Abstract:
:Nerium oleander (NO), a member of the Apocynaceae family, is an ornamental plant. In this study, we evaluated the antiviral activity of hot and cold extract of NO against six different viruses such as herpes simplex virus type 1 (HSV-1), polio virus type 1 (Sb-1), vesicular stomatitis virus (VSV), reovirus type-1 (Reo-1), human immunodeficiency virus type-1 (HIV-1), and yellow fever virus (YFV). Interestingly the results of plaque reduction assay demonstrated that both, hot extract and cold extract (breastin) of NO inhibited Sb-1 viral infection.In order to identify the mechanism by which NO exerts its antiviral activity, the virucidal effect, the time of addition and the adsorption assay were carried out. Results demonstrated that NO exerts its effect after infection period, particularly during the first two hours post infection.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Sanna G,Madeddu S,Serra A,Collu D,Efferth T,Hakkim FL,Rashan Ldoi
10.1080/14786419.2019.1582046subject
Has Abstractpub_date
2019-03-25 00:00:00pages
1-4eissn
1478-6419issn
1478-6427pub_type
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