Abstract:
:Jatropha mutabilis (Pohl) Baill is an endemic species of the Caatinga biome, little studied in terms of chemical composition. The objective of this work was to develop an analytical methodology to quantify vitexin in the ethanolic extract of J. mutabilis and to evaluate the expectorant and antitussive activities in mice. The expectorant activity was performed by measuring the phenol red obtained from the bronchoalveolar fluid in animals and the antitussive activity was evaluated by the cough method induced by citric acid (0.4 M). The method developed by HPLC-DAD proved to be simple, linear, precise, accurate, robust and specific. Besides, both vitexin (0.2, 1 and 5 mg/kg) and the extract of J. mutabilis (20, 102, 510 mg/kg) showed efficacy in decrease cough and increase aqueous mucus in mice, but vitexin was more potent. Lastly, the identification of vitexin opens the possibility of new studies for J. mutabilis.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Costa EC,Menezes PMN,Silva FS,Ribeiro LAA,Rolim LA,Araújo ECDC,Nunes XPdoi
10.1080/14786419.2020.1837807subject
Has Abstractpub_date
2020-10-30 00:00:00pages
1-4eissn
1478-6419issn
1478-6427pub_type
杂志文章abstract::Plumieride (PLU), an iridoid isolated from Allamanda cathartica flowers, has been studied by our research group due to its anti-inflammatory potential, antidepressant-like and anxiolytic-like effects. This research investigated the involvement of GABAergic and monoaminergic systems in the anxiolytic-like effect elicit...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1737052
更新日期:2020-03-11 00:00:00
abstract::A new oleanolic-type triterpene glycoside, (3β,21β)-21-[(β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl)oxy]-3-hydroxyolean-12-en-28-oic acid (1), together with five analogues, oleanazuroside 1 (2), oleanazuroside 2 (3), 24-hydroxytormentic acid ester glucoside (4), 24-epi-pinfaensin (5), and oleanolic acid 3-O-α-l-arabi...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1258557
更新日期:2017-04-01 00:00:00
abstract::A new sesquiterpeniod, 6alpha, 7alpha, 10alpha-trihydroxyisoducane (1), together with two known sesquiterpenoids, oplodiol (2) and oplopanone (3), were isolated from the chloroform extract of the rhizomes of Homalomena occulta. Their structures were elucidated by 1D and 2D NMR spectral interpretation. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410802187817
更新日期:2009-01-01 00:00:00
abstract::A new isoflavone, 4'-prenyloxyvigvexin A (1) and a new pterocarpan, (6aR,11aR)-3,8-dimethoxybitucarpin B (2) were isolated from the leaves of Lonchocarpus bussei and the stem bark of Lonchocarpus eriocalyx, respectively. The extract of L. bussei also gave four known isoflavones, maximaisoflavone H, 7,2'-dimethoxy-3',4...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1462179
更新日期:2019-09-01 00:00:00
abstract::A new β-hydroxydihydrochalcone glycoside named ziganin (1) and a new acylated flavonol glycoside named isorhamnetin-3-O-α-L-(2″,3″-di-O-trans-coumaroyl)-rhamnopyranoside) (2), along with two known flavonoid glycosides, a β-hydroxydihydrochalcone glycoside, a hydroxybenzoic acid derivative, a trinorguaiane type sesquit...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1062006
更新日期:2016-01-01 00:00:00
abstract::Five flavonoids were isolated from the ethyl acetate fraction of leaves of Sophora secundiflora; formononetin (1), 5-hydroxy-4'-methoxyflavone (2), genistein (3), 5-hydroxy-8-(1-hydroxy-1-methyl-ethyl)-2-(4-hydroxyphenyl)-4H-furo-[2, 3-h]-chromen-4-one (4) and ononin (5). Additionally, LC-ESI-MS/MS analysis of the eth...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1795853
更新日期:2020-07-22 00:00:00
abstract::The aim of this work was to provide a characterisation of volatile constituents from different commercial batches of henna (Lawsonia inermis) leaves of different geographic origin. Headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS) was used for the purpose. A tota...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1055491
更新日期:2016-01-01 00:00:00
abstract::Tryptamine derivatives such as tryptamine and bacillamides were strong algicidal compounds promising in controlling harmful algae blooms, but their bioactivity and application researches were hindered by extremely low natural production rates. This study found an induced production of algicidal tryptamine derivatives ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1005619
更新日期:2015-01-01 00:00:00
