Malva sylvestris derivatives as inhibitors of HIV-1 BaL infection.

Abstract:

:The emphasis of the present study is to evaluate a natural product and the potential microbicide activity using a dual chamber infection method. Malva sylvestris extracts and fractions were screened for anti-HIV activity by measuring the virus-antibody neutralization. Plant extracts with strong antiviral activity working in nanomolar or picomolar range can be used to enhance the activity of synthetic compounds and work as anti-HIV agents. The aqueous fraction (AF) of M. sylvestris demonstrated antiviral activity in a model with epithelial and blood cell lines. The AF showed an effective antiviral potential on the TZM-bl cells with reduction scores higher than 60% of infectivity. Quantification of p24 in the supernatant of the co-culture model demonstrated a reduction in the number of viral particles after AF treatment (p < 0.05). Cytokines were quantified and all signaling inflammatory markers; IL1-alpha, IL-beta, IL-6, IL-8 and GM-CSF (p < 0.05) were modulated by positive control and AF treatments. In particular, IL-6 had lower levels of expression in Malva groups when compared to the Zidovudine positive control group. Natural occurring derivatives of M. sylvestris demonstrated to work inhibiting reverse transcriptase enzyme action. M. sylvestris contains highly potential anti-HIV-1 BaL components and may be considered a potential source for new formulations in the development of topical microbicides.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Benso B,Rosalen PL,Pasetto S,Marquezin MCS,Freitas-Blanco V,Murata RM

doi

10.1080/14786419.2019.1619720

subject

Has Abstract

pub_date

2019-08-20 00:00:00

pages

1-6

eissn

1478-6419

issn

1478-6427

pub_type

杂志文章
  • A new furofuran lignan from Piper terminaliflorum Tseng.

    abstract::The chemical investigation of whole plants Piper terminaliflorum Tseng led to the isolation of one new furofuran lignan, 7-methoxyasarinin (1), along with three known amide alkaloids (2-4) as N-3,5-dimethoxy-4-hydroxycinnamoylpyrrole (2), dihydropipercide (3) and 1-[(2E,4E,9E)-10-(3,4-Methylenedioxyphenyl)-2,4,9-undec...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1350671

    authors: Liu T,Liang Q,Zhang XM,Huang SY,Xu WH

    更新日期:2018-02-01 00:00:00

  • Isopimarane-type diterpenoids from Croton laevigatus.

    abstract::A new isopimarane-type diterpenoid, crolaevinoid A, along with four known analogues was isolated from the twigs and leaves of Croton laevigatus. The structures of the isolated compounds were established on the basis of NMR and MS spectroscopic analyses. The isolated compounds were examined the antibacterial activities...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1596096

    authors: Li MY,Han ZZ,Liu LF,Wu XZ,Huang WJ,Wang K,Yang F,Yuan CS

    更新日期:2020-10-01 00:00:00

  • A new coumarin from the fruits of Coutarea hexandra.

    abstract::A new 5-O-beta-D-glucopyranosyl-4-(4-hydroxyphenyl)-7-methoxy-2H-chromen-2-one (1), together with four known compounds, one coumarin, 5-O-beta-D-galactopyranosyl-4-(4-hydroxyphenyl)-7-methoxy-2H-chromen-2-one (2) and three cucurbitacins, 23,24-dihydrocucurbitacin F (3), 23,24-dihydro-25-acetylcucurbitacin F (4) and 2-...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410701371116

    authors: Olmedo D,Rodríguez N,Vásquez Y,Solís PN,López-Pérez JL,Feliciano AS,Gupta MP

    更新日期:2007-06-01 00:00:00

  • Rapid biosynthesis of silver nanoparticles using Crotalaria verrucosa leaves against the dengue vector Aedes aegypti: what happens around? An analysis of dragonfly predatory behaviour after exposure at ultra-low doses.

