A new lumazine peptide penilumamide E from the fungus Aspergillus terreus.


:A new rare lumazine peptide, penilumamide E (1), together with 13 known compounds (2-14) were isolated from the fungus Aspergillus terreus. Their structures were identified by spectroscopic techniques. The relative configuration of 1 was confirmed by single-crystal X-ray diffraction analysis. Compound 10 exhibited antimalarial activity against Plasmodium falciparum with IC50 values of 2.83 μg/mL. Compounds 4 and 6 showed weak cytotoxicity against cholangiocarcinoma (CCA) cell lines. In addition, 4 and 11 exhibited weak cytotoxicity against human hepatoma cell line.


Nat Prod Res


Natural product research


Chaiyosang B,Kanokmedhakul K,Boonmak J,Youngme S,Kukongviriyapan V,Soytong K,Kanokmedhakul S




Has Abstract


2016-01-01 00:00:00












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    abstract::In the course of our efforts to search new secondary metabolites from marine-derived fungi, one new hexylitaconic acid derivative, 3-(5-methoxycarbonylpentyl)-4-methylfuran-2,5-dione (1), and two dimeric analogues asperwelwinates A and B (2 and 3), together with ten known compounds, asperitaconic acid C (4), kotanin (...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Han J,Yang N,Wei S,Jia J,Lin R,Li J,Bi H,Song F,Xu X

    更新日期:2020-07-15 00:00:00

  • Three new 3-benzylbenzofuran-2-one derivatives from Homalium brachybotrys (Flacourtiaceae/Salicaceae s. l.).

    abstract::Eight phenolic compounds, including two mixtures of two compounds, were isolated from the ethyl acetate extract of leaves and stems of Homalium brachybotrys. They were identified on the basis of spectroscopic data as quercetin-3-O-beta-glucopyranoside, luteolin-7-O-beta-glucopyranoside, 5,6-dihydro-6-beta-glucopyranos...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Mosaddik A,Forster PI,Waterman PG

    更新日期:2007-11-01 00:00:00

  • Effect of meteorological parameters and regions on accumulation pattern of phenolic compounds in different mulberry cultivars grown in China.

    abstract::The compositions of phenolic compounds in 10 cultivars of two mulberry species (Morus atropurpurea Roxb. and Morus alba Linn.) grown in four regions of China were analysed using HPLC-TOF-MS. Results showed that a total of 27 phenolic compounds were identified in these mulberry cultivars. The Taiwan cultivar from the J...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Yang J,Zhang X,Jin Q,Gu L,Liu X,Li J,Ni Y

    更新日期:2017-05-01 00:00:00

  • A new macrocyclic diterpenoid from Jatropha multifida.

    abstract::A new diterpenoid, 15-epi-(4E)-jatrogrossidentadione acetate, along with several known constituents has been isolated from the stem of Jatropha multifida. The structure of the new compound was settled by a detailed analysis of its 1D- and 2D-NMR spectra. ...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Das B,Satya Kumar A,Narayan Kumar J,Venugopal Raju T

    更新日期:2010-10-01 00:00:00

  • Identification of a cDNA clone specific for the taxol synthesis phase of Taxus chinensis cells by mRNA differential display.

    abstract::In order to identify genes related to Taxol biosynthesis, the mRNA differential display method was employed to compare mRNA populations from suspension cultured Taxus chinensis cells before and after beginning to produce Taxol. From a total display of about 4000 PCR products, 104 were derived from cells during the Tax...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Hu G,Fan T,Mei X

    更新日期:2004-08-01 00:00:00

  • New antidepressant drug candidate: Hypericum montbretti extract.

    abstract::This study was designed to investigate possible antidepressant-like effects of the extract prepared from the flowers of Hypericum montbretti Spach. (Guttiferae, Clusiaceae). Phytochemical constituents of the methanolic extract were analysed by HPLC method. The main flavonoid component was detected as rutin, and anothe...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Can OD,Ismail IB,Oztürk Y,Oztürk N,Potoğlu-Erkara I,Sagratini G,Ricciutelli M,Vittori S,Maggi F

    更新日期:2011-09-01 00:00:00

  • Schizonticidal antimalarial sesquiterpene lactones from Magnolia champaca (L.) Baill. ex Pierre: microwave-assisted extraction, HPTLC fingerprinting and computational studies.

    abstract::The present study explored the schizonticidal potential of traditionally used Magnolia champaca (L.) Baill. ex. Pierre flowers, identifying constituents of interest. The extraction of phytoconstituents was carried out by microwave-assisted technique, isolated via column chromatography, and characterised by various phy...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Mehrotra E,Vishwakarma J,Tripathi AC,Sonar PK,Saraf SK

