Abstract:
:Protein kinase C (PKC) plays a key role in neurotransmission in the central nervous system, and targeting PKC domain is considered as a strategy to modulate the anaesthetic effects. In this study, we described a synthetic pipeline to perform high-throughput virtual screening against a large library of 3D structural natural products released recently in order to discover those potential PKC modulators. A total of 100 natural products with top scores were raised, from which 12 promising candidates were tested to determine their inhibitory potencies against PKC. As might be expected, the promiscuous kinase inhibitor staurosporine showed a high PKC inhibitory activity (IC50 = 64 nM), and other two tested compounds, i.e. fisetin and tetrahydropapaverine, were also highly potent with their activities at nanomolar level (IC50 = 370 and 190, respectively).
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Zhao J,Zhou Cdoi
10.1080/14786419.2014.955491subject
Has Abstractpub_date
2015-01-01 00:00:00pages
589-91issue
6eissn
1478-6419issn
1478-6427journal_volume
29pub_type
杂志文章abstract::Mahuang Fuzi Xixin (MFX), a classic recipe in traditional Chinese medicine, belongs to an exterior-relieving formula. For quality control of the MFX products, qualitative analysis using ultra-high performance liquid chromatography with diode-array detector-tandem mass spectrometry (UPLC-PDA-MS/MS) was undertaken. Six ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.983104
更新日期:2015-01-01 00:00:00
abstract::EU and Italian laws dealing for the presence of antibiotics or, more in general, drags in food established limits for different kinds of food. Suitable rules exist about the medical treatment of cattle in relation to the production of milk and meat. The adoption of a procedure to check the respect of the law limits is...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1392951
更新日期:2018-07-01 00:00:00
abstract::Cochliomycin G (1), a new 14-membered resorcylic acid lactone, together with six known analogues (2-7), was isolated from the culture broth of a marine-derived fungus Cochliobolus lunatus. The planar structure of 1 was established by extensive NMR spectroscopy, and the absolute configuration was elucidated by the comb...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1633646
更新日期:2021-02-01 00:00:00
abstract::Chemical investigation of the resinous exudates of Commiphora myrrha has led to the isolation of four sesquiterpenes (1a/1b, 2, and 3), including one pair of new sesquiterpene enantiomers (1a/1b), one new racemic mixture 2, and two steroids (4 and 5). Their structures were elucidated by spectroscopic analysis, and the...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1448811
更新日期:2019-02-01 00:00:00
abstract::The cytotoxicity of six ent-kaurene diterpenoids isolated from the leaves of Isodon japonica (Burm.f.) Hara var. galaucocalyx (maxin) Hara was evaluated against three human tumour HepG2, GLC-82 and HL-60 cell lines through SRB assay, and their DNA damage potential (against HepG2 cell line) was assessed by comet assay....
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410802267734
更新日期:2011-09-01 00:00:00
abstract::Leishmaniasis is caused by parasites of the genus Leishmania. Recent reports about leishmaniasis show a few number of drugs available, indicating the necessity of new drugs. In this study, the ethanol extract and fractions of Pityrogramma calomelanos (L.) link. (Pteridaceae) were assayed to verify the cytotoxicity and...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.686911
更新日期:2013-01-01 00:00:00
abstract::A new flavanone glycoside, (2S)-dihydrooroxylin A 7-O-[β-D-apiosyl(1 → 2)]-β-D-glucoside (1), and four known compounds (2-5) were isolated from Tournefortia sibirica L. The chemical structures of these compounds were determined by 1 D and 2 D NMR and HR-ESI-MS spectra, and r...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1512995
更新日期:2019-10-01 00:00:00
abstract::This study reports for the first time in the chemical composition of acetone, ether, ethyl acetate and dichloromethane extracts of Hypogymnia tubulosa determined by HPLC-UV, GC-FID and GC-MS as well as effect of H. tubulosa acetone extract on micronucleus distribution on human lymphocytes and on cholinesterase activit...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1375926
更新日期:2018-11-01 00:00:00