    abstract::Aedes aegypti is a primary vector of dengue, a mosquito-borne viral disease infecting 50-100 million people every year. Here, we biosynthesised mosquitocidal silver nanoparticles (AgNP) using the aqueous leaf extract of Crotalaria verrucosa. The green synthesis of AgNP was studied by UV-vis spectroscopy, SEM, EDX and ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2015.1074230

    authors: Murugan K,Sanoopa CP,Madhiyazhagan P,Dinesh D,Subramaniam J,Panneerselvam C,Roni M,Suresh U,Nicoletti M,Alarfaj AA,Munusamy MA,Higuchi A,Kumar S,Perumalsamy H,Ahn YJ,Benelli G

    更新日期:2016-01-01 00:00:00

  • Valorization of raw materials from agricultural industry for astaxanthin and β-carotene production by Xanthophyllomyces dendrorhous.

    abstract::Waste deriving from food and agro-industries is a growing problem in our modern society. In order to reduce food waste and its associated impacts over the environment and public health, innovative strategies for the conversion of food wastes in added value products are studied. Whey is one of the prominent waste deriv...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1385024

    authors: Gervasi T,Pellizzeri V,Benameur Q,Gervasi C,Santini A,Cicero N,Dugo G

    更新日期:2018-07-01 00:00:00

  • 3.5-scFv-β-lactamase, a new protein detector of picric acid, the highly nitrated organic explosive.

    abstract::A new protein detector of 2,4,6-trinitrophenol (TNP, picric acid) is concisely reported herein for the first time. In brief, the gene of a specific scFv fragment, namely 3.5, was fused separately with the gene of β-lactamase and, subsequently, expressed in the periplasmic space of Escherichia coli, affording in such a...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1860977

    authors: Simonovic M,Mix T,Glumac M,Pejin B

    更新日期:2020-12-18 00:00:00

  • Comparison of antioxidant, anticholinesterase, and antidiabetic activities of three curcuminoids isolated from Curcuma longa L.

    abstract::Antioxidant, anticholinesterase and antidiabetic activities of three curcuminoids isolated from the Curcuma longa were simultaneously tested and compared in this study. The highest antioxidant power was detected for curcumin with the applied methods. The drug potentials of curcuminoids for Alzheimer's disease were con...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1299727

    authors: Kalaycıoğlu Z,Gazioğlu I,Erim FB

    更新日期:2017-12-01 00:00:00

  • Antioxidative and anticarcinogenic activities of methylpheophorbide a, isolated from wheat grass (Triticum aestivum Linn.).

    abstract::Methylphophorbide a (MPa) has been isolated from the ethanol extract of the wheat grass plant. Its antioxidative efficacy is evaluated by hydroxyl radical scavenging activities and reducing capacity which are significantly up regulated in comparison with aqueous extract of the plant. The compound shows iron-binding ca...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2015.1022775

    authors: Das P,Mandal S,Gangopadhyay S,Das K,Mitra AG,Dasgupta S,Mukhopadhyay S,Mukhopadhyay A

    更新日期:2016-01-01 00:00:00

  • New polysulphanes from aerial parts of Ferula behboudiana Rech. f. & Esfand.

    abstract::The chloroformic extract of the aerial parts of Ferula behboudiana (Umbelliferae) afforded four new polysulphane derivatives: 1-sec-butyl-2-[(E)-3-(methylthio)prop-1-enyl]disulphane (1), 1-sec-butyl-2-[(Z)-3-(methylthio)prop-1-enyl]disulphane (2), 1-[(E)-3-(methylthio)prop-1-enyl)-2-(1-(methylthio)propyl]disulphane (3...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410903458273

    authors: Yousefi M,Mohammadi M,Habibi Z,Shafiee A

    更新日期:2010-09-01 00:00:00

  • The antioxidant power of horseradish, Armoracia rusticana, underlies antimicrobial and antiradical effects, exerted in vitro.

    abstract::Armoracia rusticana (AR) was tested for antimicrobial and antioxidants power. The compound demonstrated to inhibit fish pathogens such as Vibrio anguillarum, V. harvey, V. alginolyticus, Aeromonas hydrophila, A. salmonicida, Photobacterium damselae subspecie piscicida, Tenacibaculum marinum and Pseudomonas anguillisep...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1517121

    authors: Manuguerra S,Caccamo L,Mancuso M,Arena R,Rappazzo AC,Genovese L,Santulli A,Messina CM,Maricchiolo G

