Abstract:
:Cultivation of the marine-derived Aspergillus versicolor MCCC 3A00080 with the addition of a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), significantly enhanced the diversity of secondary metabolites. From the culture treated, a new biphenyl derivative, named versiperol A (1), along with two known compounds, 2,4-dimethoxyphenol (2) and diorcinol (3) were isolated. The structures of 1-3 were established based on spectroscopic analysis and comparison with literature data. Among the isolates, versiperol A (1) exhibited modest inhibition of Staphylococcus aureus growth with MIC value of 8 μg/mL.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Zhu JX,Ding L,He Sdoi
10.1080/14786419.2018.1465423subject
Has Abstractpub_date
2019-04-01 00:00:00pages
1191-1195issue
8eissn
1478-6419issn
1478-6427journal_volume
33pub_type
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