Studies on the bioactive flavonoids isolated from Azadirachta indica.

Abstract:

:Two novel natural metabolites, 3-O-butyl-(-)-epicatechin (1) and 3-O-butyl-(-)-epigallocatechin (2), as well as several known substances, (-)-epicatechin (3), (+)-gallocatechin (4), (-)-epigallocatechin (5), azadirachtin A (6), trilinolein (7) and octadecanoic acid-tetrahydrofuran-3,4-diyl ester (8), were isolated from the bark of Azadirachta indica. The structures of all compounds were established by comprehensive and comparative spectroscopic analysis of NMR and ESI-HRMS data. The new metabolites 1 and 2 represent one of the few examples of natural compounds with a butyl ether group moiety. The acaricidal activity of the compounds was tested using a standard Shaw larval immersion assay. All the compounds, except 7, possess a LD50 value less than or equal to 7.2 mM.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Cen-Pacheco F,Ortiz-Celiseo A,Peniche-Cardeña A,Bravo-Ruiz O,López-Fentanes FC,Valerio-Alfaro G,Fernández JJ

doi

10.1080/14786419.2019.1579808

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

3483-3491

issue

24

eissn

1478-6419

issn

1478-6427

journal_volume

34

pub_type

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