    更新日期:2020-06-01 00:00:00

  • A new squalene derivative from Physalis angulata L. (Solanaceae).

    abstract::Physalis angulata is an annual herb which has tremendous medicinal uses. The antioxidant activity of the whole plant extract of Physalis angulata was investigated using DPPH radical scavenging activity. Purified compounds were isolated using column chromatography method. Their structures were determined using various ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1844691

    authors: Odusina BO,Onocha PA

    更新日期:2020-11-23 00:00:00

  • Two new benzoic acid derivatives from endophytic fungus Aspergillus versicolor.

    abstract::Two new benzoic acid derivatives, named methyl(S)-3-hydroxy-4-(2- hydroxy -6-methylheptan-2-yl)benzoate (1) and 2-hydroxy-3-(6- hydroxy-6-methylhept-1-en-2-yl)benzoic acid (2), were isolated from the ethanol extract of an endophytic fungus Aspergillus versicolor derived from the medicinal plant Euphorbia royleana. The...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1777121

    authors: Ye Y,Chen Y,Hou Y,Yu H,Zhu L,Sun Y,Zhou M,Chen Y,Dong M

    更新日期:2020-06-11 00:00:00

  • Loliolide in marine algae.

    abstract::Loliolide content was determined in 13 marine algae including red, brown and green algae collected from the Black Sea, the Dardanelles and the Aegean Sea. Identification and quantification were performed by gas chromatography-mass spectrometry. The loliolide content in green alga is 1.76 microg g(-1), ranges from 0.14...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410802076069

    authors: Percot A,Yalcin A,Aysel V,Erduğan H,Dural B,Güven KC

    更新日期:2009-01-01 00:00:00

  • LC determination and pharmacokinetic study of the main phenolic components of Portulaca oleracea L. extract in rat plasma after oral administration.

    abstract::This study investigated the pharmacokinetics of hesperidin (HP), ferulic acid (FA) and p-coumaric acid (CA) in rat plasma after oral administration of Portulaca oleracea L. extract (POE). The plasma concentrations were determined by HPLC with vitexin-2″-O-rhamnoside (VR) as internal standard. The calibration curves we...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2011.648193

    authors: Cheng Z,Wang D,Zhang W,Du Y,Wang Y,Zhai Y,Ying X,Kang T

    更新日期:2012-01-01 00:00:00

  • Oleanane triterpenoids from Rubia philippinensis and their inhibitory effect on 20-HETE synthesis.

    abstract::A new oleanane triterpenoid (2) was isolated from the roots of Rubia philippinensis. The structure of 2 was determined by analysis of HRMS and NMR data and identified as a rubiprasin analogue, 16β-hydroxyrubiprasin B. Four related known compounds were also encountered which include rubiprasin B (1), maslinic acid (3),...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1645656

    authors: Quan KT,Min BG,Hwang IH,Choi YJ,Kim SK,Na M

    更新日期:2019-07-25 00:00:00

  • Isolation and structural characterization of a non-diketopiperazine phytotoxin from a potato pathogenic Streptomyces strain.

    abstract::Two Streptomyces spp. strains responsible for potato common scab infections in Uruguay which do not produce diketopiperazines were identified through whole-genome sequencing, and the virulence factor produced by one of them was isolated and characterized. Phylogenetic analysis showed that both pathogenic strains can b...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1511554

    authors: Lapaz MI,López A,Huguet-Tapia JC,Pérez-Baldassari MF,Iglesias C,Loria R,Moyna G,Pianzzola MJ

    更新日期:2019-10-01 00:00:00

  • SPME-GC-MS analysis of commercial henna samples (Lawsonia inermis L.).

    abstract::The aim of this work was to provide a characterisation of volatile constituents from different commercial batches of henna (Lawsonia inermis) leaves of different geographic origin. Headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS) was used for the purpose. A tota...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2015.1055491

    authors: Mengoni T,Peregrina DV,Censi R,Cortese M,Ricciutelli M,Maggi F,Di Martino P

