Abstract:
:A new rare lumazine peptide, penilumamide E (1), together with 13 known compounds (2-14) were isolated from the fungus Aspergillus terreus. Their structures were identified by spectroscopic techniques. The relative configuration of 1 was confirmed by single-crystal X-ray diffraction analysis. Compound 10 exhibited antimalarial activity against Plasmodium falciparum with IC50 values of 2.83 μg/mL. Compounds 4 and 6 showed weak cytotoxicity against cholangiocarcinoma (CCA) cell lines. In addition, 4 and 11 exhibited weak cytotoxicity against human hepatoma cell line.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Chaiyosang B,Kanokmedhakul K,Boonmak J,Youngme S,Kukongviriyapan V,Soytong K,Kanokmedhakul Sdoi
10.1080/14786419.2015.1101107subject
Has Abstractpub_date
2016-01-01 00:00:00pages
1017-24issue
9eissn
1478-6419issn
1478-6427journal_volume
30pub_type
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