abstract::A new protein detector of 2,4,6-trinitrophenol (TNP, picric acid) is concisely reported herein for the first time. In brief, the gene of a specific scFv fragment, namely 3.5, was fused separately with the gene of β-lactamase and, subsequently, expressed in the periplasmic space of Escherichia coli, affording in such a...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1860977
更新日期:2020-12-18 00:00:00
abstract::The importance of the present study is to find out the phytochemical profile of essential oil (EO) of Artemisia tournefortiana Reichb. and its biological evaluation. Nineteen volatile constituents were identified from EO representing 93.47% of total oil composition. Oxygenated monoterpenes (54.46%) were found to be do...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1613990
更新日期:2021-01-01 00:00:00
abstract::This study was designed to characterise the effects of evodiamine on intestinal contractility and reveal the correlated mechanisms. Evodiamine (2.5-80.0 μM) increased normal jejunal contractility and jejunal hypocontractility established under a variety of experimental conditions. Evodiamine-exerted stimulatory effect...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.947485
更新日期:2015-01-01 00:00:00
abstract::Two new eremophilenolides, ligushicins A (1) and B (2), and two known compounds including β-sitosterol and ursolic acid were isolated from Ligulariopsis shichuana. The structures of new compounds were established on the basis of 1D and 2D NMR data and HRESIMS data interpretation. The absolute configuration of new comp...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1419240
更新日期:2019-05-01 00:00:00
abstract::A new flavonoid, dihydroglychalcone-A, was isolated from the leaves extract of Glycosmis chlorosperma in addition to two known sulphur-containing amides, dambullin and gerambullin. The structure of the new compound was assigned as 2'-hydroxy-4,6'-dimethoxy-3',4'-(2",2"-dimethylpyrano)dihydrochalcone. The extract of th...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/1057563031000122121
更新日期:2004-02-01 00:00:00
abstract::The essential oil of Cyclospermum leptophyllum (Pers.) Sprague ex Britton and P. Wilson syn. Apium leptophyllum (Pers.) F. Muell. Ex Benth., family Apiaceae (Umbellifereae), was analysed by GC and GC-MS. The essential oil showed the presence of thymohydroquinone dimethyl ether (50.7%), thymol methyl ether (11.2%), γ-t...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.487190
更新日期:2011-03-01 00:00:00
abstract::In Brazilian folk medicine, Protium heptaphyllum is used to treat inflammatory conditions and to hasten wound repair. This paper aims to investigate the chemical composition and the in vitro antibacterial effects of the essential oils (EOs) obtained from P. heptaphyllum leaves and ripe and unripe fruits against a repr...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1536659
更新日期:2020-08-01 00:00:00
abstract::The antiradical activity of the freshwater bryozoan Hyalinella punctata water extracts (two samples, seasonal collection) was evaluated by using electron paramagnetic resonance spectroscopy against hydroxyl (√OH), superoxide anion (√O2(- )), methoxy (√CH2OH), carbon-dioxide anion (√CO2(- )), nitric-oxide (√NO) and 2,2...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.921788
更新日期:2014-01-01 00:00:00
abstract::A new highly oxygenated germacranolide, carcerlane A (1), together with four known highly oxygenated germacranolides (2-5), was isolated from an ethanol extract of the whole plant of Carpesium nepalense var. lanatum (C.B.Clarke) Kitam. The structures were determined by HRESIMS and extensive analysis of their spectrosc...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1833199
更新日期:2020-10-22 00:00:00
abstract::A new triterpene, javablumine A (1) along with six known ones were isolated from the aerial parts of Sambucus javanica Blume. They were identified as 3β,23-dihydroxy-11α,12α-epoxy-urs-20(30)-en-28,13β-olide (1), ursolic acid (2), pomolic acid (3), oleanic acid (4), 2α-hydroxy-oleanolic acid (5), α-amyrin (6), and lupe...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1596092
更新日期:2020-10-01 00:00:00
abstract::Moringa oleifera Lam. family Moringaceae is well known for a wide range of biological activities and a complex phytochemical composition. The current study investigates tissue culture protocols for Moringa oleifera leaves and seeds. For static culture initiation, Murashige and skooge (MS) as a basal medium with hormon...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1744137
