Abstract:
:Two diketopiperazines were isolated from a culture of the marine-derived actinomycete Streptomyces sp. ZZ446. Their structures were elucidated as maculosin (1) and maculosin-O-α-L-rhamnopyranoside (2) based on their NMR and HRESIMS data, specific rotation, and chemical degradation. Maculosin-O-α-L-rhamnopyranoside (2) is a new diketopiperazine glycoside, a structural class not reported previously from the natural sources. Both compounds showed antimicrobial activity against methicillin-resistant Staphylococcus aureus, Escherichia coli, and Candida albicans with MIC values in a range from 26.0 to 37.0 μg/mL.[Formula: see text].
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Chen S,Zhang D,Chen M,Zhang Z,Lian XYdoi
10.1080/14786419.2018.1544978subject
Has Abstractpub_date
2020-04-01 00:00:00pages
1046-1050issue
7eissn
1478-6419issn
1478-6427journal_volume
34pub_type
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