Abstract:
:This work was carried out to study the effect of topical application of Andrographis paniculata on the rate of wound enclosure and its histological features. A wound was created in four groups of rat in posterior neck region. Blank placebo was applied topically to the wounds of Group 1. Groups 2 and 3 were dressed with placebo containing 5% and 10% extracts of A. paniculata, respectively. Intrasite gel was applied topically to the wounds of Group 4. Macroscopical examination revealed that the rate of wound healing was significantly accelerated in the wound dressed with A. paniculata extract compared to the blank placebo. The wounds dressed with 10% extract or Intrasite gel healed earlier compared to the wounds dressed with placebo containing 5% A. paniculata extract. Histologically, wounds dressed with A. paniculata extracts showed markedly less scar width and contained large amounts of fibroblast proliferation. More collagen and less angiogenesis with absence of inflammatory cells were seen for wounds dressed with 10% A. paniculata compared to the blank placebo. Conclusion, A. paniculata extracts significantly enhanced rate of wound healing in rats.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Al-Bayaty FH,Abdulla MA,Abu Hassan MI,Ali HMdoi
10.1080/14786419.2010.496114subject
Has Abstractpub_date
2012-01-01 00:00:00pages
423-9issue
5eissn
1478-6419issn
1478-6427pii
938527778journal_volume
26pub_type
杂志文章abstract::The aim of this study was to investigate the influence of both facility location and typology of fish farm on some ecotoxicological, qualitative and reproductive variables in European sea bass Dicentrarchus labrax L. Several variables were investigated: gonado-somatic index (GSI), liver-somatic index (LSI); 7-ethoxyre...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.678353
更新日期:2013-04-01 00:00:00
abstract::The ethanolic extract of the bulbs of Fritillaria imperialis was subjected to fractionation by solvent-solvent extraction. The nonpolar fraction showed inhibitory activity against prolyl endopeptidase (PEP) (EC.3.4.21.26), a large intracellular enzyme that preferentially hydrolyze proline-containing oligopeptidase at ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410310001643885
更新日期:2005-01-01 00:00:00
abstract::The aim of this study was to investigate mercury accumulation in some species, caught in Mediterranean Sea, in the period between May and December 2015, and to compare it to the presence of Anisakis parasites. The samples were examined by direct mercury analyzer (DMA-80) for their Hg levels. The metal concentration wa...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1230119
更新日期:2017-05-01 00:00:00
abstract::Trichosanthes dioica Roxb. (Cucurbitaceae), named 'pointed gourd' in English, is a dioecious climber grown in India. This study was aimed at evaluating the laxative activity of the aqueous extract of T. dioica root (TDA) in Swiss albino mice. The laxative activity of TDA (100 and 200 mg kg(-1) body weight per os) was ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.535161
更新日期:2012-01-01 00:00:00
abstract::Alkylglycerols (AKGs) are bioactive natural compounds that vary by alkyl chain length and degree of unsaturation, and their absolute configuration is 2S. Three AKGs (5l-5n) were synthesised in enantiomerically pure form, and were characterised for the first time together with 12 other known and naturally occurring AKG...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1686370
更新日期:2019-11-04 00:00:00
abstract::Six known metabolites, two new isocoumarins 4 and 8, and one new highly substituted benzoic acid derivative 9 were isolated from the ethyl acetate culture extract of a fungal endophyte, Scytalidium sp. In addition, another new benzoic acid 10 with an unusual 1,2-dicarbonyl side chain was indirectly identified from its...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410310001620637
更新日期:2004-06-01 00:00:00
abstract::The cholesteryl ester transfer protein (CETP), inhibition of which assists in maintaining a high level of high-density lipoprotein cholesterol in the blood, is a target for anti-atherosclerosis treatments. Orange monascus pigment was produced by a Monascus species in a 5 L jar fermenter and various derivative compound...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.905561
更新日期:2014-01-01 00:00:00
abstract::The cytotoxicity of six ent-kaurene diterpenoids isolated from the leaves of Isodon japonica (Burm.f.) Hara var. galaucocalyx (maxin) Hara was evaluated against three human tumour HepG2, GLC-82 and HL-60 cell lines through SRB assay, and their DNA damage potential (against HepG2 cell line) was assessed by comet assay....
