Isoquinoline alkaloids reduce beta-amyloid peptide toxicity in Caenorhabditis elegans.

Abstract:

:Alzheimer's disease (AD) is a multifactorial health problem widespread over the world. Regarding the historical importance of the alkaloids in the central nervous system pharmacology they remain as promising drug candidates against AD. Seven alkaloids from Amaryllidaceae and Fabaceae were evaluated in vivo, in vitro and in silico targets related to the AD pathophysiology. Erythraline and erysodine showed the greatest potential compared to Memantine, a drug currently used in AD therapy, by delaying the Aβ1-42-induced paralysis in the transgenic strain CL2006 Caenorhabditis elegans, an alternative model to assess the impairment of beta-amyloid peptide deposition. The in vitro inhibition of the acetylcholinesterase was observed for the first time for Erythrina alkaloids; however Lycorine was the most active. Docking simulation contributed to comprehend this potential by showing a hydrophobic interaction between acetylcholinesterase and Lycorine in the amino acid residue TRP 84 as well as hydrogen bonds with TRY 121 and ASP 72.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

de Almeida WAM,de Andrade JP,Chacon DS,Lucas CR,Mariana E,de Santis Ferreira L,Guaratini T,Barbosa EG,Zuanazzi JA,Hallwass F,de Souza Borges W,de Paula Oliveira R,Giordani RB

doi

10.1080/14786419.2020.1727471

subject

Has Abstract

pub_date

2020-02-18 00:00:00

pages

1-5

eissn

1478-6419

issn

1478-6427

pub_type

杂志文章
  • 3.5-scFv-β-lactamase, a new protein detector of picric acid, the highly nitrated organic explosive.

    abstract::A new protein detector of 2,4,6-trinitrophenol (TNP, picric acid) is concisely reported herein for the first time. In brief, the gene of a specific scFv fragment, namely 3.5, was fused separately with the gene of β-lactamase and, subsequently, expressed in the periplasmic space of Escherichia coli, affording in such a...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1860977

    authors: Simonovic M,Mix T,Glumac M,Pejin B

    更新日期:2020-12-18 00:00:00

  • The genus Machaerium (Fabaceae): taxonomy, phytochemistry, traditional uses and biological activities.

    abstract::Machaerium, in the family Fabaceae, predominantly is a genus of a Neotropical distribution of trees, shrubs, and lianas occurring from southern Mexico to Brazil and northern Argentina and as far as South America. Several Machaerium species are widely used in traditional medicine and are considered to have multiple med...

    journal_title:Natural product research

    pub_type: 杂志文章,评审

    doi:10.1080/14786419.2014.1003062

    authors: Amen YM,Marzouk AM,Zaghloul MG,Afifi MS

    更新日期:2015-01-01 00:00:00

  • Two novel coumarins bearing an acetophenone derivative from the leaves of Melicope Quercifolia.

    abstract::Meliquercifolins A (1), and B (2), two new coumarins are bearing an acetophenone derivative were isolated from the leaves of Melicope quercifolia along with three known compounds, melicodenines E (3), F (4) and I (5). Structures of two new compounds were identified based on spectroscopic analyses (UV, HR-ESI-MS, 1 D a...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1644634

    authors: Saputri RD,Tjahjandarie TS,Tanjung M

    更新日期:2019-07-22 00:00:00

  • Chemical constituents of Asplenium ruta-muraria L.

    abstract::A phytochemical study of Asplenium ruta-muraria L. (Aspleniaceae) led to the isolation of a new caffeic acid glycoside, 2-O-caffeoyl-β-D-fructofuranosyl-(2 → 1)-α-D-glucopyranoside and an (α, β)-isomeric pair of 2E-caffeoyl-D-glucopyranoside, together with kaempferol-3-O-β-D-[6-E-caffeoyl-β-D-glucopyranosyl-(1 → 2)glu...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2011.599805

    authors: Fan P,Zhao L,Hostettmann K,Lou H

    更新日期:2012-01-01 00:00:00

  • Essential oil from Lippia microphylla Cham. modulates nitric oxide pathway and calcium influx to exert a tocolytic effect in rat uterus.

