Abstract:
:Two new flavonoid glycosides, kaempferol 3-O-α-L-rhamnopyranosyl (1→6) (3''-acetyl)-β-D-galactopyranoside 1 and kaempferol 3-O-α-L-arabinopyranosyl-5-O-α-L-rhamnopyranoside 2, along with six known ones 3-8 were isolated from the flowers of Vicia faba L. (Fabaceae). Methanol extract and the isolated compounds were tested against lipase and melanogenesis inhibition activities and resulted in that compound 2 showed 53 and 77% lipase inhibition activity in concentrations of 400 and 800 μg/mL, respectively. For melanogenesis, compounds 2, 3 and 4 exhibited potent melanogenesis inhibition activity where the melanin content in melanoma cells was decreased to be about 57.5, 56 and 61%, respectively, with no obvious melanocytotoxicity. The rest of compounds showed weak to moderate activity. The results of melanogenesis inhibition activity of this study suggested the potential use of Vicia faba flowers as a skin-whitening agent and reveal the flowers to be a rich source of important phytochemicals with antilipase and melanogenesis inhibitory activity.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Allam AE,Nafady AM,Nakagawa T,Takemoto N,Shimizu Kdoi
10.1080/14786419.2017.1359169subject
Has Abstractpub_date
2018-08-01 00:00:00pages
1920-1925issue
16eissn
1478-6419issn
1478-6427journal_volume
32pub_type
杂志文章abstract::A new γ-pyrone derivative, acrepyrone A (1), and three known sorbicillinoids, trichodimerol (2), dihydrotrichodimerol (3) and tetrahydrotrichodimerol (4) were isolated from an endophytic fungus, Acremonium citrinum SS-g13, harboured in the roots of the Chinese medicinal plant Fructus mori. Their structures were determ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1548462
更新日期:2020-04-01 00:00:00
abstract::Colletia paradoxa (Spreng.) Esc. (Rhamnaceae, Colletieae) is a medicinal plant, threatened with extinction in Brazil, presenting great morphological variability. Our objective is to investigate the phytochemical components, antioxidant capacity and antimycobacterial activity of different morphotypes of C. paradoxa in ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1598987
更新日期:2019-04-16 00:00:00
abstract::In order to identify genes related to Taxol biosynthesis, the mRNA differential display method was employed to compare mRNA populations from suspension cultured Taxus chinensis cells before and after beginning to produce Taxol. From a total display of about 4000 PCR products, 104 were derived from cells during the Tax...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410310001630573
更新日期:2004-08-01 00:00:00
abstract::(+) Benzomalvins E (1) and (-) Benzomalvins E (2), a pair of epimeric derivatives, together with three known benzomalvins (3-5), were isolated from solid cultures of a interrhizospheric fungus Penicillium sp. SYPF 8411. The planar structure of (+) Benzomalvins E (1) has been previously reported. While, the absolute co...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1569004
更新日期:2020-07-01 00:00:00
abstract::SPME analysis of Zingiber officinale Roscoe and Curcuma longa L. were performed by using a DVB/CARB/PDMS fiber. The SPME analysis of Zingiber officinale showed that the main components found were camphene (7.27%), geranial (8.37%), α-zingiberene (14.50%), α-farnesene (9.14%), β-bisabolene (6.52%), and β-sesquiphelland...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1488702
更新日期:2019-07-01 00:00:00
abstract::The ethanol extract of Stellera chamaejasme roots exhibited significant bioactivity against Peries rapae. In the course of a search for the active compounds, S-(+)-1,5-diphenyl-3-hydroxy-1-pentanone (1) was isolated and this compound has never been found before in S. chamaejasme as far as we known. The structure was e...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701782536
更新日期:2008-03-10 00:00:00
abstract::A new compound decomposed from ginkgolide B(GB) is discovered and identified by MS and UV spectrum. It is the dehydrate of GB, which was named as ginkgolide K before. Differently, it cannot exist independently, but only in equilibrium with GB. It is found first time that 3-hydroxy is active in some solvent. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410601130547
更新日期:2008-01-01 00:00:00
abstract::Natural products represent a rich source of bioactive compounds that have been historically used to obtain substances with great medicinal potential. The skin of anuran amphibians is a rich source of compounds with a wide range of biological activity. Alzheimer's disease (AD) is a complex disease associated with all k...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1591396
