Metabolites from the co-culture of nigranoic acid and Umbelopsis dimorpha SWUKD3.1410, an endophytic fungus from Kadsura angustifolia.

Abstract:

:The ability of the endophytic fungus Umbelopsis dimorpha SWUKD3.1410 to transform the triterpene nigranoic acid (3, 4-secocycloarta-4(28), 24-(Z)-diene-3, 26-dioic acid; 1) was investigated. Co-culture of nigranoic acid with U. dimorpha SWUKD3.1410 yielded six major products, including a new triterpene (2) and 5 known compounds (3-7). Their structures were identified by the extensive 1D, 2D NMR and HR-ESI-MS Data analysis, and by comparison with those reported data. Among them, 2-4 were transformed from nigranoic acid (1), while 5-7 were derived from the culture medium stimulated by the substrate. On the basis of the structures of 2-4, it was proposed that the transformative process probably involved isomerase and hydroxylase, in which the former was rare in fungi. Additionally, all the compounds (1-7) were evaluated for their cytotoxic activity. As a result, compounds 1, 3-5 exhibited weak cytotoxicity against the tested cell lines, while others showed no cytotoxicity.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Wang L,Qin D,Zhang K,Huang Q,Liu S,Han MJ,Dong JY

doi

10.1080/14786419.2016.1255891

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

1414-1421

issue

12

eissn

1478-6419

issn

1478-6427

journal_volume

31

pub_type

杂志文章
  • A new cinnamoylglycoflavonoid, antimycobacterial and antioxidant constituents from Heritiera littoralis leaf extracts.

    abstract::A new cinnamolyglycoflavonoid 3-cinnamoyltribuloside (1), its precursor tribuloside and two known flavonoid glycosides afzelin and astilbin were isolated from Heritiera littoralis Dryand (Sterculiaceae) ethanolic leaf extract. The dichloromethane leaf extract afforded two known pentacyclic triterpenoids, 3β-taraxerol ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2013.863202

    authors: Christopher R,Nyandoro SS,Chacha M,de Koning CB

    更新日期:2014-01-01 00:00:00

  • A new resin glycoside from Calystegia soldanella and its antiviral activity towards herpes.

    abstract::A new resin glycoside, named calysolin XVIII (1), was isolated from the leaves, stems and roots of Calystegia soldanella Roem. et Schult. (Convolvulaceae). The structure of 1 was defined as 11S-jalapinolic acid 11-O-β-d-glucopyranosyl-(1 → 3)-O-(2-O-2S-methylbutyryl,4-O-3-hydroxy-2-methylenebutyryl)-α-l-rhamnopyranosy...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1280492

    authors: Ono M,Kanemaru Y,Yasuda S,Okawa M,Kinjo J,Miyashita H,Yokomizo K,Yoshimitsu H,Nohara T

    更新日期:2017-11-01 00:00:00

  • Senecipyrrolidine, an unusual pyrrolidine alkaloid isolated from Jacobaea gigantea (Desf.) Pelser (Asteraceae).

    abstract::Alkaloids and phenolic compounds are among the most biologically active natural products from the Jacobaea/Senecio genera (Asteraceae). To isolate original natural products directly from Jacobaea gigantea crude polar extracts, centrifugal partition chromatography (CPC) was used. Previously, we reported the phytochemic...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1493584

    authors: Mezache N,Derbré S,Laouer H,Richomme P,Séraphin D,Akkal S

    更新日期:2019-08-01 00:00:00

  • Repellence of the main components from the essential oil of Glycosmis lucida Wall. ex Huang against two stored product insects.

    abstract::A screening of Chinese medicinal herbs and wild plants for agrochemicals was carried out; the essential oil of Glycosmis lucida leaves was found to possess significant repellent activity against Tribolium castaneum and Liposcelis bostrychophila. It was found that the main components included elixene (19.81%), spathule...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2016.1226825

    authors: Guo SS,Zhang WJ,Yang K,Liang JY,You CX,Wang CF,Li YP,Geng ZF,Deng ZW,Du SS