    更新日期:2019-02-01 00:00:00

  • Insecticidal and α-glucosidase inhibitory activities of chemical constituents from Viburnum fordiae Hance.

    abstract::The ethanolic extract of the stems of Viburnum fordiae Hance showed insecticidal and α-glucosidase inhibitory activities and then was fractionated by bioactivity-guided fractionation to obtain a rare C13-norisoprenoid (1), together with a new phenolic glycoside (2), and seven known compounds, alangionoside C (3), pisu...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Shao JH,Chen J,Zhao CC,Shen J,Liu WY,Gu WY,Li KH

    更新日期:2019-09-01 00:00:00

  • Chemical constituents of Geum urbanum L. roots.

    abstract::A new dehydrodigallic acid derivative (1), along with 19 known compounds, including 6 phenolic derivatives, 2 steroids and 11 triterpenoids were isolated from the ethanol extract of the root of Geum urbanum. Herein, there is the first report of steroid and triterpene in Geum urbanum. The purified metabolites were char...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Ton That Q,Nguyen Thien TV,Dang HP,Le Hoan N,Vo LKT,Nguyen MHD,Ngu NT,Nguyen TS,Hansen PE

    更新日期:2018-11-01 00:00:00

  • Discovery of potent and selective acetylcholinesterase (AChE) inhibitors: acacetin 7-O-methyl ether Mannich base derivatives synthesised from easy access natural product naringin.

    abstract::Naringin, as a component universal existing in the peel of some fruits or medicinal plants, was usually selected as the material to synthesise bioactive derivates since it was easy to gain with low cost. In present investigation, eight new acacetin-7-O-methyl ether Mannich base derivatives (1-8) were synthesised from ...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Liu HR,Men X,Gao XH,Liu LB,Fan HQ,Xia XH,Wang QA

    更新日期:2018-03-01 00:00:00

  • A new β-tetralonyl glucoside from the Santalum album derived endophytic fungus Colletotrichum sp. GDMU-1.

    abstract::A new β-tetralonyl glucoside, methylberchemiaside (1), along with five known compounds (2-6) were isolated from a fungus Colletotrichum sp . GDMU-1 derived from the leaves of Santalum album. Their structures were determined by detailed analysis of spectroscopic data. All compounds were tested for the inhibitory effect...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Liu W,Chen S,Li J,Yang X,Yan C,Liu H

    更新日期:2019-02-01 00:00:00

  • Analgesic and anti-inflammatory properties of Thespesia populnea leaf extracts.

    abstract::Analgesic and anti-inflammatory activities of the aqueous and ethanol extracts of Thespesia populnea Soland. ex. Correa (Malvaceae) leaves were evaluated in animal models. Orally-administered aqueous and ethanol extracts (100, 200 and 400 mg kg⁻¹ bw) showed significant analgesic activity in chemical-, mechanical- and ...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Ilavarasan R,Mohideen S,Venkataraman S

    更新日期:2012-01-01 00:00:00

  • Antiproliferative activity and chemical constituents of Lonchocarpus cultratus (Fabaceae).

    abstract::The aerial parts of L. cultratus were submitted to a phytopharmacological investigation in order to isolate and identify the major secondary metabolites and evaluate its crude extract, fractions and isolated compounds for antiproliferative activity. Seven compounds were isolated and identified as the chalcones 2',4'-d...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: da Silva Landim EMBM,Ruiz ALTG,de Carvalho JE,Pomini AM,Pastorini LH,Oliveira Santin SM

    更新日期:2019-08-12 00:00:00

  • Maydisone, a novel oxime polyketide from the cultures of Bipolaris maydis.

    abstract::A novel oxime polyketide, maydisone (1), along with two known compounds, 7-hydroxy-2,5-dimethylchromone (2) and 2,5-dimethylbenzoic acid (3) were isolated from the cultures of Bipolaris maydis. Their structures were identified by the application of NMR and MS data analyses and comparison with previous reports. Compoun...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Tran TM,Nguyen VK,Duong TH,Tran TN,Nguyen NH,Devi AP,Chavasiri W,Dinh MH,Tran NM,Sichaem J

    更新日期:2020-05-13 00:00:00

  • Comparison of antioxidant, anticholinesterase, and antidiabetic activities of three curcuminoids isolated from Curcuma longa L.

