Effect of polyphenols from Vicia faba L on lipase activity and melanogenesis.

Abstract:

:Two new flavonoid glycosides, kaempferol 3-O-α-L-rhamnopyranosyl (1→6) (3''-acetyl)-β-D-galactopyranoside 1 and kaempferol 3-O-α-L-arabinopyranosyl-5-O-α-L-rhamnopyranoside 2, along with six known ones 3-8 were isolated from the flowers of Vicia faba L. (Fabaceae). Methanol extract and the isolated compounds were tested against lipase and melanogenesis inhibition activities and resulted in that compound 2 showed 53 and 77% lipase inhibition activity in concentrations of 400 and 800 μg/mL, respectively. For melanogenesis, compounds 2, 3 and 4 exhibited potent melanogenesis inhibition activity where the melanin content in melanoma cells was decreased to be about 57.5, 56 and 61%, respectively, with no obvious melanocytotoxicity. The rest of compounds showed weak to moderate activity. The results of melanogenesis inhibition activity of this study suggested the potential use of Vicia faba flowers as a skin-whitening agent and reveal the flowers to be a rich source of important phytochemicals with antilipase and melanogenesis inhibitory activity.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Allam AE,Nafady AM,Nakagawa T,Takemoto N,Shimizu K

doi

10.1080/14786419.2017.1359169

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

1920-1925

issue

16

eissn

1478-6419

issn

1478-6427

journal_volume

32

pub_type

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