Abstract:
:A new triterpene saponin (1) was isolated from a methanol extract of Swartzia apetala Raddi var. glabra, together with the flavonoids mauritianin (2), kaempferol (3) and the triterpene saponin β-D-glucopyranosyl 3β-hydroxy-olean-12-en-28-oate (4). These compounds were characterised on the basis of their spectral data, mainly one-dimension (1D; (1)H, (13)C, APT) and two-dimension (2D; (1)H-(1)H-COSY, HMQC and HMBC) nuclear magnetic resonance (NMR) and HR-ESI-MS, and comparison with values in the literature. The analysis by HR-ESI-MS showed a mass compatible with that of triterpene saponin 1. This proposal was supported by molecular modelling. LC-HR-ESI-MS experiment was also used to evaluate the purity of 1 and allowed to speculate about the possibility of the presence of 5 in very small quantity. The extract and four compounds were assayed for antifungal activity against nine strains of Candida spp.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
de Araújo MF,Curcino Vieira IJ,Sant'Anna CM,da Silva DR,Vitorino Maia AI,Braz-Filho R,Vieira-da-Motta O,Mathias Ldoi
10.1080/14786419.2013.782493subject
Has Abstractpub_date
2013-10-01 00:00:00pages
1888-95issue
20eissn
1478-6419issn
1478-6427journal_volume
27pub_type
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