LC determination and pharmacokinetic study of the main phenolic components of Portulaca oleracea L. extract in rat plasma after oral administration.

Abstract:

:This study investigated the pharmacokinetics of hesperidin (HP), ferulic acid (FA) and p-coumaric acid (CA) in rat plasma after oral administration of Portulaca oleracea L. extract (POE). The plasma concentrations were determined by HPLC with vitexin-2″-O-rhamnoside (VR) as internal standard. The calibration curves were linear over the range 0.1-5 µg mL(-1), 0.1-5 µg mL(-1)and 0.015-3 µg mL(-1) for HP, FA and CA, respectively. The validated method was suitable to the pharmacokinetic study of HP, FA and CA in rats after oral administration at a single dose of POE.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Cheng Z,Wang D,Zhang W,Du Y,Wang Y,Zhai Y,Ying X,Kang T

doi

10.1080/14786419.2011.648193

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

2247-50

issue

23

eissn

1478-6419

issn

1478-6427

journal_volume

26

pub_type

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