    abstract::The essential oil of Lippia microphylla (LM-OE) presents several pharmacological activities. This work evaluates the tocolytic effect of LM-OE on rats. LM-OE inhibited phasic contractions and relaxed tonic contractions on rat uterus. Considering that nitric oxide (NO) pathway regulates uterine contraction, LM-OE poten...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1614578

    authors: Silva MDCC,Souza ILL,Vasconcelos LHC,Ferreira PB,Araujo LCDC,Sampaio RS,Tavares JF,da Silva BA,Cavalcante FA

    更新日期:2019-06-05 00:00:00

  • Quantitative analysis of sulphated glycosaminoglycans content of Malaysian sea cucumber Stichopus hermanni and Stichopus vastus.

    abstract::Stichopus hermanni and Stichopus vastus are sea cucumber species from the Stichopodidae family within the coastal waters of Malaysia. The integument of these invertebrates is hypothesised to contain abundant glycosaminoglycans (GAGs). GAGs are divided into non-sulphated and sulphated GAGs. Sulphated GAGs have various ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2010.545354

    authors: Masre SF,Yip GW,Sirajudeen KN,Ghazali FC

    更新日期:2012-01-01 00:00:00

  • A new eremophilenolactone from Senecio nemorensis.

    abstract::A new eremophilane sesquiterpene was isolated from the roots of Senecio nemorensis. Its structure was established as 10alpha-hydroxy-6beta-propionyloxy-1-oxoeremophila-7(11),8-dieno-12,8-lactone on the basis of spectral analysis. ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410801927940

    authors: Meng FJ,Xiao YN,Zhao RJ,Zhao H,Ma QL,Xie WD

    更新日期:2009-01-01 00:00:00

  • Comparison of phenolic acids and flavonoids contents in various cultivars and parts of common lavender (Lavandula angustifolia) derived from Poland.

    abstract::The aim of study was to compare the content of phenolic acids and flavonoids in two cultivars of Lavandula angustifolia: 'Blue River' and 'Ellagance Purple', including flowers and leafy stalks. Total phenolics and total flavonoids contents were determined by UV-Vis spectroscopy. The contents of total phenolics in leaf...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1320792

    authors: Adaszyńska-Skwirzyńska M,Dzięcioł M

    更新日期:2017-11-01 00:00:00

  • A new denudatine type C20-diterpenoid alkaloid from Aconitum sinchiangense W. T. Wang.

    abstract::A new denudatine-type C20-diterpenoid alkaloid, designated as sinchianine (1), together with eight known diterpenoid alkaloids, 12-acetyl-12-epi-napelline (2), 12-epi-napelline (3), neoline (4), talatisamine (5), 14-O-acetylsenbusine A (6) and benzoylaconine (7), songorine (8) and aconitine (9), were isolated from the...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1410814

    authors: Samanbay A,Zhao B,Aisa HA

    更新日期:2018-10-01 00:00:00

  • A new androstanoid metabolite from a soil fungus Curvularia borreriae strain HS-FG-237.

    abstract::A new androstanoid metabolite, 4α-methyl-9α-methoxyandrosta-8,15-diene-3,17-dione (1), was isolated from a soil fungus Curvularia borreriae (Pleosporaceae) strain HS-FG-237. Its structure was determined by extensive spectroscopic and X-ray diffraction analyses. Compound 1 exhibited poor cytotoxicity toward HCT-116 cel...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2016.1272115

    authors: Liu LF,Zhang H,Qi H,Wang XM,Wang JD,Tan GS

    更新日期:2017-05-01 00:00:00

  • Phytochemical analysis and evaluation of antioxidant and antimycobacterial activity of Colletia paradoxa from Brazil.

