Abstract：
:Two new sphingofungins G (1) and H (2) with a five-membered lactone ring were identified from the solid-state fermentation of Aspergillus penicilliodes Speg., a dominant microorganism isolated previously from the post-fermentation of ripe Pu-er tea, together with six known metabolites. Their structures were elucidated by extensive spectroscopic methods. All of them were isolated from the mycelia culture of A. penicilliodes for the first time. The known compound, trypacidin, exhibited potent cytotoxities against five human cancer cell lines, e.g. myeloid leukemia HL-60, lung cancer A-549, hepatocellular carcinoma SMMC7721, breast cancer MCF-7, and colon cancer SW480, with IC50 values of 0.55, 11.45, 10.95, 3.58, and 3.49 μM, resp., while cisplatin as the positive control, with IC50 values of 8.63, 24.15, 21.99, 27.29, and 23.61 μM, resp.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Zhang H,Zhu HT,Wang D,Yang CR,Zhang YJdoi
10.1080/14786419.2018.1470627subject
Has Abstractpub_date
2019-05-01 00:00:00pages
1284-1291issue
9eissn
1478-6419issn
1478-6427journal_volume
33pub_type
杂志文章abstract：:The isolation from olive pulp of a diacylglycerol showing an oleic as well as an elenoic acid residue, the latter probably derived from a natural enzymatic oleuropein hydrolysis, is reported. The given structure is supported by 1H- and 13C-NMR data. ...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786410410001686382
更新日期：2005-01-01 00:00:00
abstract：:A new phenolic glycoside, 6-O-(4'-hydroxy-3',5'-dimethoxybenzoyl)-d-glucopyranose (4), and nine known compounds (1-3 and 5-10) were isolated from Juglans mandshurica Maxim. Compound structures were elucidated by NMR, HR-ESI-MS and acid hydrolysis. Compounds 5 and 6 are reported from this genus for the first time. Amon...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2014.902946
更新日期：2014-01-01 00:00:00
abstract：:Oleiferoside B is a triterpenoid monomer compound, mainly isolated from roots of Camellia oleifera Abel, the underlying mechanism of its antitumour is not clear. In the present study, oleiferoside B potently inhibited SMMC-7721 and MCF-7 cells proliferation and cause cells apoptosis. In addition, it activated an autop...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2020.1739039
更新日期：2020-03-18 00:00:00
abstract：:A new highly oxygenated germacranolide, carcerlane A (1), together with four known highly oxygenated germacranolides (2-5), was isolated from an ethanol extract of the whole plant of Carpesium nepalense var. lanatum (C.B.Clarke) Kitam. The structures were determined by HRESIMS and extensive analysis of their spectrosc...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2020.1833199
更新日期：2020-10-22 00:00:00
abstract：:In the present investigation, the anti-inflammatory activity of a polyphenolic enriched extract of Schima wallichii bark was evaluated in vitro using human peripheral blood mononuclear cells (PBMCs) and in vivo by carrageenan-induced paw oedema assay (acute study) and cotton pallet granuloma assay (chronic study). The...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786410802560732
更新日期：2011-04-01 00:00:00
abstract：:A series of novel hydrocarbylidene nitrohydrazinecarboximidamides were designed and synthesized using an insecticidal natural product Galegine as a lead compound. The bioassay results show that the target compounds exhibited moderate to good insecticidal activities against Hyalopterus pruni Geoffroy at a concentration...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2019.1655409
更新日期：2019-08-20 00:00:00
abstract：:The antibacterial activity of essential oil and methanolic extract of Teucrium polium was determined against Pseudomonas aeruginosa, Pantoea agglomerans, Brenneria nigrifluens, Rhizobium radiobacter, Rhizobium vitis, Streptomyces scabies, Ralstonia solanacearum, Xanthomonas campestris and Pectobacterium cartovorum by ...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2014.1000320
更新日期：2015-01-01 00:00:00
abstract：:Physalis angulata is an annual herb which has tremendous medicinal uses. The antioxidant activity of the whole plant extract of Physalis angulata was investigated using DPPH radical scavenging activity. Purified compounds were isolated using column chromatography method. Their structures were determined using various ...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2020.1844691
更新日期：2020-11-23 00:00:00
