Abstract:
:The aerial portions of Cynara scolymus commonly have been eaten as vegetables or functional foods by the people lived in Mediterranean region. In preliminary antioxidant screening, the rhizome portions (CSR) of this species showed better potential than leaves ones. However, neither phytochemical nor pharmacology studies of CSR have been reported to date. The purpose of this research was to identify the active components from CSR through bioassay-guided fractionation. The antioxidant properties of secondary metabolites 1-9 were evaluated in this investigation. Compounds 4-6, 8, and 9 showed antioxidant activities based on DPPH free radical scavenging activity with IC50 values of 22.91-147.21 μM. Besides, compound 8 significantly and dose-dependently reduced H2O2-induced ROS levels in keratinocyte HaCaT cells without cytotoxicity toward HaCaT. Overall, our studies demonstrated the rhizome of C. scolymus could be used as a new natural antioxidant like the edible aerial portions and phenolic compounds are the active components.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Lee CL,Liao KC,Chen CC,Lin YA,Wu TY,Jhan YL,Chen CJ,Yang JC,Wu YCdoi
10.1080/14786419.2019.1645664subject
Has Abstractpub_date
2019-07-30 00:00:00pages
1-5eissn
1478-6419issn
1478-6427pub_type
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