    更新日期:2017-05-01 00:00:00

  • A novel and efficient synthesis of 3,4-dihydroxyphenylacetic ester and amide derivatives/conjugates and assessment of their antioxidant activity.

    abstract::Phenolic acids, a sub-class of polyphenols, are widely studied. By contrary, 3,4-dihydroxyphenylacetic acid is scarcely studied. For this purpose, a series of 3,4-dihydroxyphenylacetic acid ester and amide derivatives/conjugates were synthesised for the first time. A systematic study has been performed to quantitative...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1342090

    authors: Pagoni A,Vassiliou S

    更新日期:2018-06-01 00:00:00

  • A new highly oxygenated pseudoguaianolide with 5-LOX inhibitory activity from Rudbeckia hirta L. flowers.

    abstract::A new highly oxygenated pseudoguaianolide, rudbeckolide (1), was isolated from Rudbeckia hirta L. flowers. The structure of this terpenoid lactone was established on the basis of extensive 1D and 2D NMR spectroscopic analyses. The compound exhibited strong 5-lipoxygenase inhibitory activity (84.9% inhibition at 10 μg/...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2013.825916

    authors: Michael BR,Gedara SR,Amer MM,Stevenson L,Ahmed AF

    更新日期:2013-01-01 00:00:00

  • Determination of chemopreventive role of Foeniculum vulgare and Salvia officinalis infusion on trichloroacetic acid-induced increased serum marker enzymes lipid peroxidation and antioxidative defense systems in rats.

    abstract::Today's world is increasingly seeking ways to replace the synthetic drugs with the therapeutic power of natural products. This study was designed to investigate the protective effects of Foeniculum vulgare (FV) and Salvia officinalis (SO) waters infusions against carcinogen chemical trichloroacetic acid (TCA)-exposure...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410701590426

    authors: Celik I,Isik I

    更新日期:2008-01-10 00:00:00

  • Phenylpropanoids and lignoids from the whole plant of Vaccinium emarginatum and their cytotoxicity against prostate cancer cells.

    abstract::One new naturally occurring quinone, 3',4'-dihydroxy-1,2,6-trimethoxy-[1,1'-biphenyl]-4(1H)-one (1), one new diarylpropane, emarginone A (2), and one new neolignan, emarginone B (3), along with eighteen known compounds have been isolated from the chemical investigation of the EtOAc-soluble fraction of the Vaccinium em...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1655412

    authors: Tu PC,Liang YC,Kao MC,Chao LK,Tseng MH,Lu TL,Sung PJ,Kuo YH

    更新日期:2019-09-09 00:00:00

  • Optimisation of nutritional requirements for dopamine synthesis by calcium alginate-entrapped mutant strain of Aspergillus oryzae EMS-6.

    abstract::The optimisation of nutritional requirements for dopamine (DA) synthesis by calcium alginate-entrapped mutant variant of Aspergillus oryzae EMS-6 using submerged fermentation technique was investigated. A total of 13 strains were isolated from soil. Isolate I-2 was selected as a better producer of DA and improved by e...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2016.1233408

    authors: Ali S,Nawaz W

    更新日期:2017-02-01 00:00:00

  • Effect of monoterpene ester from Blumea axillaris (Lam.) DC and its acetyl derivative against plant pathogenic fungi and their in silico molecular docking.

    abstract::The present study was aimed to isolate active constituents from Blumea axillaris (Lam.) DC (Asteraceae) against phytopathogenic fungi. Bioactivity guided fractionation of the successive n-hexane, chloroform and methanol extract led to the isolation of the monoterpene ester (4 R,5S)-4-hydroxy-7-tigloyloxycarvotanaceton...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1833197

    authors: Sivanandhan S,Pathalam G,Antony S,Michael GP,Balakrishna K,Boovaragamurthy A,Shirota O,Alwahibi MS,El-Shikh MS,Ignacimuthu S

    更新日期:2020-10-16 00:00:00

  • Variation of spacer type and topology of phenyl moiety in 2-pyridone core of 4-oxo-3-N-methylcytisine; effect of synthesized compounds on rat's behavior in conditioned passive avoidance reflex (CPAR) test.

