Isoquinoline alkaloids reduce beta-amyloid peptide toxicity in Caenorhabditis elegans.

abstract：:Pigeon Pea is a well-received traditional nutritious and medicinal plant in India since ancient times. The plant is identified for its impressive pharmacological activities like antimicrobial, anti-inflammatory, antitubercular, antioxidant, neuroprotective, antihypertensive, antihyperglycemic and anticancer properties...

journal_title：Natural product research

authors： Dinore JM,Farooqui M

更新日期：2020-11-23 00:00:00

abstract：:Immature dendritic cells (iDCs) play very important roles in the pathological process of rheumatoid arthritis (RA). Therefore, it is urgent to search for natural products with antiproliferative activity on iDCs for anti-RA drug discovery. Erycibe schmidtii, a traditional Chinese medicine, has been used to treat RA in ...

journal_title：Natural product research

authors： Ren W,Wang Y,He Q,Zhou Y,Li C,Wang W,Leng X,Zeng T,Zou Q,Li L

更新日期：2020-09-01 00:00:00

abstract：:Nerium oleander (NO), a member of the Apocynaceae family, is an ornamental plant. In this study, we evaluated the antiviral activity of hot and cold extract of NO against six different viruses such as herpes simplex virus type 1 (HSV-1), polio virus type 1 (Sb-1), vesicular stomatitis virus (VSV), reovirus type-1 (Reo...

journal_title：Natural product research

authors： Sanna G,Madeddu S,Serra A,Collu D,Efferth T,Hakkim FL,Rashan L

更新日期：2019-03-25 00:00:00

abstract：:A wide range of proteinaceous inhibitors are present in plants to protect themselves from hydrolytic enzymes. In this study, turmerin, a water-soluble peptide in turmeric rhizomes, was evaluated for its inhibitory potential against glucosidase and its antioxidant (AO) capacity. Turmerin inhibited α-amylase and α-gluco...

journal_title：Natural product research

authors： Lekshmi PC,Arimboor R,Raghu KG,Menon AN

更新日期：2012-01-01 00:00:00

abstract：:Plants mentioned in this study have numerous records in traditional Peruvian medicine being used in treatment of cancer and other diseases likely to be associated with oxidative stress. Amongst the eight plant species tested, only Dysphania ambrosioides exhibited combinatory antioxidant and anti-proliferative effect o...

journal_title：Natural product research

authors： Tauchen J,Huml L,Bortl L,Doskocil I,Jarosova V,Marsik P,Frankova A,Clavo Peralta ZM,Chuspe Zans ME,Havlik J,Lapcik O,Kokoska L

更新日期：2019-09-01 00:00:00

abstract：:Azadirachtin-A (Aza-A, figure 1) was subjected to a variety of synthetic transformations and the antifeedant activity and toxicity of the azadirachtin derivatives were assessed against second instar larvae Spodoptera litura on castor leaves in comparison with the crude material containing 9.14% Aza-A, as well as relat...

journal_title：Natural product research

authors： Deota PT,Upadhyay PR

更新日期：2005-07-01 00:00:00

abstract：:Botryodiplodia theobromae Pat. belongs to the endophytic fungi that live within the tissues of medicinal plants and produce bioactive natural products. The endophyte was isolated from the leaves of Dracaena draco L. The LC-MS-based metabolite fingerprinting of the ethyl acetate extract of B. theobromae with antibacter...

journal_title：Natural product research

authors： Zaher AM,Moharram AM,Davis R,Panizzi P,Makboul MA,Calderón AI

更新日期：2015-01-01 00:00:00

abstract：:One new flavonoid, 5,7,8,4'-tetrahydroxy-3-methoxyflavone-8-O-β-d-xylopyranoside (2), along with other four known flavones (1, 3-5) were isolated from the aerial parts of Solanum rostratum. 8-hydroxyflavonoid was isolated from series Androceras for the first time. The structure of the new compound 2 was determined on ...

journal_title：Natural product research

authors： Huang HJ,Ling TJ,Wang HM,Cao AC,Zhang CX,Wei SH

更新日期：2017-08-01 00:00:00

abstract：:Leishmaniasis is caused by parasites of the genus Leishmania. Recent reports about leishmaniasis show a few number of drugs available, indicating the necessity of new drugs. In this study, the ethanol extract and fractions of Pityrogramma calomelanos (L.) link. (Pteridaceae) were assayed to verify the cytotoxicity and...

journal_title：Natural product research

authors： Souza TM,Morais-Braga MF,Saraiva AÁ,Rolón M,Vega C,de Arias AR,Costa JG,Menezes IR,Coutinho HD

更新日期：2013-01-01 00:00:00

abstract：:The fungus showing homology with Nodulisporium by 28S ribosomal gene sequencing, which has been discovered as an endophyte on medicinal plant Nothapodytes foetida, was found to produce 45 and 5.5 microg of camptothecin (CPT) per gram of mycelia at bioreactor and at shake flask, respectively, which was further quantifi...

