A new monoterpenoid indole alkaloid from Ochrosia elliptica.

Abstract:

:A new monoterpenoid indole alkaloid, 10-methoxyakuammidine (1), together with four known alkaloids (2-5), were isolated from the stems and leaves of Ochrosia elliptica. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. New compound 1 was evaluated for its cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. 1 exhibited inhibitory effects with IC50 values comparable to those of cisplatin.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Chen AH,Liu QL,Ma YL,Jiang ZH,Tang JY,Liu YP,Chen GY,Fu YH,Xu W

doi

10.1080/14786419.2016.1277349

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

1490-1494

issue

13

eissn

1478-6419

issn

1478-6427

journal_volume

31

pub_type

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