Abstract:
:ABTRACT This study aims to design and synthesize a series of N-Acyl-N-(m-fluoro- benzyl)-6- amino-coumarins through the principle of active substructure stitching, which are based on the core structure of N-(m-fluoro-benzyl)-6-amino-coumarin. The structures of target compounds e1-e25 have been characterized by 1H NMR, 13C NMR, ESI-MS and elemental analysis. Meanwhile, their agricultural activity have been evaluated in two weeds (Amaranth and Crabgrass) and four widespread noxious pathogens (V.mali, B.cinerea, F.axysporium and C.bacteria). The herbicidal activity results showed that almost all synthetic molecules have a greater impact on the stem system than on the root. Excellent inhibition rates were discovered from compounds e2-e5 and e20-e23 against Amaranth on stems, which were above 58%(20 mg/L), 68%(100 mg/L) respectively. Compounds e2 and e21 also exhibited striking inhibition on stems growth of both weeds. Anti-pathogenic activity showed that all the compounds exerted a better inhibitory activity on B.cinerea at 20 ppm compared to control carbendazim. All the heterocyclic substituted compounds (e17-e24, >57%) made a better influence than the control (54.1%) at the100 ppm. This research provides promising herbicidal and anti-pathogenic agents that have the better effects and can be potential for further development.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Jin Y,Ding YH,Dong JJ,Wei Y,Hao SH,Feng BCdoi
10.1080/14786419.2020.1806268subject
Has Abstractpub_date
2020-08-13 00:00:00pages
1-7eissn
1478-6419issn
1478-6427pub_type
杂志文章abstract::A new and efficient synthesis of a naturally occurring amide alkaloid, N-isobutyl-4,5-epoxy-2(E)-decenamide isolated from the roots of Piper nigrum has been described involving a total of nine steps. Octanal and 2-bromoacetic acid have been used as the starting materials. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.678349
更新日期:2013-01-01 00:00:00
abstract::Four C-13, C-14 side chain modified 9(R)-hydroxy-1-deoxy-taxane analogues 15, 16, 19 and 22 were semi-synthesized from 1-deoxybaccatin VI. The in vitro antitumor activity of these compounds was evaluated against A549 and A2780 cell lines. The preliminary SAR analysis showed that introduction of oxygen-containing group...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1484459
更新日期:2019-12-01 00:00:00
abstract::To date, despite extensive investigations, full understanding of the endocannabinoid system remains elusive; in particular, anandamide cellular uptake is a current controversial topic. An iodo-arylazido probe was synthesized from commercially available azelaic acid monomethyl ester, in order to shed light on the anand...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410500057015
更新日期:2005-06-01 00:00:00
abstract::Illicium lanceolatum is a popular aromatic and medicinal plant in China. Essential oil from the roots of I. lanceolatum, obtained by hydrodistillation, was analysed by GC-MS. The essential oil was dominated by phenylpropenes. The major components were myristicin (17.63%), α-asarone (17.23%), methyl isoeugenol (11.19%)...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.603318
更新日期:2012-01-01 00:00:00
abstract::The emphasis of the present study is to evaluate a natural product and the potential microbicide activity using a dual chamber infection method. Malva sylvestris extracts and fractions were screened for anti-HIV activity by measuring the virus-antibody neutralization. Plant extracts with strong antiviral activity work...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1619720
更新日期:2019-08-20 00:00:00
abstract::Flavonoids have always attracted much attention due to their reversal activity on multidrug resistance (MDR). Eight flavonoids isolated from traditional Chinese medicine Sophora alopecuroides L. were applied to test their effect on MDR associated protein 1 (MRP1) through the established predicting assay. Three flavono...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.930856
更新日期:2014-01-01 00:00:00
abstract::Juniperus chinensis cv. Kaizuca has extensive pharmacological activities. The cone oils exhibited protein tyrosine phosphatase 1B inhibitory activity in vitro. The IC50 value was 4.49 ± 0.04 μg/mL. A total of 17 compounds were characterised from the cone oils by GC-MS. In order to explain the activity against protein ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1374267
更新日期:2018-11-01 00:00:00
abstract::The present work describes the metabolites produced by a strain identified as Streptomyces youssoufiensis, whose secondary metabolites profile has not been studied so far. The crude ethyl acetate extract was analyzed by high performance liquid chromatography-electrospray ionization mass spectrometry, leading to the de...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1446014