更新日期:2019-03-31 00:00:00
abstract::A high performance liquid chromatography-time-of-flight-mass spectrometry (HPLC-TOF-MS) method was developed for analysing the chemical constituents in Hedyotis diffusa, which is widely used as a traditional Chinese medicine (TCM) in the field of cancer treatment. The compounds were identified either by comparing the ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.537275
更新日期:2012-01-01 00:00:00
abstract::The objective of this work was to produce and characterise nanoemulsions containing tucumã extract and to evaluate the performance of the nanostructure and the free compound regarding antitumor activity, cytotoxicity, and oxidative metabolism in NB4/APL cells. The nanoemulsions showed adequate physicochemical characte...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1862830
更新日期:2020-12-24 00:00:00
abstract::A phytochemical investigation of the MeOH extract of twigs and leaves of Tephrosia preussi was carried out to give a new kaempferol triglycoside, named tephrokaempferoside (1), together with five known compounds: tephrosin (2), betulinic acid (3), lupeol (4), β-sitosterol (5) and 3-O-β-d-glucopyranoside of β-sitostero...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1315720
更新日期:2017-11-01 00:00:00
abstract::Cochliomycin G (1), a new 14-membered resorcylic acid lactone, together with six known analogues (2-7), was isolated from the culture broth of a marine-derived fungus Cochliobolus lunatus. The planar structure of 1 was established by extensive NMR spectroscopy, and the absolute configuration was elucidated by the comb...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1633646
更新日期:2021-02-01 00:00:00
abstract::Phorbol esters (PEs) are diterpenes present in Jatropha curcas L. seeds and have a myriad of biological activities. Since PEs are toxic, they are considered to be futile in Jatropha-based biodiesel production chain. In the present study, the extracted PEs from Jatropha oil were used as a starting material to synthesis...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.716057
更新日期:2013-01-01 00:00:00
abstract::Endophytic fungi represent ubiquitous microbial organisms able to live in the tissues of different plants around the world and represent a prolific source of bioactive metabolites. In the present study, the endophytic fungus Aspergillus calidoustus was isolated from the medicinal plant Acanthospermum australe (Asterac...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1022777
更新日期:2016-01-01 00:00:00
abstract::Cynomorium coccineum is a non-photosynthetic plant that grows in Mediterranean countries and that is amply used in the traditional medicine. The aim of this study was to extend previous studies on the chemical and biological properties of C. coccineum, evaluating the potential antiviral and antiproliferative activity ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1678613
更新日期:2019-10-17 00:00:00
abstract::Salvia x jamensis J. Compton is a hybrid between Salvia greggii A. Gray and Salvia microphylla Kunt. In this study, we describe three hair types identified by Scanning Electron Microscopy. In the essential oil of the aerial parts of S. jamensis 56 different compounds were identified. The two main constituents were β-c...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.730044
更新日期:2013-01-01 00:00:00
abstract::Eight phenolic compounds, including two mixtures of two compounds, were isolated from the ethyl acetate extract of leaves and stems of Homalium brachybotrys. They were identified on the basis of spectroscopic data as quercetin-3-O-beta-glucopyranoside, luteolin-7-O-beta-glucopyranoside, 5,6-dihydro-6-beta-glucopyranos...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410601130679
更新日期:2007-11-01 00:00:00
abstract::The world's rainforests hold untold potential for drug discovery. Rainforest plants are thought to contain evolved defensive active metabolites of greater diversity compared to plants from temperate regions. In recent years, the interest and overall output from pharmaceutical companies on novel antibacterial agents ha...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.537274
更新日期:2011-11-01 00:00:00
abstract::A novel oxime polyketide, maydisone (1), along with two known compounds, 7-hydroxy-2,5-dimethylchromone (2) and 2,5-dimethylbenzoic acid (3) were isolated from the cultures of Bipolaris maydis. Their structures were identified by the application of NMR and MS data analyses and comparison with previous reports. Compoun...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1765339
