Abstract:
:A new monoterpenoid indole alkaloid compound (1) and six known monoterpenoid indole alkaloids compounds (2-7) were isolated from the barks of Voacanga africana Staph. The structures were established by spectral analysis as ibogamine-16-carboxylic acid,17,20-didehydro-5,6-dioxo-10-methoxy-methyl ester (1), voacamine (2), vobasine (3), voacangine (4), voacristine (5), 19-epi-voacristine (6) and 19-epi-heyneanine (7). Compound 1 was confirmed by X-ray crystallographic analysis. All of the isolated compounds were evaluated for cytotoxicity against five cell lines (HEPG-2, A375, MDA-MB-231, SH-SY5Y, CT26). Among them, compounds 2 and 6 displayed significant inhibitory activities, compounds 3, 4 and 5 showed moderate inhibitory activities, while compounds 1 and 7 showed no inhibitory activities against the five cell lines.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Chen HM,Yang YT,Li HX,Cao ZX,Dan XM,Mei L,Guo DL,Song CX,Dai Y,Hu J,Deng Ydoi
10.1080/14786419.2015.1046132subject
Has Abstractpub_date
2016-01-01 00:00:00pages
1144-9issue
10eissn
1478-6419issn
1478-6427journal_volume
30pub_type
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