abstract::The aryltetralin lignans 6-methoxypodophyllotoxin, 5'-demethoxy-6-methoxypodophyllotoxin as well as the corresponding 8'-epimers 6-methoxypicropodophyllin, and 5'-demethoxy-6-methoxypicropodophyllin were isolated from suspension cultures of Linum cariense, and 4'-demethyl-6-methoxypodophyllotoxin together with 6-metho...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410600798385
更新日期:2007-01-01 00:00:00
abstract::A new oleanane triterpenoid (2) was isolated from the roots of Rubia philippinensis. The structure of 2 was determined by analysis of HRMS and NMR data and identified as a rubiprasin analogue, 16β-hydroxyrubiprasin B. Four related known compounds were also encountered which include rubiprasin B (1), maslinic acid (3),...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1645656
更新日期:2019-07-25 00:00:00
abstract::One new furofuran lignan 2-methoxy-9β-hydroxydiasesamin (1), and four analogues (2-5), together with eight alkaloids (6-13), were isolated from the ethanol extract of the aerial part of Clinacanthus nutans. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. All the compounds...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1475375
更新日期:2019-05-01 00:00:00
abstract::The chemical composition of the essential oil (EO) obtained from the aerial parts of Rydingia michauxii (Briq.) Scheen & V.A. Albert was analysed by gas chromatography and gas chromatography/mass spectrometry (GC/MS). Eighty components were identified in the oil with caryophyllene oxide (20.1%), trans-verbenol (10.2%)...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1343321
更新日期:2018-01-01 00:00:00
abstract::The Aedes aegypti mosquito is one of the major vectors of arboviruses. These diseases have re-emerged and the insecticides used nowadays are toxic to mammals and environment and have only been effective in the short-term. In this context, natural products are an alternative. The genus Piper has many active compounds a...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1374265
更新日期:2018-11-01 00:00:00
abstract::Two alkaloids of the furoquinoline-type were isolated from Ammi majus L.; a new one and was identified as 4-hydro-7-hydroxy-8-methoxyfuroquinoline (1), and the other was isolated for the second time from nature and was identified as 4-hydro-7-hydroxy-8-prenyloxyfuroquinoline (2). The structures of the isolated compoun...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1217858
更新日期:2017-03-01 00:00:00
abstract::The use of natural products as a diet supplement is increasing worldwide but sometimes is not followed by adequate sanitary controls and analyses. Twenty samples of pills and capsules of lyophilised cyanobacteria (blue-green algae), commercialised in Italy as dietary supplements, were found positive at the Vibrio fisc...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410500410859
更新日期:2006-07-20 00:00:00
abstract::Artemisia herba-alba is widely used in traditional medicines for the treatment of several diseases. From the aerial parts organic extract of A. herba-alba, two new compounds, 1,3,8-trihydroxyeudesm-4-en-7α,11βH-12,6α-olide (1) and 5-β-D-glucopyranosyloxy-7-methoxy-6H-benzopyran-2-one (2), respectively, togethe...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1647430
更新日期:2019-07-31 00:00:00
abstract::The natural product lupeol 1 was isolated from aerial parts of Vernonia scorpioides with satisfactory yield, which made it viable to be used as starting material in semisynthetic approach. Ten lupeol derivatives 2-11 were prepared by classical procedures. Including, five new esters derivatives 7-11, which were obtaine...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1353982
更新日期:2018-02-01 00:00:00
abstract::Chemical investigation of the mycelial extract of a mixed culture of two marine alga-derived fungal strains of the genus Aspergillus has yielded one new cyclotripeptide, psychrophilin E (1), the recently reported oxepin-containing alkaloids, protuboxepin A (2) and oxepinamide E (3), together with three other polyketid...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.880911
更新日期:2014-01-01 00:00:00
abstract::Phytochemical investigations on Phyllanthus emblica have resulted in the isolation of the two new flavonoids, kaempferol-3-O-alpha-L-(6''-methyl)-rhamnopyranoside (1) and kaempferol-3-O-alpha-L-(6''-ethyl)-rhamnopyranoside (2). Their structures were determined on the basis of extensive spectroscopic studies including ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410601124664
