Abstract:
:A new isocoumarin, along with 10 known compounds, was isolated from the aerial parts of Aconitum gymnandrum. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Among the known compounds, compound 11 was obtained as a natural product for the first time, which was previously reported as a synthetic product. In addition, compounds 1-5, 7 and 9 were tested for their cytotoxicity against four human cancer cell lines. The results showed that compounds 3, 4 and 7 displayed cytotoxicity against lung cancer A549 and gastric cancer MGC80, respectively, whereas 5 and 9 showed selective cytotoxicity against hepatocellular carcinoma HepG2.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Zhao JQ,Wang YM,Wang S,Dang J,Shi YP,Mei LJ,Tao YDdoi
10.1080/14786419.2015.1137574subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1746-52issue
15eissn
1478-6419issn
1478-6427journal_volume
30pub_type
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