Artemisia annua as a possible contraceptive agent: a clue from mammalian rat model.

Abstract:

:In a previous study, we evaluated the maternal and fetal safety of antimalarial herb Artemisia annua with artemisinin yield of 1.09%. Here, we attempted to ascertain the contraceptive claim of A. annua. Sexually matured female Wistar rats (180-220 g) were allotted into four study groups of six rats each. The control group received normal saline, while the A. annua-treated groups received 100, 200 and 300 mg/kg of A. annua for 2 weeks, followed by mating with proven fertile males (1:1). The rats were allowed to carry the pregnancy to term. At birth and weaning periods, selected reproductive outcome and fertility indices were determined. The results showed that A. annua significantly reduced litter size, reproductive outcome and fertility indices compared with the control (p <  0.05). These results imply that A. annua could serve as a prospective contraceptive agent in addition to its antimalarial activity.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Abolaji AO,Eteng MU,Ebong PE,Dar A,Farombi EO,Choudhary MI

doi

10.1080/14786419.2014.936016

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

2342-6

issue

24

eissn

1478-6419

issn

1478-6427

journal_volume

28

pub_type

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