Abstract:
:The study examined the radioprotective activity of an aqueous extract from Pleurotus ostreatus mycelium administered to Balb/c mice. Male mice were whole-body irradiated on day 0 ((60)Co, at 0.43 Gy/min) and divided into two groups. The extract was administered intraperitoneally to one group (100 mg/kg) on days - 10 to - 6 and - 2 to +1 with respect to the irradiation. The irradiated-control group was injected with saline solution; non-irradiated mice were used as negative controls. The radioprotective effect was evident by increases in bone marrow cellularity (5.1 × 10(6)/femur vs. 1.1 × 10(6)/femur in saline-control mice, p < 0.05), leucocyte counts (10.5 × 10(9)/L vs. 4.5 × 10(9)/L, p < 0.05), and spleen cellularity (11.2 × 10(7)/spleen vs. 6.2 × 10(7)/spleen, p < 0.05). The extract stimulated macrophage phagocytic activity as judged by a faster rate of carbon clearance in terms of absorbance ratios (1.62 vs. 2.01, p < 0.05). Therefore, this extract may be a candidate therapeutic agent with radioprotective activity for haematopoiesis damage, particularly to cells involved in immune function.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Llauradó G,Morris HJ,Tamayo V,Lebeque Y,Beltrán Y,Marcos J,Moukha S,Creppy EE,Bermúdez RCdoi
10.1080/14786419.2014.983918subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1557-61issue
16eissn
1478-6419issn
1478-6427journal_volume
29pub_type
杂志文章abstract::Antibacterial activities of prenylated xanthones from Garcinia mangostana and their synthetic analogues were investigated, and their structure-activity relationships have been studied. γ-Mangostin has shown antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphyl...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.678348
更新日期:2013-01-01 00:00:00
abstract::Novel derivatives of 4-oxo-3-methylcytisine with phenyl moiety bonded to starting molecule through various spacers were obtained from the 9-amino, -halo, -formyl and 11-halo precursors by reductive alkylation of amines, generation of amide, as well as thio- and carboxamide functions, cross-coupling reactions, aldehyde...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1622106
更新日期:2021-01-01 00:00:00
abstract::The anti-enteroviral activity of three stilbenoids isolated from the leaves of Macaranga barteri was investigated using the cytopathic effect reduction assay. The stilbenes were inactive against echovirus E13 but showed activity against echoviruses E7 and E19. In particular, vedelianin (2), schweinfurthin G (3) and ma...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1644505
更新日期:2019-07-25 00:00:00
abstract::Chronic administration of myricetin (100 and 300 mg kg⁻¹, p.o., for 4 weeks) isolated from Vitis vinifera (Vitaceae) ameliorated hypertension and oxidative stress induced by deoxycorticosterone acetate (DOCA)-salt in rats. Myricetin treatment reduced systolic blood pressure, vascular reactivity changes and reversed th...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410903335190
更新日期:2011-09-01 00:00:00
abstract::Methanolic extracts of 18 Thai plants from Doi Tung, the north of Thailand, were examined for brine shrimp lethality and antioxidative activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. In brine shrimp lethality, the highly toxic plant extracts were Mitrephora wangii (LC(50) 14.8 µg mL(-1)) and Hydrocotyle jav...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.534469
更新日期:2012-01-01 00:00:00
abstract::Among phenolic compounds, Agave americana L. extract contained puerarin (38.4%) and p-coumaric acid (12.29%) (pCa). From the Lineweaver-Burk plots, pCa and puerarin demonstrated a competitive and a non competitive inhibitions towards human α-amylase activity, respectively. PCa exhibited a higher human inhibitory activ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1408094
更新日期:2019-03-01 00:00:00
abstract::A new 1,4-napthoquinone derivative, namely (S)-(-)-3-(8-hydroxy-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-3-(4-hydroxy-3-methoxyphenyl)-propionic acid methyl ester (1), was isolated from the roots of Juglans mandshurica Maxim. The structure was identified based on HR-ESI-MS, 1D and 2D NMR spectroscopic methods. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1375921
更新日期:2018-05-01 00:00:00
abstract::Loliolide content was determined in 13 marine algae including red, brown and green algae collected from the Black Sea, the Dardanelles and the Aegean Sea. Identification and quantification were performed by gas chromatography-mass spectrometry. The loliolide content in green alga is 1.76 microg g(-1), ranges from 0.14...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410802076069
