Isoquinoline alkaloids reduce beta-amyloid peptide toxicity in Caenorhabditis elegans.

Abstract:

:Alzheimer's disease (AD) is a multifactorial health problem widespread over the world. Regarding the historical importance of the alkaloids in the central nervous system pharmacology they remain as promising drug candidates against AD. Seven alkaloids from Amaryllidaceae and Fabaceae were evaluated in vivo, in vitro and in silico targets related to the AD pathophysiology. Erythraline and erysodine showed the greatest potential compared to Memantine, a drug currently used in AD therapy, by delaying the Aβ1-42-induced paralysis in the transgenic strain CL2006 Caenorhabditis elegans, an alternative model to assess the impairment of beta-amyloid peptide deposition. The in vitro inhibition of the acetylcholinesterase was observed for the first time for Erythrina alkaloids; however Lycorine was the most active. Docking simulation contributed to comprehend this potential by showing a hydrophobic interaction between acetylcholinesterase and Lycorine in the amino acid residue TRP 84 as well as hydrogen bonds with TRY 121 and ASP 72.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

de Almeida WAM,de Andrade JP,Chacon DS,Lucas CR,Mariana E,de Santis Ferreira L,Guaratini T,Barbosa EG,Zuanazzi JA,Hallwass F,de Souza Borges W,de Paula Oliveira R,Giordani RB

doi

10.1080/14786419.2020.1727471

subject

Has Abstract

pub_date

2020-02-18 00:00:00

pages

1-5

eissn

1478-6419

issn

1478-6427

pub_type

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