Design, synthesis and insecticidal activity of novel semicarbazones and thiosemicarbazones derived from chalcone.

Abstract:

:Thirty semicarbazone and thiosemicarbazone derivatives (2a-w and 4a-g) from chalcones containing furan and thiophene ring were designed and synthesized. They were characterized by IR, 1H NMR, 13C NMR and HRMS. The crystal structure of compound 2r was characterized by single crystal X-ray diffraction. It crystallizes in the monoclinic system with space group P21/c. The insecticidal activity of the synthesized compounds was screened against Leucania separata and Pieris rapae using beta-cypermethrin as the comparative standard. The results displayed that most of them had remarkable insecticidal activity. Among them, compounds 2e-g showed better activity than beta-cypermethrin against L. separata and P. rapae. Compound 2p also possessed a better activity than beta-cypermethrin against P. rapae. The insecticidal activities of these compounds have been reported for the first time.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Cheng W,Xiao T,Qian W,Lu T,Zhang T,Tang X

doi

10.1080/14786419.2020.1739679

subject

Has Abstract

pub_date

2020-03-16 00:00:00

pages

1-9

eissn

1478-6419

issn

1478-6427

pub_type

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