A rare diketopiperazine glycoside from marine-sourced Streptomyces sp. ZZ446.

Abstract:

:Two diketopiperazines were isolated from a culture of the marine-derived actinomycete Streptomyces sp. ZZ446. Their structures were elucidated as maculosin (1) and maculosin-O-α-L-rhamnopyranoside (2) based on their NMR and HRESIMS data, specific rotation, and chemical degradation. Maculosin-O-α-L-rhamnopyranoside (2) is a new diketopiperazine glycoside, a structural class not reported previously from the natural sources. Both compounds showed antimicrobial activity against methicillin-resistant Staphylococcus aureus, Escherichia coli, and Candida albicans with MIC values in a range from 26.0 to 37.0 μg/mL.[Formula: see text].

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Chen S,Zhang D,Chen M,Zhang Z,Lian XY

doi

10.1080/14786419.2018.1544978

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

1046-1050

issue

7

eissn

1478-6419

issn

1478-6427

journal_volume

34

pub_type

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