更新日期:2020-05-13 00:00:00
abstract::To search for antifungal leads, the metabolites of an insect-derived fungus Fusarium lateritium ZMT01 were investigated, providing five sesquiterpenes (1-5), including new molecules microsphaeropsisins D and E (1 and 2). The evaluated antifungal activities in vitro which are higher than the positive control triadimefo...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2021.1872569
更新日期:2021-01-15 00:00:00
abstract::The chemical investigation of the leaves and stem bark of Acacia polyacantha (Fabaceae) led to the isolation of a new oleanane-type triterpenoid saponin named polyacanthoside A 1 together with fifteen known compounds. Their structures were established from spectral , mainly HRESIMS, 1D NMR and 2D NMR and by comparison...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1486312
更新日期:2019-12-01 00:00:00
abstract::Although Origanum vulgare (L.) has been deeply analysed at phytochemical level, poor knowledge is available regarding non-volatile compounds such as lipids. The aim of this work was to characterise five wild Sicilian Origanum ecotypes from an agronomic, metabolomic and lipidomic perspective. Serradifalco presented hig...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1104672
更新日期:2016-01-01 00:00:00
abstract::The aryltetralin lignans 6-methoxypodophyllotoxin, 5'-demethoxy-6-methoxypodophyllotoxin as well as the corresponding 8'-epimers 6-methoxypicropodophyllin, and 5'-demethoxy-6-methoxypicropodophyllin were isolated from suspension cultures of Linum cariense, and 4'-demethyl-6-methoxypodophyllotoxin together with 6-metho...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410600798385
更新日期:2007-01-01 00:00:00
abstract::Natural estrogens have demonstrated a wide variety of biological activities, which makes them a good candidate for the treatment of diabetes. In vitro, this study evidenced that isoflavones enhanced insulin secretion and inhibited α-amylase activity. In vivo, the findings indicated that soy isoflavones stimulated insu...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786411003683117
更新日期:2011-02-01 00:00:00
abstract::In Lithuania, two species of the genus Fragaria L. (Rosaceae), F. vesca L. and F. viridis Weston, occur naturally in the wild and two others, F. moschata Weston and F. × ananassa Duchesne ex Rozier are found escaped from cultivation. The main objective of this study was to establish the variation pattern in the conten...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.660634
更新日期:2013-01-01 00:00:00
abstract::Chemical investigation of Dendrobium plicatile Lindl resulted in the isolation and identification of one new bibenzyl, 2-chloro-3, 4'-dihydroxy-3',5-dimethoxybibenzyl (1), as well as 15 known stilbenoids. The structures of this new compound was elucidated by extensive spectroscopic analysis, including HRESIMS, 1H and ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1530996
更新日期:2020-02-01 00:00:00
abstract::Comparison of an authentic sample of altertenuol with altenuisol obtained by total synthesis and analysis of nuclear magnetic resonance spectra unambiguously revealed that altertenuol and altenuisol are identical compounds. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2013.819509
更新日期:2013-01-01 00:00:00
abstract::A new denudatine-type C20-diterpenoid alkaloid, designated as sinchianine (1), together with eight known diterpenoid alkaloids, 12-acetyl-12-epi-napelline (2), 12-epi-napelline (3), neoline (4), talatisamine (5), 14-O-acetylsenbusine A (6) and benzoylaconine (7), songorine (8) and aconitine (9), were isolated from the...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1410814
更新日期:2018-10-01 00:00:00
abstract::Two new myrsinol-type diterpene polyesters 3,5,13,17-tetra-O-acetyl-7-O-benzoyl-15-hydroxymyrsinol (1) and 3,5,13,17-tetra-O-acetyl-7-O-butanoyl-13-hydroxymyrsinol (2), with a tricyclic carbon skeleton have been isolated from Euphorbia decipiens Boiss. & Buhse. The structure elucidation of the isolated compounds was b...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410410001714687
更新日期:2005-04-01 00:00:00
abstract::A new oleanolic-type triterpene glycoside, (3β,21β)-21-[(β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl)oxy]-3-hydroxyolean-12-en-28-oic acid (1), together with five analogues, oleanazuroside 1 (2), oleanazuroside 2 (3), 24-hydroxytormentic acid ester glucoside (4), 24-epi-pinfaensin (5), and oleanolic acid 3-O-α-l-arabi...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1258557
更新日期:2017-04-01 00:00:00