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410802267734
更新日期:2011-09-01 00:00:00
abstract::A new protostane-type triterpenoid bearing an oxetane ring in the side-chain, named alisol W (1), has been obtained from the dried rhizome of Alisma plantago-aquatica subsp. orientale. The structure and absolute configuration of compound 1 was determined from extensive spectroscopic analysis. In addition, the vasorela...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1519710
更新日期:2019-11-01 00:00:00
abstract::The optimisation of nutritional requirements for dopamine (DA) synthesis by calcium alginate-entrapped mutant variant of Aspergillus oryzae EMS-6 using submerged fermentation technique was investigated. A total of 13 strains were isolated from soil. Isolate I-2 was selected as a better producer of DA and improved by e...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1233408
更新日期:2017-02-01 00:00:00
abstract::Phytochemical investigation of the methylenechloride/methanol extract of the aerial parts of Stachys aegyptiaca afforded a new neoclerodane-type diterpene with a new side chain 1, in addition to two known diterpenes 2 and 3 and a known flavonoid glycoside 4. The structures of the compounds were determined by comprehen...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.830217
更新日期:2014-01-01 00:00:00
abstract::A new prenylated indole alkaloid, named paraherquamide J (1), together with four known compounds (2-5), were isolated from the mangrove rhizosphere soil-derived fungus Penicillium janthinellum HK1-6. The planar structure and relative configuration of 1 were determined by detailed analysis of the spectroscopic data esp...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1534105
更新日期:2020-02-01 00:00:00
abstract::A phytochemical investigation of the MeOH extract of twigs and leaves of Tephrosia preussi was carried out to give a new kaempferol triglycoside, named tephrokaempferoside (1), together with five known compounds: tephrosin (2), betulinic acid (3), lupeol (4), β-sitosterol (5) and 3-O-β-d-glucopyranoside of β-sitostero...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1315720
更新日期:2017-11-01 00:00:00
abstract::A phytochemical investigation on Lagotis brevituba led to the isolation and characterisation of 11 phenolic compounds: p-hydroxy-benzoic acid 1, methyl 3,4-dihydroxybenzoate 2, vanillic acid 3, protocatechuic acid 4, caffeic acid 5, glucose ester of (E)-ferulic acid 6, p-coumaric acid 7, vanillin 8, diosmetin-7-O-β-d-...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1239090
更新日期:2017-02-01 00:00:00
abstract::Members of the family Zygophyllaceae are distributed in arid areas of the world and are traditionally used against various health insults ranging from skin lesions to lethal cancer. Fagonia cretica Linn. is a plant having novel compounds responsive in diseases that are still considered as incurable or are curable with...
journal_title:Natural product research
pub_type: 杂志文章,评审
doi:10.1080/14786419.2015.1036268
更新日期:2016-01-01 00:00:00
abstract::Synsepalum dulcifificum is an evergreen shrub native of tropical West Africa. It is very effective against a variety of diseases. However, the phytochemical investigation on this plant is limited till now. In our current study, seventeen compounds were isolated and identified from the ethyl acetate extract of the leav...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1830394
更新日期:2020-10-09 00:00:00
abstract::Analgesic and anti-inflammatory activities of the aqueous and ethanol extracts of Thespesia populnea Soland. ex. Correa (Malvaceae) leaves were evaluated in animal models. Orally-administered aqueous and ethanol extracts (100, 200 and 400 mg kg⁻¹ bw) showed significant analgesic activity in chemical-, mechanical- and ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.574134
更新日期:2012-01-01 00:00:00
abstract::Penicillium polonicum MCCC3A00951 is a fungus with influenza neuraminidase (NA) inhibition activity derived from a sediment of the mangrove forest of Zhangjiangkou in Fujian province, China. Chemical investigation on an ethyl acetate extract of its fermentation led to the isolation of a new compound, 7-hydroxy-3,10-de...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1817015
更新日期:2020-09-14 00:00:00
abstract::Pigeon Pea is a well-received traditional nutritious and medicinal plant in India since ancient times. The plant is identified for its impressive pharmacological activities like antimicrobial, anti-inflammatory, antitubercular, antioxidant, neuroprotective, antihypertensive, antihyperglycemic and anticancer properties...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1849197
更新日期:2020-11-23 00:00:00
abstract::The current study focuses on the chemical composition, and evaluation of antioxidant and antibacterial activity of the aerial parts of Centaurea resupinata subsp. dufourii. Using different chromatographic methods nine compounds 1-9 were isolated. The structural identification of isolated compounds was achieved using s...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1715397
更新日期:2020-01-23 00:00:00
abstract::Tectona grandis Linn (Teak), is locally known as Sagwan, belongs to Lamiaceae family. It is one of the most valuable timber in the world, due to its beautiful surface and its resistance to termite and fungal damage. The main active ingredient compounds that are responsible for these action are tectoquinone, lapachol a...
