methanol and dichloromethane (DCM) extracts of Bougainvillea glabra (B. glabra) flowers were investigated. Methanol extract was found to have higher total bioactive contents and UHPLC-MS analysis of methanol extract re...

journal_title：Natural product research

authors： Saleem H,Htar TT,Naidu R,Zengin G,Ahmad I,Ahemad N

更新日期：2020-09-01 00:00:00

abstract：:A phytochemical reinvestigation of the whole plant of Euphorbia segetalis yielded five tetracyclic triterpenes: 3beta-hydroxy-cycloart-25-en-24-one (1), cycloart-25-ene-3beta,24-diol (2), cycloart-23-ene-3beta,25-diol (3), lanosta-7,9(11),24-trien-3beta-ol (4) and lanosta-7,9(11),24(31)-trien-3beta-ol (5). beta-acetox...

journal_title：Natural product research

authors： Madureira AM,Ascenso JR,Valdeira L,Duarte A,Frade JP,Freitas G,Ferreira MJ

更新日期：2003-10-01 00:00:00

abstract：:Natural products, especially plants, have been investigated as sources of new substances with antimicrobial properties. In this context, the Myrcia genus is extensively researched for presenting such activities. This work aims to evaluate the antifungal, antibacterial, and antioxidant properties of extracts and fracti...

journal_title：Natural product research

authors： Gatto LJ,Veiga A,Gribner C,Moura PF,Rech KS,Murakami FS,Dias JFG,Miguel OG,Miguel MD

更新日期：2020-07-13 00:00:00

abstract：:Five flavonoids were isolated from the ethyl acetate fraction of leaves of Sophora secundiflora; formononetin (1), 5-hydroxy-4'-methoxyflavone (2), genistein (3), 5-hydroxy-8-(1-hydroxy-1-methyl-ethyl)-2-(4-hydroxyphenyl)-4H-furo-[2, 3-h]-chromen-4-one (4) and ononin (5). Additionally, LC-ESI-MS/MS analysis of the eth...

journal_title：Natural product research

authors： Aly SH,Elissawy AM,Fayez AM,Eldahshan OA,Elshanawany MA,Singab ANB

更新日期：2020-07-22 00:00:00

abstract：:The use of a matrix solid-phase dispersion (MSPD) process to extract polyphenols from hawthorn (Crataegus oxyacantha L.) a deciduous shrub with an expected rich phytochemical profile, has been evaluated. MSPD extracts of fruits and leaves have an outstanding content of polyphenols, although the particular phenolic pro...

journal_title：Natural product research

authors： Benabderrahmane W,Lores M,Lamas JP,Benayache S

更新日期：2018-05-01 00:00:00

abstract：:The chemical composition of the methanol extract obtained from Araucaria cunninghamii Sweet. bark was determined by GC-MS analysis with its antioxidant and antibacterial potential, for the first time. A total of 73 compounds were identified and the extract was strongly characterised by Viridiflorene; Androstan-17-one,...

journal_title：Natural product research

authors： Kumar P,Sati SC,Khulbe K,Pant P,Tripathi AN,Sarvendra K

更新日期：2020-11-29 00:00:00

abstract：:The iridoidic composition of Stachys glutinosa L. was examined in comparison with the results obtained in the phytochemical studies on S. corsica Pers. The presence of the known harpagide and acetyl-harpagide were showed together with that of a new di-glycosidic iridoid. The structure of this new compound, the 5-allos...

journal_title：Natural product research

authors： Serrilli AM,Ramunno A,Piccioni F,Serafini M,Ballero M,Bianco A

更新日期：2006-05-20 00:00:00

abstract：:Chemical investigation of Trogopterus faeces has led to the isolation of seven flavonoids. Their structures were elucidated by chemical and spectral analyses. In an anticoagulative assay, three kaempferol coumaroyl rhamnosides had significant antithrombin activity. This is the first report on the occurrence of flavono...

journal_title：Natural product research

authors： Yang NY,Tao WW,Duan JA

更新日期：2010-11-01 00:00:00