Abstract:
:A new dihydroisocoumarin (1) and a new coumarin (2), along with eight known metabolites (3-10), were isolated from the solid substrate fermentation cultures of the fungus Penicillium purpurogenum MHZ 111. Their structures were elucidated by extensive spectroscopic analysis and comparison of their spectroscopic and physicochemical data with the literature values. Compounds 2 and 8 showed inhibition of nitric oxide production in lipopolysaccharide-activated BV-2 microglial cells with IC50 values of 26.5 and 52.7 μM, respectively.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Sun J,Zhu ZX,Song YL,Ren Y,Dong D,Zheng J,Liu T,Zhao YF,Tu PF,Li Jdoi
10.1080/14786419.2016.1207075subject
Has Abstractpub_date
2017-03-01 00:00:00pages
562-567issue
5eissn
1478-6419issn
1478-6427journal_volume
31pub_type
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