    abstract::Novel derivatives of 4-oxo-3-methylcytisine with phenyl moiety bonded to starting molecule through various spacers were obtained from the 9-amino, -halo, -formyl and 11-halo precursors by reductive alkylation of amines, generation of amide, as well as thio- and carboxamide functions, cross-coupling reactions, aldehyde...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1622106

    authors: Tsypysheva I,Petrova P,Koval'skaya A,Lobov A,Sapozhnikova T,Makara N,Gabdrakhmanova S,Zarudii F

    更新日期:2021-01-01 00:00:00

  • Chemical constituents from the leaves of Melia azedarach.

    abstract::Six compounds, benzyl 3-O-β-D-glucopyranosyl-7-hydroxybenzoate (1), spathulenol (2), 1,7,8-trihydroxy-2-naphtaldehyde (3), quercetin (4), astragalin (5) and 2-methoxy-4-(2-propenyl)phenyl β-D-glucoside (6), were isolated from the leaves of Melia azedarach L. The structure elucidation of compound 1 was discussed in det...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1501690

    authors: Zeng J,Ma RJ,Wang L,Zhang SN,Song HZ,Yang Y,Tan QG

    更新日期:2019-10-01 00:00:00

  • A new carotenoid glycoside from Rehmannia glutinosa.

    abstract::A new carotenoid glycoside, namely neo-rehmannioside (1), together with five known compounds, 6-O-seco-hydroxyaeginetoyl ajugol (2), oxyrehmaionoside B (3), ajugol (4), geniposidic acid (5) and geniposide (6) was isolated from the 95% ethanol extract of dry roots of Rehmannia glutinosa. The structure of the new compou...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2010.514268

    authors: Fu GM,Shi SP,Ip FC,Pang HH,Ip NY

    更新日期:2011-08-01 00:00:00

  • Antitubercular and cytotoxic polyoxygenated cyclohexane derivatives from Uvaria grandiflora.

    abstract::Chromatographic purification of the DCM sub-extract of Uvaria grandiflora led to the isolation and characterization of a new polyoxygenated cyclohexane derivative, grandifloranol (1), together with five known compounds. Among the compounds isolated, zeylenone (3) showed moderate antitubercular activity against Mycobac...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1741579

    authors: Macabeo APG,Flores AIG,Fernandez RAT,Budde S,Faderl C,Dahse HM,Franzblau SG

    更新日期:2020-03-23 00:00:00

  • A new briarane-type diterpenoid from the South China Sea Gorgonian Dichotella gemmacea.

    abstract::One new briarane-type diterpenoid, dichotellide V (1), along with four known analogues, gemmacolide N (2), dichotellide J (3), junceelin A (4) and junceellolide A (5), was isolated from the South China Sea gorgonian Dichotella gemmacea. All of the isolated compounds (1-5) were established by comprehensive analysis of ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2014.987774

    authors: Sun JF,Yang B,Zhou XF,Yang XW,Wang L,Liu Y

    更新日期:2015-01-01 00:00:00

  • Production of camptothecin by hairy roots and regenerated transformed shoots of Ophiorrhiza rugosa var. decumbens.

    abstract::Camptothecin (CPT), the derivatives of which are used clinically for the treatment of metastatic colon cancer, is isolated from intact plants that can be subjected to environmental fluctuations. In vitro cultures may be an alternate and continuous source for year-round production of CPT. Since CPT production by undiff...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2011.559469

    authors: Kamble S,Gopalakrishnan R,Eapen S

    更新日期:2011-10-01 00:00:00

  • Mercury in fish products: what's the best for consumers between bluefin tuna and yellowfin tuna?

    abstract::A total of 205 bluefin and yellowfin tuna samples were examined for mercury detection in order to verify possible differences and have a detailed risk assessment of the two tuna species. The results showed significant higher mercury concentration in muscle tissue of bluefin tuna respect yellowfin tuna (p < 0.001) with...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1309538

    authors: Cammilleri G,Vazzana M,Arizza V,Giunta F,Vella A,Lo Dico G,Giaccone V,Giofrè SV,Giangrosso G,Cicero N,Ferrantelli V