更新日期:2009-01-01 00:00:00
abstract::In the present study, profiles of fatty acid, sn-2 fatty acid, triglyceride, phytochemical (including tocopherol/tocotrienol, phytosterol, flavonoid, carotenoid and polyphenol) and antioxidant capacity of extracts from the whole berry, pulp and seed of Hippophae¨ rhamnoides ssp. yunnanensis were investigated and compa...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1488703
更新日期:2019-12-01 00:00:00
abstract::A simple extraction procedure and HPLC method was developed to analyse the major and minor components of induced phytoalexins of elicited tissues (seeds) of chickpeas (Cicer arietinum L.) and peas (Pisum sativum L.) treated with a biotic elicitor (k-carrageenan) of Hypnea musciformis (red algae) from the Karachi coast...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.553952
更新日期:2011-08-01 00:00:00
abstract::Natural products represent a rich source of bioactive compounds that have been historically used to obtain substances with great medicinal potential. The skin of anuran amphibians is a rich source of compounds with a wide range of biological activity. Alzheimer's disease (AD) is a complex disease associated with all k...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1591396
更新日期:2019-03-31 00:00:00
abstract::From a biologically active fraction of extract from the fungus Fomitopsis pinicola, a new lanostane triterpene was isolated, 3alpha-acetyloxylanosta-8,24-diene-21-ol (1), along with two known triterpenic acids, (2) and (3). The structures of the compounds were elucidated based on their spectral properties. [structure:...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410500520251
更新日期:2007-05-01 00:00:00
abstract::Extracts obtained from Cyrtocarpa procera Kunth were evaluated to determine their toxicity on Artemia salina Leach. All the extracts showed a significant activity. Bioguided fractionation of these extracts led to the isolation of beta-sitosterol and the identification of 1,3-propyl-dipentadecanoate, 3-hydroxypropyl-9-...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410500045358
更新日期:2006-01-01 00:00:00
abstract::A novel alkaloid named oleraciamide C (1), with six known compounds, hydroxydihydrobovolide (2), uracil (3), catechol (4), 4-aminophenol (5), vanillic acid (6) as well as 3-hydroxypyridine (7), were isolated from Portulaca oleracea L. Additionally, hydroxydihydrobovolide (2), 4-aminophenol (5), 3-hydroxypyridine (7) w...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1253081
更新日期:2017-04-01 00:00:00
abstract::Phytochemical investigation of the twigs of Garcinia nobilis led to the isolation of a new xanthone, named l-hydroxy-2,5-dimethoxyxanthone (1), together with 15 known compounds (2-16). The structures of the new and known compounds were established by means of spectroscopic methods and by comparison with previously rep...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.903398
更新日期:2014-01-01 00:00:00
abstract::An actinomycete strain 200-09, isolated from a soil sample collected from the coast of Hawaii, USA, was identified as Streptomyces antibioticus on the basis of its morphological, physiological and biochemical characteristics as well as 16S rDNA analysis. A new antimycin-type antibiotic, kitamycin C (1), together with ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1295240
更新日期:2017-08-01 00:00:00
abstract::This paper addresses the application of infrared spectroscopy in combination with chemometrics to identify wall painting's binding medium while employing pattern recognition techniques to process FTIR data-set of complex samples. In this regard, based on the historical documents and previous researches, firstly 56 sta...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1108974
更新日期:2019-04-01 00:00:00
abstract::The antimicrobial activities of plant extracts have formed the basis of many alternative medicines. In this context, the genus Schinus L. (Anacardiaceae), exhibits many traditional uses in medicine. However, a few studies on the antimicrobial properties of Schinus areira essential oils were conducted. The essential oi...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1675065
更新日期:2019-10-12 00:00:00
abstract::This study reports for the first time in the chemical composition of acetone, ether, ethyl acetate and dichloromethane extracts of Hypogymnia tubulosa determined by HPLC-UV, GC-FID and GC-MS as well as effect of H. tubulosa acetone extract on micronucleus distribution on human lymphocytes and on cholinesterase activit...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1375926
