Design and synthesis of novel 7-[(N-substituted-thioureidopiperazinyl)-methyl]-camptothecin derivatives as potential cytotoxic agents.

abstract：:The chemical composition of the methanol extract obtained from Araucaria cunninghamii Sweet. bark was determined by GC-MS analysis with its antioxidant and antibacterial potential, for the first time. A total of 73 compounds were identified and the extract was strongly characterised by Viridiflorene; Androstan-17-one,...

journal_title：Natural product research

authors： Kumar P,Sati SC,Khulbe K,Pant P,Tripathi AN,Sarvendra K

更新日期：2020-11-29 00:00:00

abstract：:A new oleanolic-type triterpene glycoside, (3β,21β)-21-[(β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl)oxy]-3-hydroxyolean-12-en-28-oic acid (1), together with five analogues, oleanazuroside 1 (2), oleanazuroside 2 (3), 24-hydroxytormentic acid ester glucoside (4), 24-epi-pinfaensin (5), and oleanolic acid 3-O-α-l-arabi...

journal_title：Natural product research

authors： Chen KK,Xie ZJ,Dai W,Wang Q

更新日期：2017-04-01 00:00:00

abstract：:Phytochemical reinvestigation on the whole plants of Derris laxiflora Benth. afforded two new diprenylated flavanones, derriflavanones B and C (1-2), together with thirty-two known compounds, including sixteen flavonoids (3-18), eleven aromatic compounds (19-29), and five chlorophylls (30-34). All known compounds were...

journal_title：Natural product research

authors： Huang HC,Chien SC,Kuo CC,Wu MD,Cheng MJ,Chen JJ,Chiu HL,Kuo YH

更新日期：2020-08-01 00:00:00

abstract：:A new xanthone named cratoxylumxanthone A (1), together with five known compounds: dulcisxanthone B (2), alpha-mangostin (3), beta-mangostin (4), 2-geranyl-1,3,7-trihydroxy-4-(3-methylbut-2-enyl)xanthone (5) and tectochrystin (6), was isolated from Cratoxylum cochinchinense stems. The structure of new compound was cha...

journal_title：Natural product research

authors： Phuwapraisirisan P,Udomchotphruet S,Surapinit S,Tip-Pyang S

更新日期：2006-12-01 00:00:00

abstract：:Diphysidione (1), a new p-hydroxyphenyl anhydride, and vitexin (2) were isolated from the leaves of Diphysa carthagenensis. The structure of the new metabolite was characterised as 4-(4-hydroxy-phenyl)-3H-pyran-2,6-dione using 1D and 2D NMR spectroscopy. ...

journal_title：Natural product research

authors： Torres-Tapia LW,Sosa-Espinosa T,Peraza-Sánchez SR

更新日期：2013-01-01 00:00:00

abstract：:The study examined the radioprotective activity of an aqueous extract from Pleurotus ostreatus mycelium administered to Balb/c mice. Male mice were whole-body irradiated on day 0 ((60)Co, at 0.43 Gy/min) and divided into two groups. The extract was administered intraperitoneally to one group (100 mg/kg) on days - 10 t...

journal_title：Natural product research

authors： Llauradó G,Morris HJ,Tamayo V,Lebeque Y,Beltrán Y,Marcos J,Moukha S,Creppy EE,Bermúdez RC

更新日期：2015-01-01 00:00:00

abstract：:Two new cycloartane-type glycosides, caspicuside I and caspicuside II, were isolated along with two known saponins, cycloastragenol and astragaloside IV, from the roots of Astragalus caspicus. As the aglycon group, caspicuside I possesses 3beta,6alpha,16beta,(24S),25-pentahydroxycycloartane (cyclocanthagenol), while c...

journal_title：Natural product research

authors： Fathiazad F,Khosropanah MK,Movafeghi A

更新日期：2010-07-01 00:00:00

abstract：:The use of a matrix solid-phase dispersion (MSPD) process to extract polyphenols from hawthorn (Crataegus oxyacantha L.) a deciduous shrub with an expected rich phytochemical profile, has been evaluated. MSPD extracts of fruits and leaves have an outstanding content of polyphenols, although the particular phenolic pro...

journal_title：Natural product research

authors： Benabderrahmane W,Lores M,Lamas JP,Benayache S

更新日期：2018-05-01 00:00:00

abstract：:This study evaluated the roles of zeatin (2 mg/L) on direct organogenesis, phytochemical compounds, antioxidant activity, and cytotoxic activity in regenerated shoots of red cabbage. The results revealed that the extract of explant treated by 2 mg/L zeatin gives the highest content of total phenolics (5.18 mg gallic a...

journal_title：Natural product research

authors： Ravanfar SA,Karimi E,Mehrabanjoubani P,Ebrahimi M

更新日期：2020-03-01 00:00:00

abstract：:One new anthraquinone, 1,8-dihydroxy-2-ethyl-3-methylanthraquinone (1), together with two known compounds octadecanoic acid (2) and cholest-4-en-3-one (3) was isolated from marine actinomycete Streptomyces sp. FX-58. The structure of 1 was elucidated on the basis of spectroscopic methods, especially, the 2D-NMR spectr...

