Abstract:
:Phytochemical investigation of the twigs of Garcinia nobilis led to the isolation of a new xanthone, named l-hydroxy-2,5-dimethoxyxanthone (1), together with 15 known compounds (2-16). The structures of the new and known compounds were established by means of spectroscopic methods and by comparison with previously reported data. The structure of compound 1 was confirmed by X-ray diffraction data. Compounds 1-16 were tested for their cytotoxic activity against human cervix carcinoma cell line KB-3-1. Compounds 5 and 11 showed moderate activity while others showed weak biological activity in these cytotoxicity assays. Compounds 4 and 9 were found to be inactive.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Fouotsa H,Tatsimo SJ,Neumann B,Michalek C,Mbazoa CD,Nkengfack AE,Sewald N,Lannang AMdoi
10.1080/14786419.2014.903398subject
Has Abstractpub_date
2014-01-01 00:00:00pages
1030-6issue
14eissn
1478-6419issn
1478-6427journal_volume
28pub_type
杂志文章abstract::Immature dendritic cells (iDCs) play very important roles in the pathological process of rheumatoid arthritis (RA). Therefore, it is urgent to search for natural products with antiproliferative activity on iDCs for anti-RA drug discovery. Erycibe schmidtii, a traditional Chinese medicine, has been used to treat RA in ...
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