    更新日期:2016-01-01 00:00:00

  • Chemistry of α-mangostin. Studies on the semisynthesis of minor xanthones from Garcinia mangostana.

    abstract::α-Mangostin is the major prenylated xanthone from Garcinia mangostana and it has been used also in recent times as starting material for the semisynthetic preparation of various biologically active derivatives. Its structure is characterised by the presence of few functional groups amenable to chemical manipulations, ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2014.986729

    authors: Morelli CF,Biagiotti M,Pappalardo VM,Rabuffetti M,Speranza G

    更新日期:2015-01-01 00:00:00

  • Uvarmicranones A and B, two new benzoquinones and cytotoxic constituents from the stems of Uvaria micrantha (A. DC.) Hook. f. & Thomson.

    abstract::Two novel benzoquinones, uvarmicranones A (1) and B (2), along with 15 known compounds (3 - 17) were isolated from the stems of Uvaria micrantha (Annonaceae). Their structures were elucidated by analyses of NMR and high-resolution mass data. A plausible biosynthetic pathway of uvarmicranone A (1) via Diels-Alder cyclo...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1824221

    authors: Boonsombat J,Thongnest S,Kheawchaum S,Mahidol C,Ruchirawat S,Prawat H

    更新日期:2020-09-22 00:00:00

  • Antioxidant xanthones from Cratoxylum cochinchinense.

    abstract::A new xanthone named cratoxylumxanthone A (1), together with five known compounds: dulcisxanthone B (2), alpha-mangostin (3), beta-mangostin (4), 2-geranyl-1,3,7-trihydroxy-4-(3-methylbut-2-enyl)xanthone (5) and tectochrystin (6), was isolated from Cratoxylum cochinchinense stems. The structure of new compound was cha...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410601102033

    authors: Phuwapraisirisan P,Udomchotphruet S,Surapinit S,Tip-Pyang S

    更新日期:2006-12-01 00:00:00

  • Phytochemical profiling, antioxidant, enzyme inhibition and cytotoxic potential of Bougainvillea glabra flowers.

    abstract::In this study, phytochemical composition, antioxidant, enzyme inhibition and cytotoxic activities of methanol and dichloromethane (DCM) extracts of Bougainvillea glabra (B. glabra) flowers were investigated. Methanol extract was found to have higher total bioactive contents and UHPLC-MS analysis of methanol extract re...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1543684

    authors: Saleem H,Htar TT,Naidu R,Zengin G,Ahmad I,Ahemad N

    更新日期:2020-09-01 00:00:00

  • Turmerin, the antioxidant protein from turmeric (Curcuma longa) exhibits antihyperglycaemic effects.

    abstract::A wide range of proteinaceous inhibitors are present in plants to protect themselves from hydrolytic enzymes. In this study, turmerin, a water-soluble peptide in turmeric rhizomes, was evaluated for its inhibitory potential against glucosidase and its antioxidant (AO) capacity. Turmerin inhibited α-amylase and α-gluco...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2011.589386

    authors: Lekshmi PC,Arimboor R,Raghu KG,Menon AN

    更新日期:2012-01-01 00:00:00

  • A new cyclopeptide alkaloid from Clematis Florida.

    abstract::One new 14-membered ring cyclopeptide alkaloid, plenane A (1), along with six known compounds (2-7), was isolated from the roots of Clematis florida. Their structures were elucidated by means of NMR spectroscopic analysis and mass spectrometry. In addition, their anti- inflammatory effects on lipopolysaccharide-induce...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1809399

    authors: Wu Y,Zhang YF,Zhang HT,Ma XH,Yang NN,Feng SB,Zhong TH,Zhang YH

    更新日期:2020-08-18 00:00:00

  • Phenolic compounds from Glycyrrhiza pallidiflora Maxim. and their cytotoxic activity.