abstract：:Three new diterpenoids, liquidambolide A (1) and liquiditerpenoic acids A (2) and B (3), together with 10 known diterpenes were isolated from the resin of Liquidambar formosana Hance, whose structures were elucidated by detailed analysis on the NMR and HR-ESI-MS spectra. ...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2013.825915
更新日期：2014-01-01 00:00:00
abstract：:The stem bark of Cussonia bancoensis is used traditionally for the treatment of different types of infection and pain. A bioassay guided fractionation of the methanol stem bark extract led to the isolation of five pentacyclic triterpenes and glycosides identified based on spectroscopic data as 23-hydroxyursolic acid (...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2018.1503262
更新日期：2020-03-01 00:00:00
abstract：:Chemical investigation of the resinous exudates of Commiphora myrrha has led to the isolation of four sesquiterpenes (1a/1b, 2, and 3), including one pair of new sesquiterpene enantiomers (1a/1b), one new racemic mixture 2, and two steroids (4 and 5). Their structures were elucidated by spectroscopic analysis, and the...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2018.1448811
更新日期：2019-02-01 00:00:00
abstract：:The subfamily Asclepiadoideae (Apocynaceae) and the closely-related Periplocoideae are sources of many indigenous Indian medicinal plants. We surveyed antioxidant properties and total phenolic and flavonoid contents of 15 samples, representing 12 Indian medicinal plant species from these subfamilies. Total antioxidant...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786410802228827
更新日期：2010-02-01 00:00:00
abstract：:Salvia apiana (white sage, Lamiaceae family) plant is native to southern California and parts of Mexico. Some Native American tribes local to this region consider S. apiana to be sacred and burn the leaves as incense for purification ceremonies. The plant has been used to treat sore throats, coughs, chest colds, upper...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2016.1269096
更新日期：2017-09-01 00:00:00
abstract：:GC/FID and GC-MS analysis revealed germacrene D, bicyclogermacrene, α-cadinol and cubenol as major compounds from aril. Germacrene D, bicyclogermacrene, trans-caryophyllene and δ-elemene are major compounds in fruits. Germacrene D, spathulenol, trans-caryophyllene and caryophyllene oxide are major compounds in leaves....
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2014.987145
更新日期：2015-01-01 00:00:00
abstract：:A new monoterpenoid indole alkaloid compound (1) and six known monoterpenoid indole alkaloids compounds (2-7) were isolated from the barks of Voacanga africana Staph. The structures were established by spectral analysis as ibogamine-16-carboxylic acid,17,20-didehydro-5,6-dioxo-10-methoxy-methyl ester (1), voacamine (2...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2015.1046132
更新日期：2016-01-01 00:00:00
abstract：:Synsepalum dulcifificum is an evergreen shrub native of tropical West Africa. It is very effective against a variety of diseases. However, the phytochemical investigation on this plant is limited till now. In our current study, seventeen compounds were isolated and identified from the ethyl acetate extract of the leav...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2020.1830394
更新日期：2020-10-09 00:00:00
abstract：:Alkaloids and phenolic compounds are among the most biologically active natural products from the Jacobaea/Senecio genera (Asteraceae). To isolate original natural products directly from Jacobaea gigantea crude polar extracts, centrifugal partition chromatography (CPC) was used. Previously, we reported the phytochemic...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2018.1493584
更新日期：2019-08-01 00:00:00
abstract：:Waste deriving from food and agro-industries is a growing problem in our modern society. In order to reduce food waste and its associated impacts over the environment and public health, innovative strategies for the conversion of food wastes in added value products are studied. Whey is one of the prominent waste deriv...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2017.1385024
更新日期：2018-07-01 00:00:00
abstract：:Fruits of different Sorbus L. species have been traditionally used in food production and in the treatment of various ailments. Besides common antioxidant active phytochemicals such as ascorbic acid, tocopherols and carotenoids, fruits are rich in phenolic compounds that are of particular interest. In this study, prof...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2014.895727
更新日期：2014-01-01 00:00:00