journal_title：Natural product research

authors： Rehman S,Shawl AS,Kour A,Sultan P,Ahmad K,Khajuria R,Qazi GN

更新日期：2009-01-01 00:00:00

abstract：:Among phenolic compounds, Agave americana L. extract contained puerarin (38.4%) and p-coumaric acid (12.29%) (pCa). From the Lineweaver-Burk plots, pCa and puerarin demonstrated a competitive and a non competitive inhibitions towards human α-amylase activity, respectively. PCa exhibited a higher human inhibitory activ...

journal_title：Natural product research

authors： Sahnoun M,Bejar S,Daoud L,Ayadi L,Brini F,Saibi W

更新日期：2019-03-01 00:00:00

abstract：:Glaucocalyxin A is a natural ent-Kaurane diterpenoid. It has been widely studied for some important biological activities like cytotoxicity and anti-tumour, anti-bacterial, anti-oxidative, anti-coagulative, anti-thrombotic, immune and anti-neuroinflammatory activities. The aim of the present article is to review the a...

journal_title：Natural product research

authors： Xiang Z,Wu X,Liu X,Jin Y

更新日期：2014-01-01 00:00:00

abstract：:Two new lupene-type triterpenoids, 3β,6β-dihydroxylup-20(29)-en-28-oic acid β-glucopyranosyl ester (1) and 2α-acetoxyl-3β,6β-dihydroxylup-20(29)-en-28-oic acid β-glucopyranosyl ester (2), along with 18 known compounds, were isolated from Liquidambar formosana. The structures were elucidated on the basis of spectroscop...

journal_title：Natural product research

authors： Yu J,Liu S,Xuan L

更新日期：2012-01-01 00:00:00

abstract：:The cholesteryl ester transfer protein (CETP), inhibition of which assists in maintaining a high level of high-density lipoprotein cholesterol in the blood, is a target for anti-atherosclerosis treatments. Orange monascus pigment was produced by a Monascus species in a 5 L jar fermenter and various derivative compound...

journal_title：Natural product research

authors： Jang H,Choe D,Shin CS

更新日期：2014-01-01 00:00:00

abstract：:The use of a matrix solid-phase dispersion (MSPD) process to extract polyphenols from hawthorn (Crataegus oxyacantha L.) a deciduous shrub with an expected rich phytochemical profile, has been evaluated. MSPD extracts of fruits and leaves have an outstanding content of polyphenols, although the particular phenolic pro...

journal_title：Natural product research

authors： Benabderrahmane W,Lores M,Lamas JP,Benayache S

更新日期：2018-05-01 00:00:00

abstract：:Citrinin dimeric derivatives are bioactive polyketides previously reported from Penicillium, Aspergillus and Monascus fungi species. Due to the large distance between the stereogenic centers of the two monomer units, it was difficult to determine the absolute configuration of the whole molecule (1). In previous work, ...

journal_title：Natural product research

authors： Cao F,Sun TT,Yang JK,Zhao GZ,Liu QA,Hu LD,Ma ZY,Zhu HJ

更新日期：2019-08-01 00:00:00

abstract：:Mangrove plants are endowed with various biologically active compounds which have potent antibacterial and antioxidant properties. In present study, a bioactivity-guided fractionation for antibacterial and antioxidant active metabolites from the twigs of Avicennia officinalis collected from Kuala Selangor Nature Park,...

journal_title：Natural product research

authors： Assaw S,Mohd Amir MIH,Khaw TT,Bakar K,Mohd Radzi SA,Mazlan NW

更新日期：2020-08-01 00:00:00

abstract：:Aim of the present study was to evaluate the potential beneficial and/or adverse effects of Capsicum annuum L. (cv. Fiesta) extracts at two stage of ripening (immature and mature), and at two dosages (low and high) by evaluation of biochemical profile and oxidative status in CD-1 mice. The extracts were daily administ...

journal_title：Natural product research

authors： Morittu VM,Pero ME,Musco N,Mastellone V,Tudisco R,Provenzano E,Britti D,Menichini F,Infascelli F,Lombardi P

更新日期：2020-06-01 00:00:00

abstract：:N-methylasimilobine (1), a new-found strong acetylcholinesterase (AChE) inhibitor, along with two weakly active aporphine alkaloids, nuciferine (2) and nornuciferine (3) were separated from Nelumbo nucifera. N-methylasimilobine (1) inhibited 50% of AChE activity at the concentrations of 1.5 ± 0.2 µg mL(-1) when the st...

journal_title：Natural product research

authors： Yang ZD,Zhang X,Du J,Ma ZJ,Guo F,Li S,Yao XJ

更新日期：2012-01-01 00:00:00

abstract：:A series of new thiazolyl chalcones, 1-[2-amino-4-methyl-1,3-thiazol-5-yl]-3-aryl-prop-2-en-1-one were prepared by piperidine mediated Claisen-Schmidt condensation of thiazolyl ketone with aromatic aldehyde. These chalcones on cyclisation gave 2-amino-6-(2-amino-4-methyl-1,3-thiazol-5-yl)-4-aryl-4H-pyridine-3-carbonit...