    更新日期:2018-02-01 00:00:00

  • Adherence to the Mediterranean diet in a Sicilian student population.

    abstract::Since the last decades, socio-economic changes have a key role on eating habits affecting the nutritional status and health of people, in particular children and adolescents. The aim of this study was to compare the diet of student population both normal weight and overweight and obese in order to understand their eat...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1402317

    authors: Metro D,Tardugno R,Papa M,Bisignano C,Manasseri L,Calabrese G,Gervasi T,Dugo G,Cicero N

    更新日期:2018-08-01 00:00:00

  • Identification of a cDNA clone specific for the taxol synthesis phase of Taxus chinensis cells by mRNA differential display.

    abstract::In order to identify genes related to Taxol biosynthesis, the mRNA differential display method was employed to compare mRNA populations from suspension cultured Taxus chinensis cells before and after beginning to produce Taxol. From a total display of about 4000 PCR products, 104 were derived from cells during the Tax...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410310001630573

    authors: Hu G,Fan T,Mei X

    更新日期:2004-08-01 00:00:00

  • Studies on the bioactive flavonoids isolated from Azadirachta indica.

    abstract::Two novel natural metabolites, 3-O-butyl-(-)-epicatechin (1) and 3-O-butyl-(-)-epigallocatechin (2), as well as several known substances, (-)-epicatechin (3), (+)-gallocatechin (4), (-)-epigallocatechin (5), azadirachtin A (6), trilinolein (7) and octadecanoic acid-tetrahydrofuran-3,4-diyl ester (8), were isolated fro...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1579808

    authors: Cen-Pacheco F,Ortiz-Celiseo A,Peniche-Cardeña A,Bravo-Ruiz O,López-Fentanes FC,Valerio-Alfaro G,Fernández JJ

    更新日期:2020-12-01 00:00:00

  • Evaluation of the anti-Leishmania activity of ethanol extract and fractions of the leaves from Pityrogramma calomelanos (L.) link.

    abstract::Leishmaniasis is caused by parasites of the genus Leishmania. Recent reports about leishmaniasis show a few number of drugs available, indicating the necessity of new drugs. In this study, the ethanol extract and fractions of Pityrogramma calomelanos (L.) link. (Pteridaceae) were assayed to verify the cytotoxicity and...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2012.686911

    authors: Souza TM,Morais-Braga MF,Saraiva AÁ,Rolón M,Vega C,de Arias AR,Costa JG,Menezes IR,Coutinho HD

    更新日期:2013-01-01 00:00:00

  • Determination of the derivative from ginkgolide B.

    abstract::A new compound decomposed from ginkgolide B(GB) is discovered and identified by MS and UV spectrum. It is the dehydrate of GB, which was named as ginkgolide K before. Differently, it cannot exist independently, but only in equilibrium with GB. It is found first time that 3-hydroxy is active in some solvent. ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410601130547

    authors: Yuan C,Pan J,Hu X

    更新日期:2008-01-01 00:00:00

  • The sesquiterpenes from the stem and leaf of Clausena lansium with their potential antibacterial activities.

    abstract::Two new C13-norsesquiterpenes claulanterpene A (1) and B (2), together with two known sesquiterpenes (3-4), were isolated from methanol extract of the stem and leaf of Clausena lansium collected from Qingyuan county, Guangdong Province, China. Their structures were elucidated on the base of extensive spectroscopic ana...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1741577

    authors: Liu XY,Fu XX,Li YY,Xiong ZH,Li BT,Peng WW

    更新日期:2020-03-25 00:00:00

  • Two new naphthylisoquinoline alkaloids from stems and leaves of Ancistrocladus tectorius.

