Abstract:
:Three allylbenzenes from Asiasarum heterotropoides, methyleugenol (1), elemicin (2) and gamma-asaron (3) showed suppressive effects on umu gene expression of the SOS response in the Salmonella typhimurium OY1001/1A2 umu test against the mutagen 2-amino-3,4-dimethylimidazo[4,5-f ]quinoline (MeIQ). Gene expression was suppressed 70.0, 75.9 and 81.7% at a concentration of 0.4 mM, respectively. The ID50 values (50% inhibition dose) of these compounds were 0.125, 0.098 and 0.059 mM, respectively. On the other hand, compounds 1-3 showed weak suppressive effects of the SOS-inducing activity on activated MeIQ.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Miyazawa M,Kohno G,Okuno Y,Oda Ydoi
10.1080/14786410500462629subject
Has Abstractpub_date
2006-06-01 00:00:00pages
671-5issue
7eissn
1478-6419issn
1478-6427pii
P116853V17Q71126journal_volume
20pub_type
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