Bioactive metabolites of hass and reed avocados targeting methicillin-resistant Staphylococcus aureus enterotoxin-like X via molecular modeling and cytotoxicity assessments.

abstract：:One new furofuran lignan 2-methoxy-9β-hydroxydiasesamin (1), and four analogues (2-5), together with eight alkaloids (6-13), were isolated from the ethanol extract of the aerial part of Clinacanthus nutans. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. All the compounds...

journal_title：Natural product research

authors： Diao HZ,Chen WH,Cao J,Shao TM,Song XP,Han CR

更新日期：2019-05-01 00:00:00

abstract：:The search for bioactive compounds against diseases is imperative and the richness of the Amazon provides a large source to be explored. Current therapies for the treatment of parasitic infections have severe side effects and low efficacy, which makes the development of an effective chemotherapy extremely important. I...

journal_title：Natural product research

authors： Fernandes NS,Desoti VC,Dias A,da Silva YC,de Azevedo Dos Santos AP,Passarini GM,Nakamura CV,da Veiga Junior VF

更新日期：2020-01-25 00:00:00

abstract：:A wide range of proteinaceous inhibitors are present in plants to protect themselves from hydrolytic enzymes. In this study, turmerin, a water-soluble peptide in turmeric rhizomes, was evaluated for its inhibitory potential against glucosidase and its antioxidant (AO) capacity. Turmerin inhibited α-amylase and α-gluco...

journal_title：Natural product research

authors： Lekshmi PC,Arimboor R,Raghu KG,Menon AN

更新日期：2012-01-01 00:00:00

abstract：:The CDC25 phosphatases regulate the cell division cycle by controlling the activity of cyclin-dependent kinases. While screening for inhibitors of phosphatases among natural products we repeatedly found that some polyprenyl-hydroquinones and polyprenyl-furans (furanoterpenoids) (furospongins, furospinosulins) were pot...

journal_title：Natural product research

authors： Erdogan-Orhan I,Sener B,de Rosa S,Perez-Baz J,Lozach O,Leost M,Rakhilin S,Meijer L

更新日期：2004-02-01 00:00:00

abstract：:As part of continuing our research on diverse C-7 derivatives of camptothecin (CPT), 16 CPT derivatives bearing piperazinyl-thiourea chemical scaffold and different substituent groups have been designed, synthesized and evaluated in vitro for cytotoxicity against five tumor cell lines (A-549, MDA-MB-231, MCF-7, KB and...

journal_title：Natural product research

authors： Song ZL,Yang GZ,Li JC,Liu YQ,Yang CJ,Goto M,Zhang ZJ,Morris-Natschke SL,Liu H,Lee KH

更新日期：2020-07-01 00:00:00

abstract：:Sanguisorba officinalis L. is a traditional herbal plant that belongs to the genus Sanguisorba and the family Rosaceae. A new ursane-type triterpenoid, 3-oxo-urs-11, 13(18)-dien-19, 28-olide (1), two known ursane-type triterpenoids (3 - 4) and three known oleanane-type triterpenoids (2, 5 - 6) were isolated from the r...

journal_title：Natural product research

authors： Wang R,Sun J,Jin M,Jin L,Qi Y,Cao L,Zhou W,Li G

更新日期：2019-12-04 00:00:00

abstract：:This study was designed to investigate possible antidepressant-like effects of the extract prepared from the flowers of Hypericum montbretti Spach. (Guttiferae, Clusiaceae). Phytochemical constituents of the methanolic extract were analysed by HPLC method. The main flavonoid component was detected as rutin, and anothe...

journal_title：Natural product research

authors： Can OD,Ismail IB,Oztürk Y,Oztürk N,Potoğlu-Erkara I,Sagratini G,Ricciutelli M,Vittori S,Maggi F

更新日期：2011-09-01 00:00:00

abstract：:The oral squamous cell carcinoma (OSCC) is the eighth more common cancer in men. The development of new and more efficient drugs is needed. Plants of the genus Piper are popularly used in the treatment of many diseases. This study evaluated the antitumor effect of extract, fraction and isolated compounds from leaves o...