    abstract::Colletia paradoxa (Spreng.) Esc. (Rhamnaceae, Colletieae) is a medicinal plant, threatened with extinction in Brazil, presenting great morphological variability. Our objective is to investigate the phytochemical components, antioxidant capacity and antimycobacterial activity of different morphotypes of C. paradoxa in ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1598987

    authors: Bastos Záchia NR,Piana M,Dos Santos Siqueira F,da Silva Jesus R,Athayde ML,Essi L,de Campos MMA

    更新日期:2019-04-16 00:00:00

  • Dilatatone, a new chlorinated compound from Parmotrema dilatatum.

    abstract::Chemical investigation of the lichen Parmotrema dilatatum led to the isolation of a new chlorinated compound, named dilatatone (1), along with a known compound, sernanderin (2). Their chemical structures were determined by analysis of their 1 D and 2 D NMR spectra, HRESIMS, and ECD data. Both compounds showed weak α-g...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1716348

    authors: Phan HV,Devi AP,Le HD,Nguyen TT,Nguyen HH,Le TT,Nguyen TH,Sichaem J,Duong TH

    更新日期:2020-01-27 00:00:00

  • Enhancement of phenolic content, antioxidant and cytotoxic activities of Moringa oleifera leaf and seed by suspension culture.

    abstract::Moringa oleifera Lam. family Moringaceae is well known for a wide range of biological activities and a complex phytochemical composition. The current study investigates tissue culture protocols for Moringa oleifera leaves and seeds. For static culture initiation, Murashige and skooge (MS) as a basal medium with hormon...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1744137

    authors: Mustafa R,El-Naggar EMB,Svajdlenka E,Omran G,ELFiky F,El-Hawiet A

    更新日期:2020-03-25 00:00:00

  • A new cycloartane triterpene bisdesmoside from the rhizomes of Actaea vaginata.

    abstract::A new cycloartane triterpene bisdesmoside, soulieoside T (1), and one known compound, oleanolic acid (2), were isolated from the ethanolic extract of the rhizomes of Actaea vaginata. Their structures were elucidated by spectroscopic methods and by comparison with data reported in the literature. Compound 1 was evaluat...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1700509

    authors: Zhang M,Yang Q,Zhang X,Wu H

    更新日期:2019-12-10 00:00:00

  • A new flavanone glycoside isolated from Tournefortia sibirica.

    abstract::A new flavanone glycoside, (2S)-dihydrooroxylin A 7-O-[β-D-apiosyl(1 → 2)]-β-D-glucoside (1), and four known compounds (2-5) were isolated from Tournefortia sibirica L. The chemical structures of these compounds were determined by 1 D and 2 D NMR and HR-ESI-MS spectra, and r...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1512995

    authors: Diao S,Jin M,Jin CS,Wei CX,Sun J,Zhou W,Li G

    更新日期:2019-10-01 00:00:00

  • The effect of harvest periods on the chemical compositions of essential oils of sage (Salvia aucheri L.) leaves.

    abstract::The essential oils of sage leaves (Salvia aucheri Bentham var. canescens Boiss. & Heldr.), growing wild in South Anatolia, were extracted by hydrodistillation and analysed by GC and GC-MS. The percentage yields of the essential oils from sage leaves harvested at different years were 1.0%, 1.3%, 1.3%, 1.0%, 1.4%, 1.5% ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2011.643309

    authors: Figueredo G,Chalchat JC,Chalard P,Özcan MM,Al Juhaimi FY

    更新日期:2012-01-01 00:00:00

  • Chemical composition, antioxidant activity and cytotoxicity on tumour cells of the essential oil from flowers of Magnolia grandiflora cultivated in Iran.

    abstract::Magnolia grandiflora (Magnoliaceae) is an evergreen tree with fragrant and showy flowers native to southeastern USA but widely cultivated all over the world and used in cosmetics industry in treatment of skin diseases. Here, we report on the chemical analysis of the essential oil obtained from flowers of plants cultiv...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1303699

    authors: Morshedloo MR,Quassinti L,Bramucci M,Lupidi G,Maggi F

    更新日期:2017-12-01 00:00:00

  • Two new eremophilenolides from the roots of Ligulariopsis shichuana and their anti-phytopathogenic fungal and antifeedant activities.