    abstract::Twenty-one phenolic compounds (1-21) including dihydrocinnamic acid, isoflavonoids, flavonoids, coumestans, pterocarpans, chalcones, isoflavan and isoflaven, were isolated from the roots of Glycyrrhiza pallidiflora Maxim. Phloretinic acid (1), chrysin (6), 9-methoxycoumestan (8), isoglycyrol (9), 6″-O-acetylanonin (19...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2016.1188094

    authors: Shults EE,Shakirov MM,Pokrovsky MA,Petrova TN,Pokrovsky AG,Gorovoy PG

    更新日期:2017-02-01 00:00:00

  • Fatty acid composition of seeds of some species of Nepeta L.

    abstract::The fatty acid compositions of Nepeta viscida, N. cilicica, N. crinita, N. nuda ssp. glandulifera and N. aristata were analyzed by GC/MS. The main free fatty acids were found as linolenic acid (49.8-58.5%), linoleic acid (10.9-23.5%), oleic acid (11.5-19.2%), palmitic acid (5.2-6.8%) and stearic acid (2.0-3.7%) and, t...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410601129473

    authors: Kiliç T,Dirmenci T,Gören AC

    更新日期:2007-05-01 00:00:00

  • Histochemical investigation of Cochlospermum regium (Schrank) Pilg. leaves and chemical composition of its essential oil.

    abstract::Essential oil from Cochlospermum regium (Schrank) Pilg. leaves (CR-EO) has been extracted by hydrodistillation; we analysed the CR-EO by gas chromatography coupled with mass spectrometry. We also conducted histochemical analysis on cross-sections of the central vein of young and adult leaves. A total of 32 compounds w...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2013.879133

    authors: Inácio MC,Paz TA,Bertoni BW,Vieira MA,Marques MO,Pereira AM

    更新日期:2014-01-01 00:00:00

  • Phenanthrene and dihydrophenanthrene derivatives from Dioscorea communis with anticholinesterase, and antioxidant activities.

    abstract::Five phenanthrene and two dihydrophenanthrene derivatives were isolated from the diethyl ether extract of fresh rhizomes of Dioscorea communis (L.), among them a phenanthrentriol 1 reported for the first time from Dioscoreaceae family and two dihydrophenanthrene derivatives 6 and 7 reported also for the first time fro...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1468328

    authors: Boudjada A,Touil A,Bensouici C,Bendif H,Rhouati S

    更新日期:2019-11-01 00:00:00

  • Identification and screening of active components from Ziziphora clinopodioides Lam. in regulating autophagy.

    abstract::This study investigated the flavonoid constituents of a traditional Chinese medical plant Ziziphora clinopodioides Lam. by using ultra-performance liquid chromatography coupled with quadruple time-of-flight mass spectrometry and screened the active components in regulating autophagy.Normal rat kidney (NRK) cells trans...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1452002

    authors: Zhang XM,An DQ,Guo LL,Yang NH,Zhang H

    更新日期:2019-09-01 00:00:00

  • Semi-synthesis of a novel hybrid isoxazolidino withaferin via chemoselective and diastereoselective 1,3-dipolar nitrone cycloaddition reaction.

    abstract::A facile, atom-economic synthesis of isoxazilidino withaferin, a novel hybrid of withaferin A, has been accomplished via two-step reaction of nitrone synthesis followed by nitrone 1,3-dipolar cycloaddition. The reaction is highly chemoselective (preferential reaction only on one of the two double bonds present on with...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1582045

    authors: Mandal R,Singh M,Krishnan AAV,Dahat YH,Bharitkar YP,Ravichandiran V,Hazra A

    更新日期:2020-08-01 00:00:00

  • A new lanostane-type triterpene and sesquiterpene lactones from Vernonia leopoldii and their in vitro cytotoxicity.

    abstract::Investigation of the aerial parts of Vernonia leopoldii (Sch. Bip.) Vatke afforded a new lanostane-type triterpene along with known hirsutinolide-type sesquiterpene lactones and flavonoid glycosides, all are identified for the first time in this species. The new compound was identified as lanost-3β, 23S-dihydroxy-22(3...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2015.1062004

    authors: Marzouk AM,Abd Elhalim OB

    更新日期:2016-01-01 00:00:00