journal_title：Natural product research

authors： Fonseca ACCD,de Queiroz LN,Sales Felisberto J,Jessé Ramos Y,Mesquita Marques A,Wermelinger GF,Pontes B,de Lima Moreira D,Robbs BK

更新日期：2020-10-14 00:00:00

abstract：:Seven pentacyclic triterpenoids including 3beta-O-(E)-coumaroyl-15alpha-hydroxy-beta-amyrin (1), 15alpha-hydroxy-beta-amyrin (2), 3beta-taraxerol (3), 3beta-taraxerol formate (4), 3beta-taraxerol acetate (5), 3beta-O-(E)-coumaroyl-taraxerol (6), and 3beta-O-(Z)-coumaroyl-taraxerol (7) were isolated and identified from...

journal_title：Natural product research

authors： Li DL,Li XM,Wang BG

更新日期：2008-06-15 00:00:00

abstract：:The Perovskia artemisioides Boiss. essential oil obtained by hydrodistillation method of flowers growing wild in the north of Iran. The study led to the identification of 29 compositions by a combination of HP-5 GC-FID and GC-MS analytical techniques. The constituents were identified in P. artemisioides essential oil ...

journal_title：Natural product research

authors： Hafez Ghoran S,Azadi B,Hussain H

更新日期：2016-09-01 00:00:00

abstract：:Continued investigation of the marine alga Laurencia claviformis has led to the isolation of pacifenol, a halogenated sesquiterpene as the major metabolite. The microbial transformation of pacifenol is reported. It was cultivated with a marine strain of Penicillium brevicompactum yielding a new compound. The structure...

journal_title：Natural product research

authors： San-Martín A,Rovirosa J,Astudillo L,Sepúlveda B,Ruiz D,San-Martín C

更新日期：2008-12-01 00:00:00

abstract：:Colletia paradoxa (Spreng.) Esc. (Rhamnaceae, Colletieae) is a medicinal plant, threatened with extinction in Brazil, presenting great morphological variability. Our objective is to investigate the phytochemical components, antioxidant capacity and antimycobacterial activity of different morphotypes of C. paradoxa in ...

journal_title：Natural product research

authors： Bastos Záchia NR,Piana M,Dos Santos Siqueira F,da Silva Jesus R,Athayde ML,Essi L,de Campos MMA

更新日期：2019-04-16 00:00:00

abstract：:In this study, the effects of Benzoinum and Styrax on Escherichia coli (E. coli) growth were investigated by microcalorimetry. Using a TAM Air Isothermal Calorimeter, ampoule method, the power-time curves of E. coli growth at 37°C affected by Benzoinum and Styrax were measured. By analysing some quantitative thermokin...

journal_title：Natural product research

authors： Wang J,Cheng D,Zeng N,Xia H,Fu Y,Yan D,Zhao Y,Xiao X

更新日期：2011-02-01 00:00:00

abstract：:This study discusses the similarities and differences between the antioxidant activities of some essential oils: thyme (Thymus vulgaris), basil (Ocimum basilicum), peppermint (Mentha piperita), clove (Caryophyllus aromaticus), summer savory (Satureja hortensis), sage (Salvia hispanica) and lemon (Citrus limon (L.) Bur...

journal_title：Natural product research

authors： Dawidowicz AL,Olszowy M

更新日期：2014-01-01 00:00:00

abstract：:A new sesquiterpenoid, malayscaphiol (1), and three known compounds, lupeol (2), lupenone (3) and stigmasterol (4), were isolated from the methanolic extract of the stem bark of Scaphium macropodum. The structures of the isolated compounds were determined using several spectroscopic methods, including UV-vis, FT-IR, 1...

journal_title：Natural product research

authors： Al Muqarrabun LM,Ahmat N,Aris SR,Shamsulrijal N,Baharum SN,Ahmad R,Rosandy AR,Suratman MN,Takayama H

