A new xanthone derivative from twigs of Garcinia nobilis.

Abstract:

:Phytochemical investigation of the twigs of Garcinia nobilis led to the isolation of a new xanthone, named l-hydroxy-2,5-dimethoxyxanthone (1), together with 15 known compounds (2-16). The structures of the new and known compounds were established by means of spectroscopic methods and by comparison with previously reported data. The structure of compound 1 was confirmed by X-ray diffraction data. Compounds 1-16 were tested for their cytotoxic activity against human cervix carcinoma cell line KB-3-1. Compounds 5 and 11 showed moderate activity while others showed weak biological activity in these cytotoxicity assays. Compounds 4 and 9 were found to be inactive.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Fouotsa H,Tatsimo SJ,Neumann B,Michalek C,Mbazoa CD,Nkengfack AE,Sewald N,Lannang AM

doi

10.1080/14786419.2014.903398

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

1030-6

issue

14

eissn

1478-6419

issn

1478-6427

journal_volume

28

pub_type

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