更新日期:2007-07-20 00:00:00
abstract::Development of natural nano-based plant-protection formulations represents an emerging phenomenon that has been widely improved for crops protection and for enhancing the efficiency and safety of pesticides. In the present study we isolated the essential oil from the fruits of Citrus trifoliata L. and investigated it ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1675063
更新日期:2019-10-09 00:00:00
abstract::The chemical analyses of ethyl acetate-methanol (EtOAc-MeOH) extract of muricid gastropod mollusk, Chicoreus ramosus from the southeastern coast of Indian peninsular led to the identification of unprecedented cembrane-type diterpenoid, which was characterized as (3E, 6E, 10E)-8a-butoxy-17(15→14), 20(12→11)-bis-abeo-ce...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1527833
更新日期:2020-06-01 00:00:00
abstract::A phytochemical investigation of Ajuga forrestii Diels led to the isolation of 14 compounds, including eight neo-clerodane diterpenes (1-8), two phytoecdysteroids (9, 11), one stigmastane sterol (10) and three iridoid glycosides (12-14). The structures of these compounds were identified by spectroscopic methods and a ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1371161
更新日期:2018-04-01 00:00:00
abstract::The cholesteryl ester transfer protein (CETP), inhibition of which assists in maintaining a high level of high-density lipoprotein cholesterol in the blood, is a target for anti-atherosclerosis treatments. Orange monascus pigment was produced by a Monascus species in a 5 L jar fermenter and various derivative compound...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.905561
更新日期:2014-01-01 00:00:00
abstract::Thirteen phenones were obtained from the 70% ethanol extract of Paeonia suffruticosa Andrews. Their structures were determined on the basis of chemical methods and spectral data. Among them, compound 1 was identified as a new compound, and compounds 5 and 13 were obtained from genus Paeonia for the first time. The inh...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1230114
更新日期:2017-02-01 00:00:00
abstract::A new 1,4-phenanthraquinone was isolated from the roots of Menispermum dauricum. The structure was elucidated as 7-hydroxy-3,6-dimethoxy-1,4-phenanthraquinone on the basis of spectral evidence. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410310001620592
更新日期:2004-08-01 00:00:00
abstract::Phytochemical investigation on the stem bark of Shorea maxwelliana yielded five oligostilbenoids identified as α-viniferin (1), maximol A (2), vaticanol A (3), suffruticosol A (4) and vaticanol G (5). Chemotaxonomy of isolated compounds was discussed briefly. Major compounds were tested for neurotoxic and cytotoxic ac...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.730047
更新日期:2013-01-01 00:00:00
abstract::From the seed and leaf extracts of Eryngium species, two new compounds were isolated, along with an aliphatic ketone and several known terpenoids reported from a member of Umbelliferae for the first time. Their structures were elucidated by chemical methods and spectroscopic analysis. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701768303
更新日期:2010-03-01 00:00:00
abstract::The leaves of Alchornea floribunda and Alchornea cordifolia are used traditionally as topical anti-inflammatory agents. In this study, two highly lipophilic fractions AFLF and ACLF isolated from A. floribunda and A. cordifolia leaves respectively were investigated for topical anti-inflammatory effects using xylene-ind...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.512272
更新日期:2011-12-01 00:00:00
abstract::GC/FID and GC-MS analysis revealed germacrene D, bicyclogermacrene, α-cadinol and cubenol as major compounds from aril. Germacrene D, bicyclogermacrene, trans-caryophyllene and δ-elemene are major compounds in fruits. Germacrene D, spathulenol, trans-caryophyllene and caryophyllene oxide are major compounds in leaves....
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.987145
更新日期:2015-01-01 00:00:00
abstract::Two new and one known compounds were isolated from the methanol extract of Sesamum indicum leaves. By means of spectroscopic methods, their structures were elucidated and identified to be 3-epibartogenic acid (1), kaempferol 3-O-[2-O-(trans-p-coumaroyl)-3-O-α-L-rhamnopyranosyl]-β-D-glucopyranoside (2) and epigallocate...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1057730
更新日期:2016-01-01 00:00:00