更新日期：2014-01-01 00:00:00

abstract：:Bothrops jararacussu venom's (Bj2015) batch was biomonitored quarterly for one year to assess phospholipase A2 (PLA2) activity, immunogenicity, neurotoxicity, and myotoxicity. In silico models were applied to evaluate losses using decay model and recoveries by predictive trend analysis. Mice were immunized with Bj2015...

journal_title：Natural product research

authors： Oliveira ICF,Mora AD,Neto JB,de Oliveira ÁL,Harder C,Hanai-Yoshida VM,Cogo JC,Floriano RS,Bonventi Junior W,Oliveira SJ,Oshima-Franco Y

更新日期：2019-08-01 00:00:00

abstract：:Investigation of the aerial parts of Vernonia leopoldii (Sch. Bip.) Vatke afforded a new lanostane-type triterpene along with known hirsutinolide-type sesquiterpene lactones and flavonoid glycosides, all are identified for the first time in this species. The new compound was identified as lanost-3β, 23S-dihydroxy-22(3...

journal_title：Natural product research

authors： Marzouk AM,Abd Elhalim OB

更新日期：2016-01-01 00:00:00

abstract：:A new androstanoid metabolite, 4α-methyl-9α-methoxyandrosta-8,15-diene-3,17-dione (1), was isolated from a soil fungus Curvularia borreriae (Pleosporaceae) strain HS-FG-237. Its structure was determined by extensive spectroscopic and X-ray diffraction analyses. Compound 1 exhibited poor cytotoxicity toward HCT-116 cel...

journal_title：Natural product research

authors： Liu LF,Zhang H,Qi H,Wang XM,Wang JD,Tan GS

更新日期：2017-05-01 00:00:00

abstract：:Penicillium polonicum MCCC3A00951 is a fungus with influenza neuraminidase (NA) inhibition activity derived from a sediment of the mangrove forest of Zhangjiangkou in Fujian province, China. Chemical investigation on an ethyl acetate extract of its fermentation led to the isolation of a new compound, 7-hydroxy-3,10-de...

journal_title：Natural product research

authors： Liu SZ,He FM,Bin YL,Li CF,Xie BY,Tang XX,Qiu YK

更新日期：2020-09-14 00:00:00

abstract：:A new phenolic glycoside, methylpicraquassioside B (6), together with nine known glycosides, cnidioside A (1), cnidioside B (2), picraquassioside A (3), methylpicraquassioside A (4), picraquassioside B (5), xanthotoxol-8-β-glucoside (7), 5-methoxy-xanthotoxol-8-β-glucoside (8), 8-methoxy-xanthotoxol-5-β-glucoside (9) ...

journal_title：Natural product research

authors： Kim SB,Chang BY,Han SB,Hwang BY,Kim SY,Lee MK

更新日期：2013-01-01 00:00:00

abstract：:The aim of this study was to investigate the influence of both facility location and typology of fish farm on some ecotoxicological, qualitative and reproductive variables in European sea bass Dicentrarchus labrax L. Several variables were investigated: gonado-somatic index (GSI), liver-somatic index (LSI); 7-ethoxyre...

journal_title：Natural product research

authors： Cangialosi MV,Corsi I,Bonacci S,Sensini C,Cicero N,Focardi S,Mazzola A

更新日期：2013-04-01 00:00:00

abstract：:Three new phenanthrenone constituents, trigoxyphins U-W (1, 7 and 9), together with eight known ones, trigoxyphin M (2), 6,9-O-dimethyltrigonostemone (3), trigonstemone (4), thrigonosomone B (5), trigonochinene E (6), actephiiol A (8), epiactephilol A (10) and neoboutomannin (11), were obtained from the methanol extra...

journal_title：Natural product research

authors： Li SF,He HP,Hao XJ

更新日期：2015-01-01 00:00:00

abstract：:A novel alkaloid named oleraciamide C (1), with six known compounds, hydroxydihydrobovolide (2), uracil (3), catechol (4), 4-aminophenol (5), vanillic acid (6) as well as 3-hydroxypyridine (7), were isolated from Portulaca oleracea L. Additionally, hydroxydihydrobovolide (2), 4-aminophenol (5), 3-hydroxypyridine (7) w...

