Abstract:
:Chemical investigation of the mycelial extract of a mixed culture of two marine alga-derived fungal strains of the genus Aspergillus has yielded one new cyclotripeptide, psychrophilin E (1), the recently reported oxepin-containing alkaloids, protuboxepin A (2) and oxepinamide E (3), together with three other polyketide derivatives (4-6). The chemical structure and relative and absolute configurations of psychrophilin E (1) were unambiguously established based on HRMS, 1D, 2D NMR and chiral-phase HPLC analysis of its hydrolysate. All the isolated compounds were assessed for their anti-proliferative activity against four different human cancer cell lines and some of them revealed selective activities.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Ebada SS,Fischer T,Hamacher A,Du FY,Roth YO,Kassack MU,Wang BG,Roth EHdoi
10.1080/14786419.2014.880911subject
Has Abstractpub_date
2014-01-01 00:00:00pages
776-81issue
11eissn
1478-6419issn
1478-6427journal_volume
28pub_type
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