    abstract::Two new alkaloids, 4'-O-demethylhamatine (1) and ancistrotectoriline C (2), were isolated from the stems and leaves of Ancistrocladus tectorius. These two compounds represent one 5,1'-coupled and one 7,6'-coupled naphthylisoquinoline alkaloid, respectively. Their structures were elucidated by 1D- and 2D-NMR spectra an...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410902836727

    authors: Tang CP,Xin ZQ,Li XQ,Ye Y

    更新日期:2010-07-01 00:00:00

  • Identification and antimicrobial properties of a new alkaloid produced by marine-derived Verrucosispora sp. FIM06-0036.

    abstract::The actinomycete strain FIM06-0036 was isolated from marine sponge sample collected from the East China Sea and identified as Verrucosispora sp. based upon the results of 16S rRNA sequence analysis. One new alkaloid, 2-ethylhexyl 1H-imidazole-4-carboxylate (1), together with a known alkaloid butyl 1H-imidazole-4-carbo...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1689498

    authors: Chen MH,Lian YY,Fang DS,Chen L,Jia J,Zhang WL,Lin R,Xie Y,Bi HK,Jiang H

    更新日期:2019-11-15 00:00:00

  • Anti-poliovirus activity of Nerium oleander aqueous extract.

    abstract::Nerium oleander (NO), a member of the Apocynaceae family, is an ornamental plant. In this study, we evaluated the antiviral activity of hot and cold extract of NO against six different viruses such as herpes simplex virus type 1 (HSV-1), polio virus type 1 (Sb-1), vesicular stomatitis virus (VSV), reovirus type-1 (Reo...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1582046

    authors: Sanna G,Madeddu S,Serra A,Collu D,Efferth T,Hakkim FL,Rashan L

    更新日期:2019-03-25 00:00:00

  • Anticancer activity of oleiferoside B involving autophagy and apoptosis through increasing ROS release in MCF-7 cells and SMMC-7721 cells.

    abstract::Oleiferoside B is a triterpenoid monomer compound, mainly isolated from roots of Camellia oleifera Abel, the underlying mechanism of its antitumour is not clear. In the present study, oleiferoside B potently inhibited SMMC-7721 and MCF-7 cells proliferation and cause cells apoptosis. In addition, it activated an autop...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1739039

    authors: Feng S,Zha Z,Wang Z,Yang P,Wu J,Li X,Xu Q,Liu Y

    更新日期:2020-03-18 00:00:00

  • Three new 3-benzylbenzofuran-2-one derivatives from Homalium brachybotrys (Flacourtiaceae/Salicaceae s. l.).

    abstract::Eight phenolic compounds, including two mixtures of two compounds, were isolated from the ethyl acetate extract of leaves and stems of Homalium brachybotrys. They were identified on the basis of spectroscopic data as quercetin-3-O-beta-glucopyranoside, luteolin-7-O-beta-glucopyranoside, 5,6-dihydro-6-beta-glucopyranos...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410601130679

    authors: Mosaddik A,Forster PI,Waterman PG

    更新日期:2007-11-01 00:00:00

  • A new labdane diterpenoid arabinoside from Conyza blinii.

    abstract::A new diterpenoid glycoside, 14,15-dinor-labdan-13-one-8-O-alpha-L-arabinopyranoside (1), was isolated from Conyza blinii. The structure of this new arabinoside was elucidated on the basis of extensive NMR and HRMS spectroscopy. In addition, the presence of 3R-hydroxyoctadecanoic acid in C. blinii was reported for the...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410701592232

    authors: Su Y,Chen L,Wang D,Chai X,Guo D

    更新日期:2008-04-15 00:00:00

  • Turmerin, the antioxidant protein from turmeric (Curcuma longa) exhibits antihyperglycaemic effects.

    abstract::A wide range of proteinaceous inhibitors are present in plants to protect themselves from hydrolytic enzymes. In this study, turmerin, a water-soluble peptide in turmeric rhizomes, was evaluated for its inhibitory potential against glucosidase and its antioxidant (AO) capacity. Turmerin inhibited α-amylase and α-gluco...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2011.589386

    authors: Lekshmi PC,Arimboor R,Raghu KG,Menon AN

    更新日期:2012-01-01 00:00:00