abstract：:This paper aims to investigate, for the first time, physicochemical characteristics and antioxidant capacity of Psidium myrtoides ripe and unripe fruit. In addition, essential oil was extracted from fresh leaves (PM-EO) collected in dry and rainy seasons to investigate the influence of seasonality and, after that, to ...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2020.1844689
更新日期：2020-11-09 00:00:00
abstract：:Alkylglycerols (AKGs) are bioactive natural compounds that vary by alkyl chain length and degree of unsaturation, and their absolute configuration is 2S. Three AKGs (5l-5n) were synthesised in enantiomerically pure form, and were characterised for the first time together with 12 other known and naturally occurring AKG...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2019.1686370
更新日期：2019-11-04 00:00:00
abstract：:The search for bioactive compounds against diseases is imperative and the richness of the Amazon provides a large source to be explored. Current therapies for the treatment of parasitic infections have severe side effects and low efficacy, which makes the development of an effective chemotherapy extremely important. I...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2020.1715395
更新日期：2020-01-25 00:00:00
abstract：:Cumin (Cuminum cyminum) is an annual plant from Apiaceae family that is cultivated in Iran as landraces. The most important chemical composition of the cumin essential oil was cuminaldehyde. In this research, the effect of different landraces and growth regulators was evaluated on callus induction, and best callus was...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2016.1272105
更新日期：2017-09-01 00:00:00
abstract：:The chemical composition of the volatile organic compounds (VOCs) released from the leaves and flowers of Artemisia fragrans Willd. (Asteraceae) was investigated using headspace solid-phase microextraction (HS-SPME) coupled to gas chromatography (GC) and/or GS/mass spectrometry (GC/MS). The efficiency and reliability ...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786410903108951
更新日期：2010-08-01 00:00:00
abstract：:Teucrium marum and T. subspinosum have been extracted with different polarity solvents, each crude extract was analysed with (1)H-NMR to compare the overall metabolic component. The polar extracts showed antioxidant activity in vitro. Verbascoside and arabinosyl-verbascoside were isolated and identified. Their concent...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786410701571384
更新日期：2007-10-01 00:00:00
abstract：:Platelet aggregation is fundamental to a wide range of physiological and pathological processes, including the induction of thrombosis and arteriosclerosis. Anti-platelet activity of a crude methanol extract and solvent fractions of Ashitaba roots (Angelica keiskei Koidz.) was evaluated using a turbidimetric method us...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2014.931389
更新日期：2014-01-01 00:00:00
abstract：:A high performance liquid chromatography-time-of-flight-mass spectrometry (HPLC-TOF-MS) method was developed for analysing the chemical constituents in Hedyotis diffusa, which is widely used as a traditional Chinese medicine (TCM) in the field of cancer treatment. The compounds were identified either by comparing the ...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2010.537275
更新日期：2012-01-01 00:00:00
abstract：:Chromatographic fractionation of the chloroform extracts from the stem bark and stems of Guettarda grazielae resulted in the isolation of a new iridoid (guettardodiol, 1) and the secoiridoid sarracenin (2), described for the first time in this genus. The structural elucidation of these compounds was based on spectrosc...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2010.507547
更新日期：2011-10-01 00:00:00
abstract：:Protein kinase C (PKC) plays a key role in neurotransmission in the central nervous system, and targeting PKC domain is considered as a strategy to modulate the anaesthetic effects. In this study, we described a synthetic pipeline to perform high-throughput virtual screening against a large library of 3D structural na...
journal_title：Natural product research
pub_type： 杂志文章
doi：10.1080/14786419.2014.955491
更新日期：2015-01-01 00:00:00
abstract：:32 medicinal plants that are unique to the Russian Pharmacopeia have 693 isolated natural products associated with them (an average of 21.66 compounds per plant). This is in contrast to the US Pharmacopeia plants that have delivered 2366 known natural products (an average of 42.25 compounds per plant). ...
journal_title：Natural product research
pub_type： 信件
doi：10.1080/14786419.2020.1727474
更新日期：2020-02-21 00:00:00
