Abstract:
:Tryptamine derivatives such as tryptamine and bacillamides were strong algicidal compounds promising in controlling harmful algae blooms, but their bioactivity and application researches were hindered by extremely low natural production rates. This study found an induced production of algicidal tryptamine derivatives by co-culture of marine Streptomyces with Bacillus mycoides, and optimised the culture method through changing important factors such as medium nutrition content, culture mode and pH value. The final established co-culture method used only 5 g yeast extracts and 5 g glycerol in 1 L 75% sea water, but got a yield of 14.9 mg/L N-acetyltryptamine, 2.8 mg/L N-propanoyltryptamine, 3.0 mg/L bacillamide A, 13.7 mg/L bacillamide B and 9.6 mg/L bacillamide C, which were all undetectable under normal culture conditions.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Yu L,Hu Z,Ma Zdoi
10.1080/14786419.2015.1005619subject
Has Abstractpub_date
2015-01-01 00:00:00pages
2087-91issue
22eissn
1478-6419issn
1478-6427journal_volume
29pub_type
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