    abstract::Two new eremophilenolides, ligushicins A (1) and B (2), and two known compounds including β-sitosterol and ursolic acid were isolated from Ligulariopsis shichuana. The structures of new compounds were established on the basis of 1D and 2D NMR data and HRESIMS data interpretation. The absolute configuration of new comp...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1419240

    authors: Wu H,Liu T,Lian Y,Wang W

    更新日期:2019-05-01 00:00:00

  • Insecticidal activity of the essential oil of Perovskia artemisioides Boiss.

    abstract::This work reports the phytochemical profile and insecticidal properties of Perovskia artemisioides Boiss essential oil (PAEO) collected in Baluchestan, Iran. Totally, twenty-six substances were identified with 1,8-cineole (25.81%), geranyl acetate (13.00%) and linalool (10.21%) as dominant chemical metabolites by GC-M...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1803311

    authors: Sadeghi Z,Alizadeh Z,Khorrami F,Norouzi S,Moridi Farimani M

    更新日期:2020-08-26 00:00:00

  • 6-O-methylkrigeine, a new amaryllidaceae alkaloid from Nerine huttoniae Schönland.

    abstract::A novel Amaryllidaceae alkaloid, 6-O-methylkrigeine, has been isolated from Nerine huttoniae and the configuration was elucidated by 1-D and 2-D (1)H-NMR, (13)C-NMR, HRMS and optical rotation. ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2010.533668

    authors: Molander M,Christensen SB,Jäger AK,Olsen CE,Rønsted N

    更新日期:2012-01-01 00:00:00

  • A modified oligostilbenoid, diptoindonesin C, from Shorea pinanga Scheff.

    abstract::A new oligostilbenoid, diptoindonesin C, has been isolated from the tree bark of Shorea pinanga Scheff., along with the two known oligostilbenoids gnetin H and hopeaphenol, and a known coumarin scopoletin. The new oligostilbenoid was moderately active against brine shrimps Artemia salina. ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410600761235

    authors: Syah YM,Hakim EH,Ghisalberti EL,Jayuska A,Mujahidin D,Achmad SA

    更新日期:2009-01-01 00:00:00

  • A novel antiplasmodial 3',5'-diformylchalcone and other constituents of Friesodielsia obovata.

    abstract::Phytochemical investigation of the stem and root barks of Friesodielsia obovata Benth (Annonaceae) afforded new 3',5'-diformyl-2',4',6'-trihydroxychalcone and N-formyl-7-hydroxyglaucine together with five known compounds, 3',5'-dimethyl-2',4',6'-trihydroxychalcone, (-)-crotepoxide, demethoxymatteucinol, lawinal, and b...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410701194310

    authors: Joseph CC,Magadula JJ,Nkunya MH

    更新日期:2007-09-01 00:00:00

  • Podophyllotoxin and other aryltetralin lignans from Eriope latifolia and Eriope blanchetii.

    abstract::Phytochemical investigation of the aerial parts of Eriope blanchetii and E. latifolia (Lamiaceae) yielded podophyllotoxin, as well as the aryltetralin lignans α- and β-peltatin and yatein. Oleanolic, ursolic and epikatonic acids were also isolated. This is the first occurrence of podophyllotoxin in the family. ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410902809500

    authors: Santos EO,Lima LS,David JM,Martins LC,Guedes ML,David JP

    更新日期:2011-09-01 00:00:00

  • 2,4,5-Tribromo-1H-imidazole in the egg masses of three muricid molluscs.