    abstract::Antioxidant, anticholinesterase and antidiabetic activities of three curcuminoids isolated from the Curcuma longa were simultaneously tested and compared in this study. The highest antioxidant power was detected for curcumin with the applied methods. The drug potentials of curcuminoids for Alzheimer's disease were con...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Kalaycıoğlu Z,Gazioğlu I,Erim FB

    更新日期:2017-12-01 00:00:00

  • A new squalene derivative from Physalis angulata L. (Solanaceae).

    abstract::Physalis angulata is an annual herb which has tremendous medicinal uses. The antioxidant activity of the whole plant extract of Physalis angulata was investigated using DPPH radical scavenging activity. Purified compounds were isolated using column chromatography method. Their structures were determined using various ...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Odusina BO,Onocha PA

    更新日期:2020-11-23 00:00:00

  • A new trans-neoclerodane diterpene from Stachys aegyptiaca.

    abstract::Phytochemical investigation of the methylenechloride/methanol extract of the aerial parts of Stachys aegyptiaca afforded a new neoclerodane-type diterpene with a new side chain 1, in addition to two known diterpenes 2 and 3 and a known flavonoid glycoside 4. The structures of the compounds were determined by comprehen...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Mohamed Ael-H,Mohamed NS

    更新日期:2014-01-01 00:00:00

  • In vitro anti-enteroviral activity of stilbenoids isolated from the leaves of Macaranga barteri.

    abstract::The anti-enteroviral activity of three stilbenoids isolated from the leaves of Macaranga barteri was investigated using the cytopathic effect reduction assay. The stilbenes were inactive against echovirus E13 but showed activity against echoviruses E7 and E19. In particular, vedelianin (2), schweinfurthin G (3) and ma...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Segun PA,Ogbole OO,Akinleye TE,Faleye TOC,Adeniji AJ

    更新日期:2019-07-25 00:00:00

  • Lavandin (Lavandula × intermedia Emeric ex Loiseleur) essential oil from Spain: determination of aromatic profile by gas chromatography-mass spectrometry, antioxidant and lipoxygenase inhibitory bioactivities.

    abstract::Lavandin (Lavandula × intermedia Emeric ex Loiseleur) essential oils (EOs), from Abrial, Super and Grosso cultivars, cultivated and extracted in the South East of Spain, were analysed by using GC/MS to determine their composition, in both relative (peak area) and absolute (using standard curves) concentrations. Linalo...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Carrasco A,Martinez-Gutierrez R,Tomas V,Tudela J

    更新日期:2016-01-01 00:00:00

  • Anti-proliferative and pro-apoptotic effects of cinobufagin on human breast cancer MCF-7 cells and its molecular mechanism.

    abstract::Cinobufagin (CBF) is an active ingredient isolated from Venenum Bufonis extracted and dried from the secretory glands of Bufo gargarizans Cantor. The purpose of the study was to investigate the effects and underlying mechanisms of CBF on human breast cancer MCF-7 cells in vitro. Our results showed that CBF exhibited o...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Zhu L,Chen Y,Wei C,Yang X,Cheng J,Yang Z,Chen C,Ji Z

    更新日期:2018-02-01 00:00:00

  • Purification and characterization of two grandiuvarones from Desmos chinensis leaves and their antimicrobial activities.

    abstract::A novel aromatic compound, grandiuvarone B (5-acetoxy-3-benzoyloxymethyl-5H-oxepin-4-one), along with a known compound grandiuvarone A (5-acetoxy-6-benzoyloxymethyl-5H-oxepin-4-one) were isolated from methanol extracts of Desmos chinensis leaves. Their structures were determined by various spectroscopic techniques inc...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Zhi QQ,Yan QH,Wang Q,Sun PF,Zhou HY,He ZM

    更新日期:2020-04-01 00:00:00

  • Semi-preparative HPLC purification of δ-tocotrienol (δ-T3) from Elaeis guineensis Jacq. and Bixa orellana L. and evaluation of its in vitro anticancer activity in human A375 melanoma cells.

    abstract::In this work, we report a rapid and convenient HPLC-UV-DAD method for the isolation of δ-T3 on semi-preparative scale from two different vitamin E rich processed, commercially available products obtained from the fruits of Elaeis guineensis Jacq. (oil palm) and from the seeds of Bixa orellana L. (achiote tree). Chroma...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Beretta G,Gelmini F,Fontana F,Moretti RM,Montagnani Marelli M,Limonta P

    更新日期:2018-05-01 00:00:00

  • Influence of extraction solvent on antioxidant capacity value of oleaster measured by ORAC method.