更新日期:2018-11-01 00:00:00
abstract::A new eremophilane sesquiterpene, capnodiumone (1), along with five known eremophilane sesquiterpenes (2-6) and eight other compounds (7-14), have been isolated from a mangrove-associated fungus Capnodium sp. SZ-F22. The chemical structures were elucidated on the basis of extensive spectroscopic analysis. The broth ex...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1116000
更新日期:2016-07-01 00:00:00
abstract::The aim of study was to compare the content of phenolic acids and flavonoids in two cultivars of Lavandula angustifolia: 'Blue River' and 'Ellagance Purple', including flowers and leafy stalks. Total phenolics and total flavonoids contents were determined by UV-Vis spectroscopy. The contents of total phenolics in leaf...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1320792
更新日期:2017-11-01 00:00:00
abstract::Our laboratories have been investigating biological effects of a sesquiterpenoid polygodial and its natural and synthetic analogues. Herein, we report the evaluation of these compounds against the three forms of Trypanosoma cruzi, amastigotes, trypomastigotes and epimastigotes. Although polygodial was found to be poor...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1597350
更新日期:2019-04-28 00:00:00
abstract::Twenty-one phenolic compounds (1-21) including dihydrocinnamic acid, isoflavonoids, flavonoids, coumestans, pterocarpans, chalcones, isoflavan and isoflaven, were isolated from the roots of Glycyrrhiza pallidiflora Maxim. Phloretinic acid (1), chrysin (6), 9-methoxycoumestan (8), isoglycyrol (9), 6″-O-acetylanonin (19...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1188094
更新日期:2017-02-01 00:00:00
abstract::Two new benzoic acid derivatives, named methyl(S)-3-hydroxy-4-(2- hydroxy -6-methylheptan-2-yl)benzoate (1) and 2-hydroxy-3-(6- hydroxy-6-methylhept-1-en-2-yl)benzoic acid (2), were isolated from the ethanol extract of an endophytic fungus Aspergillus versicolor derived from the medicinal plant Euphorbia royleana. The...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1777121
更新日期:2020-06-11 00:00:00
abstract::The aim of this work was to provide a characterisation of volatile constituents from different commercial batches of henna (Lawsonia inermis) leaves of different geographic origin. Headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS) was used for the purpose. A tota...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1055491
更新日期:2016-01-01 00:00:00
abstract::Two new C13-norsesquiterpenes claulanterpene A (1) and B (2), together with two known sesquiterpenes (3-4), were isolated from methanol extract of the stem and leaf of Clausena lansium collected from Qingyuan county, Guangdong Province, China. Their structures were elucidated on the base of extensive spectroscopic ana...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1741577
更新日期:2020-03-25 00:00:00
abstract::Four C-13, C-14 side chain modified 9(R)-hydroxy-1-deoxy-taxane analogues 15, 16, 19 and 22 were semi-synthesized from 1-deoxybaccatin VI. The in vitro antitumor activity of these compounds was evaluated against A549 and A2780 cell lines. The preliminary SAR analysis showed that introduction of oxygen-containing group...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1484459
更新日期:2019-12-01 00:00:00
abstract::Diphysidione (1), a new p-hydroxyphenyl anhydride, and vitexin (2) were isolated from the leaves of Diphysa carthagenensis. The structure of the new metabolite was characterised as 4-(4-hydroxy-phenyl)-3H-pyran-2,6-dione using 1D and 2D NMR spectroscopy. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.668689
更新日期:2013-01-01 00:00:00
abstract::A new diterpenoid, 15-epi-(4E)-jatrogrossidentadione acetate, along with several known constituents has been isolated from the stem of Jatropha multifida. The structure of the new compound was settled by a detailed analysis of its 1D- and 2D-NMR spectra. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786411003792207
更新日期:2010-10-01 00:00:00
abstract::Globe artichoke has been long considered a nutraceutical food for its valuable content of bioactive compounds. However, beside a well-known polyphenol profile, poor information is available about its metabolite and mineral composition. The aim of this study was to investigate edible parts of Sicilian artichokes, 'Spin...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1258563
更新日期:2017-05-01 00:00:00