Two novel coumarins bearing an acetophenone derivative from the leaves of Melicope Quercifolia.

Abstract:

:Meliquercifolins A (1), and B (2), two new coumarins are bearing an acetophenone derivative were isolated from the leaves of Melicope quercifolia along with three known compounds, melicodenines E (3), F (4) and I (5). Structures of two new compounds were identified based on spectroscopic analyses (UV, HR-ESI-MS, 1 D and 2 D NMR). Cytotoxic activities of compounds (1-5) towards three human cancer cells (HeLa, MCF-7, P-388), compounds 1, 4 and 5 showed very potent activity against Hela cells with IC50 values 2.6; 0.8; 1.1 μM, respectively.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Saputri RD,Tjahjandarie TS,Tanjung M

doi

10.1080/14786419.2019.1644634

subject

Has Abstract

pub_date

2019-07-22 00:00:00

pages

1-6

eissn

1478-6419

issn

1478-6427

pub_type

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