    abstract::Oxygen radical absorbance capacity (ORAC) is a widely used hydrogen atom transfer-based method which measures the antioxidant capacity of natural products. ORAC values of oleaster (Elaeagnus angustifolia L.), which was extracted with ethanol/acetone (7:3, v/v), ethanol/water (1:1, v/v) and methanol/water (1:1, v/v) in...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Yalcin G,Sogut O

    更新日期:2014-01-01 00:00:00

  • Glaucocalyxin A: a review.

    abstract::Glaucocalyxin A is a natural ent-Kaurane diterpenoid. It has been widely studied for some important biological activities like cytotoxicity and anti-tumour, anti-bacterial, anti-oxidative, anti-coagulative, anti-thrombotic, immune and anti-neuroinflammatory activities. The aim of the present article is to review the a...

    journal_title:Natural product research

    pub_type: 杂志文章,评审


    authors: Xiang Z,Wu X,Liu X,Jin Y

    更新日期:2014-01-01 00:00:00

  • Volatile constituents of Origanum vulgare L., 'thymol' chemotype: variability in North India during plant ontogeny.

    abstract::Essential oils derived from six different phenophases, namely early vegetative stage, late vegetative stage, early flowering stage, full flowering stage (FFS), late flowering stage and seed shattering stage of Origanum vulgare L. grown in Kumaon region of Uttarakhand, India were investigated by GC and GC-MS. A total o...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Verma RS,Padalia RC,Chauhan A

    更新日期:2012-01-01 00:00:00

  • Cochliomycin G, a 14-membered resorcylic acid lactone from a marine-derived fungus Cochliobolus lunatus.

    abstract::Cochliomycin G (1), a new 14-membered resorcylic acid lactone, together with six known analogues (2-7), was isolated from the culture broth of a marine-derived fungus Cochliobolus lunatus. The planar structure of 1 was established by extensive NMR spectroscopy, and the absolute configuration was elucidated by the comb...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Xu WF,Xue XJ,Qi YX,Wu NN,Wang CY,Shao CL

    更新日期:2021-02-01 00:00:00

  • 2,4,5-Tribromo-1H-imidazole in the egg masses of three muricid molluscs.

    abstract::From analysis by gas chromatography/mass spectrometry (GC/MS), the presence of either 2,4,5-tribromo-1H-imidazole (1) or 3,4,5-tribromo-1H-pyrazole (2) was tentatively identified in lipophilic extracts from the egg masses of three muricid molluscs. Synthesis of these compounds, followed by comparison of the GC retenti...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Benkendorff K,Pillai R,Bremner JB

    更新日期:2004-10-01 00:00:00

  • Penixanthones A and B, two new xanthone derivatives from fungus Penicillium sp. SYFz-1 derived of mangrove soil sample.

    abstract::Two new xanthone derivatives, penixanthones A (1) and B (2), together with three known compounds, aspenicillide (3), 1,5-dihydroxy-3-methoxy-7-methyl-anthracene-9,10-dione (4) and 1,2-indandiol (5), were isolated from the ethyl acetate extract of a culture of the fungus Penicillium sp. SYFz-1, which was separated from...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Tao H,Wei X,Lin X,Zhou X,Dong J,Yang B

    更新日期:2017-10-01 00:00:00

  • A new furan derivative from an endophytic Aspergillus tubingensis of Decaisnea insignis (Griff.) Hook.f. & Thomson.

    abstract::A new furan derivative named 3-(5-oxo-2,5-dihydrofuran-3-yl) propanoic acid (1) was isolated for the first time. Its structure was elucidated by UV, IR, NMR, HR-ESI-MS and the single-crystal X-ray diffraction spectroscopic data. Meanwhile, the antifungal and antibacterial activities of compound 1 was tested, it exhibi...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Yang XF,Wang NN,Kang YF,Ma YM

    更新日期:2019-10-01 00:00:00

  • Evaluation of the antioxidant and anti-inflammatory activities of solvent extracts of Tricholepis chaetolepis (Boiss) Rech. f. whole plant.

    abstract::The whole plant, Tricholepis chaetolepis, powder was investigated using proximate and fluorescence analysis along with determining the extractive values. Total phenolics, flavonoids and total protein contents of n-hexane, chloroform and methanolic extracts of the whole plant were also determined. The anti-diabetic act...

    journal_title:Natural product research

    pub_type: 杂志文章


    authors: Abbas A,Hassan SS,Sharif A,Ahmed S

    更新日期:2020-02-01 00:00:00