Abstract:
:Juniperus chinensis cv. Kaizuca has extensive pharmacological activities. The cone oils exhibited protein tyrosine phosphatase 1B inhibitory activity in vitro. The IC50 value was 4.49 ± 0.04 μg/mL. A total of 17 compounds were characterised from the cone oils by GC-MS. In order to explain the activity against protein tyrosine phosphatase 1B, the identified compounds from cone oils were individually docked with the protein tyrosine phosphatase 1B protein by virtual molecular docking. As a result, thunbergene was completely wrapped by the active site of protein tyrosine phosphatase 1B, and its binding energy was -6.41 kcal/mol. The result indicated that thunbergene possessed the potential protein tyrosine phosphatase 1B inhibitory activity, which may be responsible for the activity of cone oils.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Fang C,Gu D,Yang J,Li M,Liu H,Yang Ydoi
10.1080/14786419.2017.1374267subject
Has Abstractpub_date
2018-11-01 00:00:00pages
2709-2711issue
22eissn
1478-6419issn
1478-6427journal_volume
32pub_type
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