A new lumazine peptide penilumamide E from the fungus Aspergillus terreus.

Abstract:

:A new rare lumazine peptide, penilumamide E (1), together with 13 known compounds (2-14) were isolated from the fungus Aspergillus terreus. Their structures were identified by spectroscopic techniques. The relative configuration of 1 was confirmed by single-crystal X-ray diffraction analysis. Compound 10 exhibited antimalarial activity against Plasmodium falciparum with IC50 values of 2.83 μg/mL. Compounds 4 and 6 showed weak cytotoxicity against cholangiocarcinoma (CCA) cell lines. In addition, 4 and 11 exhibited weak cytotoxicity against human hepatoma cell line.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Chaiyosang B,Kanokmedhakul K,Boonmak J,Youngme S,Kukongviriyapan V,Soytong K,Kanokmedhakul S

doi

10.1080/14786419.2015.1101107

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

1017-24

issue

9

eissn

1478-6419

issn

1478-6427

journal_volume

30

pub_type

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