更新日期:2019-01-01 00:00:00
abstract::The chemical composition of the essential oil (EO) obtained from the aerial parts of Rydingia michauxii (Briq.) Scheen & V.A. Albert was analysed by gas chromatography and gas chromatography/mass spectrometry (GC/MS). Eighty components were identified in the oil with caryophyllene oxide (20.1%), trans-verbenol (10.2%)...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1343321
更新日期:2018-01-01 00:00:00
abstract::The search for bioactive natural products from the rhizomes of Paris polyphylla (Trilliaceae) has resulted in the isolation of four known constituents, 1,5-dihydroxy-7-methoxy-3-methylanthraquinone (1), diosgenin-3-O-[alpha-L-rhamnopyranosyl-(1 --> 3)-beta-D-glucopyranoside] (2), diosgenin-3-O-[alpha-L-rhamnopyranosyl...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701192777
更新日期:2007-04-01 00:00:00
abstract::The phytochemical constituents in the aqueous methanolic leaf extract of Triclisia gilletii responsible for its nephroprotective potentials against ethane-1,2-diol induced nephrolithiasis as previously investigated in our laboratory were elucidated. The extract was prepared using 80% aqueous methanol in 72 h, Phytoche...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1845672
更新日期:2020-11-12 00:00:00
abstract::In this study, the batch removal of copper(II) ions from an aqueous solution and wastewater using marine brown alga Sargassum sp. was investigated. Activated carbon prepared from Sargassum sp. by acid decomposition was also used for the removal of copper from the aqueous solution and wastewater. Activated carbon-prepa...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410903064915
更新日期:2010-03-01 00:00:00
abstract::This study investigated the pharmacokinetics of hesperidin (HP), ferulic acid (FA) and p-coumaric acid (CA) in rat plasma after oral administration of Portulaca oleracea L. extract (POE). The plasma concentrations were determined by HPLC with vitexin-2″-O-rhamnoside (VR) as internal standard. The calibration curves we...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.648193
更新日期:2012-01-01 00:00:00
abstract::The fungus showing homology with Nodulisporium by 28S ribosomal gene sequencing, which has been discovered as an endophyte on medicinal plant Nothapodytes foetida, was found to produce 45 and 5.5 microg of camptothecin (CPT) per gram of mycelia at bioreactor and at shake flask, respectively, which was further quantifi...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410902750944
更新日期:2009-01-01 00:00:00
abstract::Oregano (Origanum vulgare L.) is a common aromatic plant used in Mediterranean and Asian Regions for treating respiratory diseases, painful menstruation, rheumatoid arthritis, etc. Recently its role as an anticancer plant has been suggested, although oregano has been never evaluated into adrenocortical tumour cell mod...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1425846
更新日期:2019-06-01 00:00:00
abstract::Formulations of traditional medicines are usually made up of a complex mixture of herbs. However, effective quality control methods in order to select materials of the right quality are lacking. 'Amukkara choornam' is a polyherbal Siddha formulation used for gastritis, spleen enlargement, leucorrhoea, hiccups, anaemia...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.497147
更新日期:2010-12-01 00:00:00
abstract::Bothrops jararacussu venom's (Bj2015) batch was biomonitored quarterly for one year to assess phospholipase A2 (PLA2) activity, immunogenicity, neurotoxicity, and myotoxicity. In silico models were applied to evaluate losses using decay model and recoveries by predictive trend analysis. Mice were immunized with Bj2015...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1446010
更新日期:2019-08-01 00:00:00
abstract::Further studies on Plectranthus sp. (Lamiaceae) led to the isolation of terpenes and phenol esters from Plectranthus strigosus Benth. ent-16-Kauren-19-ol (1), ent-16-kauren-19-oic acid (2), xylopic acid (3), xylopinic acid (4), hinokiol (5), 4 beta,6 beta-dihydroxy-1 alpha,5 beta(H)-guai-9-ene (6) 4 beta,6 beta-dihydr...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701654560
更新日期:2008-01-20 00:00:00
abstract::This study reports for the first time in the chemical composition of acetone, ether, ethyl acetate and dichloromethane extracts of Hypogymnia tubulosa determined by HPLC-UV, GC-FID and GC-MS as well as effect of H. tubulosa acetone extract on micronucleus distribution on human lymphocytes and on cholinesterase activit...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1375926
