Stilbenoids from aerial parts of Dendrobium plicatile.

Abstract:

:Chemical investigation of Dendrobium plicatile Lindl resulted in the isolation and identification of one new bibenzyl, 2-chloro-3, 4'-dihydroxy-3',5-dimethoxybibenzyl (1), as well as 15 known stilbenoids. The structures of this new compound was elucidated by extensive spectroscopic analysis, including HRESIMS, 1H and 13C NMR, DEPT, HMBC, COSY, HMQC, NOESY. Compounds 2, 3 and 5 were obtained from this genus for the first time, compounds 8, 10, 13 and 14 were obtained from this plant for the first time. In addition, the new compound exhibited potent cytotoxic activities against the human breast cancer (MDA-MB231) cell line, the hepatocellular carcinoma (HepG2) cell line and the human lung carcinoma (A549) cell line, with IC50 3.41, 3.02, 2.80 μM, respectively.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Chen DN,Wang YY,Liu WJ,Chen YJ,Wu YP,Wang JX,He F,Jiang L

doi

10.1080/14786419.2018.1530996

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

323-328

issue

3

eissn

1478-6419

issn

1478-6427

journal_volume

34

pub_type

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