journal_title：Natural product research

authors： Huang YF,Tian L,Fu HW,Hua HM,Pei YH

更新日期：2006-11-01 00:00:00

abstract：:Three new flavonol glycosides (1-3), hippophins K-M, were isolated from the seed residue of Hippophae rhamnoides subsp. sinensis. The chemical structures of these three new compounds were identified by 1D, 2D NMR, mass spectroscopy and high resolution electrospray ionization mass spectrometry spectroscopic data and by...

journal_title：Natural product research

authors： Chen C,Gao W,Ou-Yang DW,Zhang J,Kong DY

更新日期：2014-01-01 00:00:00

abstract：:Fructose feeding induces a rise in blood pressure in normal rats that is associated with insulin resistance, hyperinsulinemia, hyperglycaemia, hypercholesterolaemia and hypertriglyceridaemia. We have examined the effect of chronic administration of A-HRS (100 and 300 mg kg⁻¹; p.o.) isolated from Hibiscus rosa sinensis...

journal_title：Natural product research

authors： Mohan M,Khade B,Shinde A

更新日期：2012-01-01 00:00:00

abstract：:A new furan derivative named 3-(5-oxo-2,5-dihydrofuran-3-yl) propanoic acid (1) was isolated for the first time. Its structure was elucidated by UV, IR, NMR, HR-ESI-MS and the single-crystal X-ray diffraction spectroscopic data. Meanwhile, the antifungal and antibacterial activities of compound 1 was tested, it exhibi...

journal_title：Natural product research

authors： Yang XF,Wang NN,Kang YF,Ma YM

更新日期：2019-10-01 00:00:00

abstract：:Sanguisorba officinalis L. is a traditional herbal plant that belongs to the genus Sanguisorba and the family Rosaceae. A new ursane-type triterpenoid, 3-oxo-urs-11, 13(18)-dien-19, 28-olide (1), two known ursane-type triterpenoids (3 - 4) and three known oleanane-type triterpenoids (2, 5 - 6) were isolated from the r...

journal_title：Natural product research

authors： Wang R,Sun J,Jin M,Jin L,Qi Y,Cao L,Zhou W,Li G

更新日期：2019-12-04 00:00:00

abstract：:Peperomia obtusifolia is a herbaceous perennial plant native to the Americas reported as a traditional medicine to treat snake bites and as a skin cleanser. The bioassay-guided fractionation of crude extracts from aerial parts of P. obtusifolia against a panel of clinically important fungi and bacteria, showed that he...

journal_title：Natural product research

authors： Ruiz Mostacero N,Castelli MV,Cutró AC,Hollmann A,Batista JM Jr,Furlan M,Valles J,Fulgueira CL,López SN

更新日期：2019-06-14 00:00:00

abstract：:A new 1,4-napthoquinone derivative, namely (S)-(-)-3-(8-hydroxy-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-3-(4-hydroxy-3-methoxyphenyl)-propionic acid methyl ester (1), was isolated from the roots of Juglans mandshurica Maxim. The structure was identified based on HR-ESI-MS, 1D and 2D NMR spectroscopic methods. ...

journal_title：Natural product research

authors： Jiang Z,Diao S,Li R,Zhou W,Sun J,Zhou Y,Jin Y,Jin M,Li G

更新日期：2018-05-01 00:00:00

abstract：:The search for bioactive compounds against diseases is imperative and the richness of the Amazon provides a large source to be explored. Current therapies for the treatment of parasitic infections have severe side effects and low efficacy, which makes the development of an effective chemotherapy extremely important. I...

journal_title：Natural product research

authors： Fernandes NS,Desoti VC,Dias A,da Silva YC,de Azevedo Dos Santos AP,Passarini GM,Nakamura CV,da Veiga Junior VF

更新日期：2020-01-25 00:00:00

abstract：:In the present study, evaluation of the antiproliferative activity of Pachypodium lamerei Drake leaves (family Apocyaceae) against human breast cancer cell lines MDA-MB-231 was done for the total methanolic extract, crude alkaloidal mixture and ursolic acid using the MTT colorimetric assay. The methanolic extract show...

journal_title：Natural product research

authors： Mina SA,Mohamed SA,Melek FR,Abd El-Khalik SM

更新日期：2020-05-01 00:00:00

abstract：:Essential oils from aerial parts of Senecio nutans, Senecio viridis, Tagetes terniflora and Aloysia gratissima were analysed by GC-MS and their antifungal activities were assayed on toxigenic Fusarium and Aspergillus species. Sabinene (27.6 ± 0.1%), α-phellandrene (15.7 ± 0.3%), o-cymene (9.6 ± 0.2%) and β-pinene (6.1...

journal_title：Natural product research

authors： Galvez CE,Jimenez CM,Gomez ALA,Lizarraga EF,Sampietro DA

更新日期：2020-05-01 00:00:00

abstract：:Study of the chemical constituents of ethanol extract from the aerial parts of Atalantia buxifolia led to the identification of a new acridone alkaloid named as buxifoliadine (1), along with known compounds citrusinine--I (2), N-methylatalaphylline (3), Severinolid (4) and cycloseverinolide (5). Structural elucidation...