更新日期:2018-11-01 00:00:00
abstract::A new resin glycoside, named calysolin XVIII (1), was isolated from the leaves, stems and roots of Calystegia soldanella Roem. et Schult. (Convolvulaceae). The structure of 1 was defined as 11S-jalapinolic acid 11-O-β-d-glucopyranosyl-(1 → 3)-O-(2-O-2S-methylbutyryl,4-O-3-hydroxy-2-methylenebutyryl)-α-l-rhamnopyranosy...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1280492
更新日期:2017-11-01 00:00:00
abstract::The proposed work, aims to provide a "green" and cutting-edge technique for the mordanting and dyeing of polyester fabric with natural henna dye using the advanced technology of micro waves. For providing a complete "green" and ecofriendly dyeing process, lemon was used as a natural bio mordant with micro waves and re...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1619721
更新日期:2021-01-01 00:00:00
abstract::A new butenolide derivative (1) featuring octyl substitution at γ-position, together with four known analogues (2-5) were isolated from marine-derived Streptomyces koyangensis SCSIO 5802. The structure of 1 was elucidated by HR-MS and NMR spectroscopic data analyses. The absolute configuration of the stereo centre in ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1686368
更新日期:2019-11-06 00:00:00
abstract::A new phthalide derivative, xylarphthalide A (1), along with two known compounds (-)-5-carboxylmellein (2) and (-)-5-methylmellein (3), were isolated from the endophytic fungus Xylaria sp. GDG-102 cultured from the Chinese medicinal plant Sophora tonkinensis. Their structures were identified by MS and NMR experiments,...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1311892
更新日期:2018-04-01 00:00:00
abstract::A new benzophenone glycoside, mitraphenone A (1), together with three known compounds (2-4) were isolated from the leaves of the traditionally used medicinal plant Mitracarpus villosus (Rubiaceae) collected in Nigeria. A combination of one- and two-dimensional NMR spectroscopic and mass spectrometric measurements were...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1306701
更新日期:2017-10-01 00:00:00
abstract::A new androstanoid metabolite, 4α-methyl-9α-methoxyandrosta-8,15-diene-3,17-dione (1), was isolated from a soil fungus Curvularia borreriae (Pleosporaceae) strain HS-FG-237. Its structure was determined by extensive spectroscopic and X-ray diffraction analyses. Compound 1 exhibited poor cytotoxicity toward HCT-116 cel...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1272115
更新日期:2017-05-01 00:00:00
abstract::Phytochemical investigation of Strychnos nitida has led to the isolation of three new racemic pyridocarbazole alkaloids, (±)-stritidas A-C (1-3) and three known monoterpenoid indole alkaloids (4-6). Compounds 2 and 3 represent the first examples of pyridocarbazole alkaloids featuring an N-2-hydroxyethyl moiety. Their ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1385016
更新日期:2018-07-01 00:00:00
abstract::Propolis is a honeybee product that has been used since ancient times because of its therapeutic effects. It can be used in the development of alternative therapies for the treatment of many diseases, and because propolis shows antibacterial action, this work was carried out in order to investigate a possible synergis...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786411003754355
更新日期:2012-01-01 00:00:00
abstract::In this computational study, geometric factors are calculated by applying semi-empirical methods (PM3) that support experimental evidence from this lab where bryostatins can bind trivalent iron with six Fe-O bonds forming an octahedral geometry. The geometric factors are calculated for all 20 structures (Fe3+ bound to...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410701590087
更新日期:2008-03-20 00:00:00
abstract::From the fruiting body of ectomycorrhizal fungi Cortinarius xiphidipus, sterols were identified from the crude extract and the cytotoxic effect of ergosta-4, 6, 8(14), 22-tetraen-3-one (ergone) was evaluated. Ten sterols including ergosta-3,5,7,9(11),22-pentaene, (22E)-ergosta-5,7,9(11),22-tetraen-3b-ol, (3β,22E)-ergo...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1185717
更新日期:2017-02-01 00:00:00
abstract::Cardiac glycosides are used for treatment of irregular heartbeats, cardiac arrhythmia and congestive heart failures. In this research, digitoxin as a cardiac glycoside was identified and isolated for the first time in the world from Adonis aestivalis and investigated for its cytotoxic activity against cervical cancer ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1413573
更新日期:2019-03-01 00:00:00