Abstract:
:The investigation on the stems and leaves of Clausena lenis led to the isolation of a previously undescribed carbazole alkaloid, clausenalenine A (1), along with seven known analogues (2-8). The structure of 1 was elucidated based on comprehensive spectroscopic analyses and the known compounds were identified by comparisons with data reported in the literatures. All known compounds (2-8) were isolated from C. lenis for the first time. All isolated compounds were evaluated for their neuroprotective activities against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells in vitro. Compounds 1-8 showed significant neuroprotective effects with EC50 values ranging from 0.68 to 18.76 μM.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Yan G,Li YJ,Zhao YY,Guo JM,Zhang WH,Zhang MM,Fu YH,Liu YPdoi
10.1080/14786419.2019.1652285subject
Has Abstractpub_date
2019-09-16 00:00:00pages
1-8eissn
1478-6419issn
1478-6427pub_type
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