Antibiotic activity of Emerimicin IV isolated from Emericellopsis minima from Talcahuano Bay, Chile.

Abstract:

:Due to the increasing emergence of resistance of bacterial pathogens to current antibiotics, we have examined the marine fungi present in sea sediments obtained 200 m offshore to discover new antibacterial compounds active against multidrug-resistant bacteria. One strain, identified as Emericellopsis minima, was isolated from sediments of Talcahuano Bay (Chile). From the liquid culture of E. minima, we isolated Emerimicin IV, a unique fungal peptaibol that exhibited antibacterial activity. The structure of this compound was assigned by interpretation of 1H NMR and HR-LCMS data. Emerimicin IV showed bacteriostatic activity against clinical isolates of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis with MIC values ranging between 100 and 12.5 μg/mL.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Inostroza A,Lara L,Paz C,Perez A,Galleguillos F,Hernandez V,Becerra J,González-Rocha G,Silva M

doi

10.1080/14786419.2017.1344655

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

1361-1364

issue

11

eissn

1478-6419

issn

1478-6427

journal_volume

32

pub_type

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