Abstract:
:Due to the increasing emergence of resistance of bacterial pathogens to current antibiotics, we have examined the marine fungi present in sea sediments obtained 200 m offshore to discover new antibacterial compounds active against multidrug-resistant bacteria. One strain, identified as Emericellopsis minima, was isolated from sediments of Talcahuano Bay (Chile). From the liquid culture of E. minima, we isolated Emerimicin IV, a unique fungal peptaibol that exhibited antibacterial activity. The structure of this compound was assigned by interpretation of 1H NMR and HR-LCMS data. Emerimicin IV showed bacteriostatic activity against clinical isolates of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis with MIC values ranging between 100 and 12.5 μg/mL.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Inostroza A,Lara L,Paz C,Perez A,Galleguillos F,Hernandez V,Becerra J,González-Rocha G,Silva Mdoi
10.1080/14786419.2017.1344655subject
Has Abstractpub_date
2018-06-01 00:00:00pages
1361-1364issue
11eissn
1478-6419issn
1478-6427journal_volume
32pub_type
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