journal_title:Natural product research
pub_type: 杂志文章,评审
doi:10.1080/14786419.2018.1440217
更新日期:2019-08-01 00:00:00
abstract::A flavanone has been isolated first time from the stem of Bauhinia variegata, and its structure was identified by colour reactions and spectral analysis. In a search for novel anticancer compounds from medicinal plants, the isolated flavanone was tested for cytotoxic activity against 57 human tumour lines, representin...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410802553752
更新日期:2009-01-01 00:00:00
abstract::Development of natural nano-based plant-protection formulations represents an emerging phenomenon that has been widely improved for crops protection and for enhancing the efficiency and safety of pesticides. In the present study we isolated the essential oil from the fruits of Citrus trifoliata L. and investigated it ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1675063
更新日期:2019-10-09 00:00:00
abstract::A new chromone glycoside, 8-O-β-D-Glucopyranosyl-2-methylchromone (1), together with eight known compounds (2-9) were isolated from the Tibetan medicine plant of Swertia punicea. All compounds of this plant were reported for the first time. The structures of these metabolites were elucidated by analysis of their HR-ES...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1777123
更新日期:2020-06-11 00:00:00
abstract::Aim of the present study was to evaluate the potential beneficial and/or adverse effects of Capsicum annuum L. (cv. Fiesta) extracts at two stage of ripening (immature and mature), and at two dosages (low and high) by evaluation of biochemical profile and oxidative status in CD-1 mice. The extracts were daily administ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1525371
更新日期:2020-06-01 00:00:00
abstract::Proximate composition of the seeds and chemical analysis of the oils of Lonchocarpus sericeus and Lonchocarpus cyanescens were determined. The oil content of the seed of L. cyanescens is 29.71 ± 0.20% while that of L. sericeus is 28.00 ± 0.50%. The seeds as well as the oils of L. cyanescens and L. sericeus were found ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.643311
更新日期:2012-01-01 00:00:00
abstract::A new polycyclic polyprenylated acylphloroglucinol (1), nujiangefolin D, together with five known analogues (2-6), were isolated from the fruits of Garcinia nujiangensis. Compound 1 was screened by the LC-MS and LC-PDA. The structure of 1 was elucidated on the basis of extensive spectroscopic techniques including 1 D ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1539983
更新日期:2020-09-01 00:00:00
abstract::Cynomorium coccineum is a non-photosynthetic plant that grows in Mediterranean countries and that is amply used in the traditional medicine. The aim of this study was to extend previous studies on the chemical and biological properties of C. coccineum, evaluating the potential antiviral and antiproliferative activity ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1678613
更新日期:2019-10-17 00:00:00
abstract::Phytochemical investigation of the stem and root barks of Friesodielsia obovata Benth (Annonaceae) afforded new 3',5'-diformyl-2',4',6'-trihydroxychalcone and N-formyl-7-hydroxyglaucine together with five known compounds, 3',5'-dimethyl-2',4',6'-trihydroxychalcone, (-)-crotepoxide, demethoxymatteucinol, lawinal, and b...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701194310
更新日期:2007-09-01 00:00:00
abstract::The hexane fraction from the roots of Echinops ellenbeckii O. Hoffm. from Ethiopia yielded seven acetylenic thiophenes of which five compounds (1, 3, 4, 6, 7) are reported for the first time in this species: the monothiophenes 5-(penta-1,3-diynyl)-2-(but-3-en-1-ynyl)-thiophene (1), 5-(penta-1,3-diynyl)-2-(4-acetoxy-bu...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/1478641042000301711
更新日期:2005-12-01 00:00:00