journal_title：Natural product research

authors： Venkatesan P,Maruthavanan T

更新日期：2012-01-01 00:00:00

abstract：:This study describes the in vitro inhibition of protein denaturation of extract/fractions of Withania somnifera and isolated withanolides including 20β hydroxy-1-oxo(22R)-witha-2,5,24 trienolide (1), (20R,22R-14α,20α)-dihydroxy-1-oxowitha-2,5,16,24 tetraenolide (2). The results showed that the extract/fractions of the...

journal_title：Natural product research

authors： Khan MA,Khan H,Rauf A,Ben Hadda T

更新日期：2015-01-01 00:00:00

abstract：:In an attempt to establish the components responsible for the use of Enantia chlorantha against cutaneous leishmaniasis in local traditional medicine, a well-known palmatine has been isolated in substantial amounts from a methanolic bark extract of this plant species. Palmatine therein obtained exhibited a significant...

journal_title：Natural product research

authors： Nkwengoua ET,Ngantchou I,Nyasse B,Denier C,Blonski C,Schneider B

更新日期：2009-01-01 00:00:00

abstract：:A continuous phytochemical study on the seeds of Senna obtusifolia (Syn.: Cassia obtusifolia) led to the isolation of a new anthraquinone analogue, obtusifolin-2-O-β-D-(6'-O-α,β-unsaturated butyryl)-glucopyranoside (1) and a new eurotinone analogue, epi-9-dehydroxyeurotinone-β-D-glucopyranoside (2). Their structures w...

journal_title：Natural product research

authors： Pang X,Wang LM,Zhang YC,Kang LP,Yu HS,Fan GW,Han LF

更新日期：2019-12-01 00:00:00

abstract：:Phytochemical investigation of the methanol extract of Euchresta formosana resulted in the isolation of thirty-four compounds. Compounds 1, 3-12, 15, 27, 29 and 32-24 were isolated from this species for the first time. These compounds were identified by spectral analyses and tested for antiplatelet aggregation and ant...

journal_title：Natural product research

authors： Lo WL,Wu CC,Chang FR,Wang WY,Khalil AT,Lee KH,Wu YC

更新日期：2003-04-01 00:00:00

abstract：:Fruits of different Sorbus L. species have been traditionally used in food production and in the treatment of various ailments. Besides common antioxidant active phytochemicals such as ascorbic acid, tocopherols and carotenoids, fruits are rich in phenolic compounds that are of particular interest. In this study, prof...

journal_title：Natural product research

authors： Raudonis R,Raudonė L,Gaivelytė K,Viškelis P,Janulis V

更新日期：2014-01-01 00:00:00

abstract：:Three new compounds; epi-mukulin, (Z)-Δ(1,2) dehydroguggulsterone and Δ(6,7)dehydro-20-hydroxygugglsterone were isolated from the n-hexane-soluble fraction (HSF) of the methanol extract of guggul, the oleogum resin of Commiphora wightii together with six known compounds: diasesartemin, (+)-epi-magnolin, (+)-diayangamb...

journal_title：Natural product research

authors： El-Mekkawy S,Meselhy MR,Nkobole N,Lall N

更新日期：2013-01-01 00:00:00

abstract：:This study was designed to characterise the effects of evodiamine on intestinal contractility and reveal the correlated mechanisms. Evodiamine (2.5-80.0 μM) increased normal jejunal contractility and jejunal hypocontractility established under a variety of experimental conditions. Evodiamine-exerted stimulatory effect...

journal_title：Natural product research

authors： Xiong YJ,Chen DP,Peng JY,Wang JY,Lv BC,Liu FF,Lin Y

更新日期：2015-01-01 00:00:00

abstract：:The compositions of phenolic compounds in 10 cultivars of two mulberry species (Morus atropurpurea Roxb. and Morus alba Linn.) grown in four regions of China were analysed using HPLC-TOF-MS. Results showed that a total of 27 phenolic compounds were identified in these mulberry cultivars. The Taiwan cultivar from the J...

journal_title：Natural product research

authors： Yang J,Zhang X,Jin Q,Gu L,Liu X,Li J,Ni Y

更新日期：2017-05-01 00:00:00

abstract：:Euphorbia hirta (L.) plant is traditionally used in Malaysia for the treatment of gastrointestinal, bronchial and respiratory ailments caused by nosocomial infectious agents. Bioactivity-guided fractionation of the methanol extract of the aerial parts of E. hirta and analysis using high-performance liquid chromatograp...

journal_title：Natural product research

authors： Perumal S,Mahmud R,Ramanathan S

更新日期：2015-01-01 00:00:00

abstract：:From the ethanolic extract of Lentinus edodes (Shiitake) eight known sterols were isolated and identified: ergosterol, ergosterol peroxide, (22E)-ergosta-5,7,9(11), 22-tetraen-3beta-ol, (22E)-ergosta-7,9(11),22-trien-3beta-ol, (22E)-ergosta-6,8,22-trien-3beta-ol, (22E)-norergosta-5,7,9,22-tetraen-3beta-ol, 3beta,5alph...

journal_title：Natural product research

authors： Rivera A,Benavides OL,Rios-Motta J

更新日期：2009-01-01 00:00:00