Abstract:
:This study investigated the pharmacokinetics of hesperidin (HP), ferulic acid (FA) and p-coumaric acid (CA) in rat plasma after oral administration of Portulaca oleracea L. extract (POE). The plasma concentrations were determined by HPLC with vitexin-2″-O-rhamnoside (VR) as internal standard. The calibration curves were linear over the range 0.1-5 µg mL(-1), 0.1-5 µg mL(-1)and 0.015-3 µg mL(-1) for HP, FA and CA, respectively. The validated method was suitable to the pharmacokinetic study of HP, FA and CA in rats after oral administration at a single dose of POE.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Cheng Z,Wang D,Zhang W,Du Y,Wang Y,Zhai Y,Ying X,Kang Tdoi
10.1080/14786419.2011.648193subject
Has Abstractpub_date
2012-01-01 00:00:00pages
2247-50issue
23eissn
1478-6419issn
1478-6427journal_volume
26pub_type
杂志文章abstract::Two new flavonoids, 3, 3', 4' -Trihydroxy- 6, 7, 8 -trimethoxy flavone (1) and 3-Hydroxy-6, 7, 8, 3', 4'-pentamethoxy flavone (2) have been isolated from the methanol extract of Blumea eriantha DC. The structures of these compounds were determined on the basis of spectroscopic techniques such as IR, MS, 1 D, and 2 D N...
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