    abstract::From analysis by gas chromatography/mass spectrometry (GC/MS), the presence of either 2,4,5-tribromo-1H-imidazole (1) or 3,4,5-tribromo-1H-pyrazole (2) was tentatively identified in lipophilic extracts from the egg masses of three muricid molluscs. Synthesis of these compounds, followed by comparison of the GC retenti...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/1478641031000620682

    authors: Benkendorff K,Pillai R,Bremner JB

    更新日期:2004-10-01 00:00:00

  • A new briarane-type diterpenoid from the South China Sea Gorgonian Dichotella gemmacea.

    abstract::One new briarane-type diterpenoid, dichotellide V (1), along with four known analogues, gemmacolide N (2), dichotellide J (3), junceelin A (4) and junceellolide A (5), was isolated from the South China Sea gorgonian Dichotella gemmacea. All of the isolated compounds (1-5) were established by comprehensive analysis of ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2014.987774

    authors: Sun JF,Yang B,Zhou XF,Yang XW,Wang L,Liu Y

    更新日期:2015-01-01 00:00:00

  • Abscisic acid identification in Okra, Abelmoschus esculentus L. (Moench): perspective nutraceutical use for the treatment of diabetes.

    abstract::Okra, Abelmoschus esculentus L. (Moench), also known as Lady's Fingers, gombo, or bamje, is an annual plant belonging to the Malvaceae family. Traditional olistic medicine since centuries directly associates this plant and its parts to a beneficial health hypoglycemic effect. Since the abscisic acid (ABA) has been ass...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1637874

    authors: Daliu P,Annunziata G,Tenore GC,Santini A

    更新日期:2020-01-01 00:00:00

  • Antibacterial effects of Brazilian and Bulgarian propolis and synergistic effects with antibiotics acting on the bacterial DNA and folic acid.

    abstract::Propolis is a honeybee product that has been used since ancient times because of its therapeutic effects. It can be used in the development of alternative therapies for the treatment of many diseases, and because propolis shows antibacterial action, this work was carried out in order to investigate a possible synergis...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786411003754355

    authors: Orsi RO,Fernandes A Jr,Bankova V,Sforcin JM

    更新日期:2012-01-01 00:00:00

  • Optimization of polysaccharides extraction from quince peels: partial characterization, antioxidant and antiproliferative properties.

    abstract::In this study, Box-Behnken Design was used to optimize the ultrasonic extraction of polysaccharides from quince peels (QPPs) by ascorbic acid and the effect of extraction temperature, extraction time and pH was evaluated. Under optimized conditions of temperature 90 °C, 60 min sonication time and pH = 3.26, the extrac...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1514403

    authors: Dammak MI,Mzoughi Z,Chakroun I,Mansour HB,Le Cerf D,Majdoub H

    更新日期:2020-05-01 00:00:00

  • Undescribed benzophenone and xanthones from cave-derived Streptomyces sp. CB09001.

    abstract::A new benzophenone huanglongmycin (HLM) D (1) and two new monomeric xanthones huanglongmycin E (2) and F (3), together with four known aromatic polyketides aloesaponarin II (4) and the previously isolated huanglongmycin A-C (5-7) were obtained from cave-derived Streptomyces sp. CB09001. The structures of 1-3 were esta...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1813134

    authors: Jiang L,Xiang J,Zhu S,Tang D,Gong B,Pu H,Duan Y,Huang Y

    更新日期:2020-09-01 00:00:00

  • Chemical constituents from the leaves of Melia azedarach.

    abstract::Six compounds, benzyl 3-O-β-D-glucopyranosyl-7-hydroxybenzoate (1), spathulenol (2), 1,7,8-trihydroxy-2-naphtaldehyde (3), quercetin (4), astragalin (5) and 2-methoxy-4-(2-propenyl)phenyl β-D-glucoside (6), were isolated from the leaves of Melia azedarach L. The structure elucidation of compound 1 was discussed in det...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1501690

    authors: Zeng J,Ma RJ,Wang L,Zhang SN,Song HZ,Yang Y,Tan QG

    更新日期:2019-10-01 00:00:00