journal_title：Natural product research

authors： Xu L,Ying Z,Wei W,Hao D,Wang H,Zhang W,Li C,Jiang M,Ying X,Liu J

更新日期：2017-04-01 00:00:00

abstract：:One new triterpenoid olean-18-ene-1β, 2α, 3β-triol (1) along with four known compounds were isolated from the chloroform extract of the aerial part of Salvia atropatana Bunge. The known compounds were two flavonoids, 5-hydroxy-7,4'-dimethoxyflavone (2) and 5-hydroxy-6,7,4'-trimethoxyflavone (3), an abietane-type diter...

journal_title：Natural product research

authors： Habibi Z,Cheraghi Z,Ghasemi S,Yousefi M

更新日期：2012-01-01 00:00:00

abstract：:Four fractions were prepared from the crude extract of Caesalpinia minax Hance and the inhibitory activity of nitric oxide (NO) production release of RAW 264.7 cells stimulated by lipopolysaccharide (LPS) was evaluated. The ethyl acetate (EtOAc) fraction showed obvious inhibitory effect. Bioassay-guided fractionation ...

journal_title：Natural product research

authors： Liu Q,Bai B,Yang DP,Peng SY,Zhu LP,Luo MH,Zhao ZM

更新日期：2018-04-01 00:00:00

abstract：:Two new flavonoids, 8-hydroxyisoscoparin (1) and luteolin 7-O-glucoside 4''-sulfate (2), along with eight known flavonoids, including luteolin 7-O-glucoside 2''-sulfate, were isolated and identified from Washingtonia filifera. All compounds were characterized by (1)H-NMR, (13)C-NMR, CI-MS, FABMS and UV. The antioxidan...

journal_title：Natural product research

authors： El-Sayed NH,Ammar NM,Al-Okbi SY,El-Kassem LT,Mabry TJ

更新日期：2006-01-01 00:00:00

abstract：:Moringa oleifera Lam. family Moringaceae is well known for a wide range of biological activities and a complex phytochemical composition. The current study investigates tissue culture protocols for Moringa oleifera leaves and seeds. For static culture initiation, Murashige and skooge (MS) as a basal medium with hormon...

journal_title：Natural product research

authors： Mustafa R,El-Naggar EMB,Svajdlenka E,Omran G,ELFiky F,El-Hawiet A

更新日期：2020-03-25 00:00:00

abstract：:Spinacia oleracea L. (Spinach) is a leafy vegetable which is considered to have a high nutritional value. Flavonoids in spinach were reported to act as antimutagenic property. Rapid detection of these flavonoids in Spinach was achieved by using HPLC-ESI-QTOF-MS/MS. Thirty six compounds were tentatively identified base...

journal_title：Natural product research

authors： Singh A,Singh P,Kumar B,Kumar S,Dev K,Maurya R

更新日期：2019-08-01 00:00:00

abstract：:Meliquercifolins A (1), and B (2), two new coumarins are bearing an acetophenone derivative were isolated from the leaves of Melicope quercifolia along with three known compounds, melicodenines E (3), F (4) and I (5). Structures of two new compounds were identified based on spectroscopic analyses (UV, HR-ESI-MS, 1 D a...

journal_title：Natural product research

authors： Saputri RD,Tjahjandarie TS,Tanjung M

更新日期：2019-07-22 00:00:00

abstract：:Two new eremophilanolides, sibiriolides A (1) and B (2), were isolated from the aerial parts of Xanthium sibiricum. The structures of the new compounds were identified as 4S,5R,7R,8R, 11R-2-oxo-1(10)-eremophilen-12,8-olide (1) and 4S,5R,7R,8R,11S-2-oxo-1(10)-eremophilen-12,8-olide (2) by HREIMS and NMR spectroscopic t...

journal_title：Natural product research

authors： Zhang XQ,Ye WC,Jiang RW,Yin ZQ,Zhao SX,Mak TC,Yao XS

更新日期：2006-11-01 00:00:00