更新日期:2020-03-25 00:00:00
abstract::A new triterpenic glucoside, lup-1,5,20(29)-trien-3-O-beta-D-glucopyranoside (4), along with three known phytoconstituents: n-octacosane, friedelin and beta-amyrin, has been isolated from the leaves of Clerodendrum inerme (L.) Gaertn. (Verbenaceae). Structure elucidation was carried out on the basis of chemical and ph...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410902975566
更新日期:2010-01-01 00:00:00
abstract::In this study, Box-Behnken Design was used to optimize the ultrasonic extraction of polysaccharides from quince peels (QPPs) by ascorbic acid and the effect of extraction temperature, extraction time and pH was evaluated. Under optimized conditions of temperature 90 °C, 60 min sonication time and pH = 3.26, the extrac...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1514403
更新日期:2020-05-01 00:00:00
abstract::A new rare lumazine peptide, penilumamide E (1), together with 13 known compounds (2-14) were isolated from the fungus Aspergillus terreus. Their structures were identified by spectroscopic techniques. The relative configuration of 1 was confirmed by single-crystal X-ray diffraction analysis. Compound 10 exhibited ant...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1101107
更新日期:2016-01-01 00:00:00
abstract::In the present study, profiles of fatty acid, sn-2 fatty acid, triglyceride, phytochemical (including tocopherol/tocotrienol, phytosterol, flavonoid, carotenoid and polyphenol) and antioxidant capacity of extracts from the whole berry, pulp and seed of Hippophae¨ rhamnoides ssp. yunnanensis were investigated and compa...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1488703
更新日期:2019-12-01 00:00:00
abstract::The microbial transformation of androst-4-ene-3,17-dione (4-AD; I) by three fungal species, involved Fusarium solani BH1031, Aspergillus awamori MH18 and Mucor circinelloides W12, has been studied. The latter two fungi were studied for the first time on biotransformation of 4-AD. The main product obtained by Fusarium ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1636238
更新日期:2021-02-01 00:00:00
abstract::In this investigation, the effect of Matricaria chamomilla extract on linear incisional wound healing was studied. Thirty male Wistar rats were subjected to a linear 3 cm incision made over the skin of the back. The animals were randomly divided into three experimental groups, as control, olive oil, and treatment. Con...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701654875
更新日期:2010-05-01 00:00:00
abstract::Fermentation of (+)-androst-4-ene-3,17-dione (1) with Curvularia lunata for 10 days yielded five oxidative and reductive metabolites, androsta-1,4-diene-3,17-dione (2), 17beta-hydroxyandrosta-1,4-dien-3-one (3), 11alpha-hydroxyandrost-4-ene-3,17-dione (4), 11alpha,17beta-dihydroxyandrost-4-en-3-one (5) and 15alpha-hyd...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410310001620628
更新日期:2004-12-01 00:00:00
abstract::The purpose of this study is to identify the quantity and antibacterial activity of the individual phenolic compounds in Brazilian red propolis. Quantitative analysis of the 12 phenolic compounds in Brazilian red propolis was carried out using reversed-phase high-performance liquid chromatography. The main phenolic co...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.898146
更新日期:2014-01-01 00:00:00
abstract::Diphysidione (1), a new p-hydroxyphenyl anhydride, and vitexin (2) were isolated from the leaves of Diphysa carthagenensis. The structure of the new metabolite was characterised as 4-(4-hydroxy-phenyl)-3H-pyran-2,6-dione using 1D and 2D NMR spectroscopy. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.668689
更新日期:2013-01-01 00:00:00
abstract::One new sesqui-neolignan compound, namely, sesqui-illisimonan A (1), one new neolignan, illisimonan A (2), and one new phenylpropanoid compound, illisimoid A (3) were isolated from the fruits of Illicium simonsii Maxim. The structures and absolute configurations of these compounds were determined by extensive spectros...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1422179
更新日期:2018-10-01 00:00:00
abstract::Specimens of the cosmopolitan sea hare Aplysia parvula, collected in the Tsistsikamma National Park on the south-east coast of South Africa yielded the new dibromo-C15-acetogenin, (3Z)-bromofucin (1). Standard spectroscopic methods were used to establish the structure of this compound. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410412331271960
更新日期:2005-07-01 00:00:00