Discovery of a new biphenyl derivative by epigenetic manipulation of marine-derived fungus Aspergillus versicolor.

Abstract:

:Cultivation of the marine-derived Aspergillus versicolor MCCC 3A00080 with the addition of a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), significantly enhanced the diversity of secondary metabolites. From the culture treated, a new biphenyl derivative, named versiperol A (1), along with two known compounds, 2,4-dimethoxyphenol (2) and diorcinol (3) were isolated. The structures of 1-3 were established based on spectroscopic analysis and comparison with literature data. Among the isolates, versiperol A (1) exhibited modest inhibition of Staphylococcus aureus growth with MIC value of 8 μg/mL.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Zhu JX,Ding L,He S

doi

10.1080/14786419.2018.1465423

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

1191-1195

issue

8

eissn

1478-6419

issn

1478-6427

journal_volume

33

pub_type

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