journal_title：Natural product research

authors： Shan F,Yin YQ,Huang F,Huang YC,Guo LB,Wu YF

更新日期：2013-01-01 00:00:00

abstract：:A simple extraction procedure and HPLC method was developed to analyse the major and minor components of induced phytoalexins of elicited tissues (seeds) of chickpeas (Cicer arietinum L.) and peas (Pisum sativum L.) treated with a biotic elicitor (k-carrageenan) of Hypnea musciformis (red algae) from the Karachi coast...

journal_title：Natural product research

authors： Arman M

更新日期：2011-08-01 00:00:00

abstract：:The objective of this study was to determine whether endophytic fungi, isolated from Kadsura angustifolia produce nigranoic acid and its highly oxygenated derivatives. From the 426 endophytic fungi screened, Trichoderma harzianum SWUKD3.1610 was detected to have a component with the same TLC R ...

journal_title：Natural product research

authors： Han M,Qin D,Ye T,Yan X,Wang J,Duan X,Dong J

更新日期：2019-07-01 00:00:00

abstract：:Flavonoids have always attracted much attention due to their reversal activity on multidrug resistance (MDR). Eight flavonoids isolated from traditional Chinese medicine Sophora alopecuroides L. were applied to test their effect on MDR associated protein 1 (MRP1) through the established predicting assay. Three flavono...

journal_title：Natural product research

authors： Ni K,Yang L,Wan C,Xia Y,Kong L

更新日期：2014-01-01 00:00:00

abstract：:The hexane fraction from the roots of Echinops ellenbeckii O. Hoffm. from Ethiopia yielded seven acetylenic thiophenes of which five compounds (1, 3, 4, 6, 7) are reported for the first time in this species: the monothiophenes 5-(penta-1,3-diynyl)-2-(but-3-en-1-ynyl)-thiophene (1), 5-(penta-1,3-diynyl)-2-(4-acetoxy-bu...

journal_title：Natural product research

authors： Hymete A,Rohloff J,Kjøsen H,Iversen TH

更新日期：2005-12-01 00:00:00

abstract：:A new phenolic glycoside, 6-O-(4'-hydroxy-3',5'-dimethoxybenzoyl)-d-glucopyranose (4), and nine known compounds (1-3 and 5-10) were isolated from Juglans mandshurica Maxim. Compound structures were elucidated by NMR, HR-ESI-MS and acid hydrolysis. Compounds 5 and 6 are reported from this genus for the first time. Amon...

journal_title：Natural product research

authors： Yao D,Jin M,Zhang C,Luo J,Li R,Zheng M,Cui J,Li G

更新日期：2014-01-01 00:00:00

abstract：:A sesquiterpenoid quinone, epi-ilimaquinone (1), and two sesquiterpene amino quinones, smenospongine (2) and glycinylilimaquinone (3), were isolated from the Fijian marine sponge Hippospongia sp. The structures of these compounds were determined by spectroscopic analysis. Compounds 1 and 3 were reported for the first ...

journal_title：Natural product research

authors： Kumar R,Subramani R,Aalbersberg W

更新日期：2013-01-01 00:00:00

abstract：:This article investigates the effect of microwaves on the amount of volatile compounds Achillea tenuifolia Lam with two methods, headspace single-drop microextraction and microwave-assisted headspace single-drop microextraction (MA-SDME), for the analysis of essential oil. Solvent selection, solvent volume, microwave ...

journal_title：Natural product research

authors： Piryaei M,Nazemiyeh H

更新日期：2016-01-01 00:00:00

abstract：:Several Mediterranean shrubs, both autochthonous and naturalized, have been traditionally used as food, flavouring and/or spicing agents, and as phytopharmaceuticals. The interest around 'natural' and 'biological' products is steadily increasing in developed countries. Therefore, it seems reasonable to screen some shr...

journal_title：Natural product research

authors： Sanjust E,Mocci G,Zucca P,Rescigno A

更新日期：2008-05-20 00:00:00

abstract：:Two alkaloids of the furoquinoline-type were isolated from Ammi majus L.; a new one and was identified as 4-hydro-7-hydroxy-8-methoxyfuroquinoline (1), and the other was isolated for the second time from nature and was identified as 4-hydro-7-hydroxy-8-prenyloxyfuroquinoline (2). The structures of the isolated compoun...

journal_title：Natural product research

authors： Mohammed MM,El-Sharkawy ER

更新日期：2017-03-01 00:00:00

abstract：:A phytochemical study of Asplenium ruta-muraria L. (Aspleniaceae) led to the isolation of a new caffeic acid glycoside, 2-O-caffeoyl-β-D-fructofuranosyl-(2 → 1)-α-D-glucopyranoside and an (α, β)-isomeric pair of 2E-caffeoyl-D-glucopyranoside, together with kaempferol-3-O-β-D-[6-E-caffeoyl-β-D-glucopyranosyl-(1 → 2)glu...

journal_title：Natural product research

authors： Fan P,Zhao L,Hostettmann K,Lou H

更新日期：2012-01-01 00:00:00