Antiplasmodial activity of a novel diarylheptanoid from Siphonochilus aethiopicus.

Abstract:

:The Nigerian and South African varieties of Siphonochilus aethiopicus were examined for their phytochemical constituents. The ethyl acetate extract of the rhizomes of the South African variety yielded a novel diarylheptanoid, 2,3-diacetoxy-7-(3'',4''-dihydroxy-5''-methoxyphenyl)-1-(4'-hydroxy-3'-methoxyphenyl)-5-heptene and the flavonoid 3,7-dimethoxyquercetin. From the hexane extract of the Nigerian variety, siphonochilone and another flavonoid, 3,4',7-trimethylkaempferol were isolated. The isolated compounds were characterised by NMR spectroscopic techniques and mass spectrometry. The diarylheptanoid was then assayed for antiplasmodial activity in vitro using a Plasmodium falciparum growth inhibition assay. At the concentrations tested, the compound inhibited parasite growth by 69 - 74%, without producing cytotoxic or significant haemolytic effects. The antiplasmodial activity of the compound is likely mediated by direct mechanism(s) in erythrocytic - stage parasites.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Igoli NP,Al-Tannak NF,Ezenyi IC,Gray AI,Igoli JO

doi

10.1080/14786419.2020.1799358

subject

Has Abstract

pub_date

2020-07-27 00:00:00

pages

1-8

eissn

1478-6419

issn

1478-6427

pub_type

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