Abstract:
:The lipid peroxidation inhibitory activities of four hydroxyxanthones, isolated from the whole plant Swertia decussata, were evaluated for the first time. The most promising antioxidant among the xanthones, 1,7,8-trihydroxy-3-methoxyxanthone (swertianine, 4) was also tested for its scavenging potential against DPPH and superoxide radicals. The data clearly revealed good antioxidant activity of the xanthones, especially 4 which also showed strong protection against y-ray induced pBR322 DNA damage. A comparison of the radioprotecting activities of the monomethylated tetrahydroxyxanthone 4 with that of its congener, 1,3,7-trihydroxy-8-methoxyxanthone (5) revealed that the radioprotecting activity was not affected by the position of methylation.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Patro BS,Chintalwar GJ,Chattopadhyay Sdoi
10.1080/14786410412331280032keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
347-54issue
4eissn
1478-6419issn
1478-6427journal_volume
19pub_type
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