Optimization of polysaccharides extraction from quince peels: partial characterization, antioxidant and antiproliferative properties.

Abstract:

:In this study, Box-Behnken Design was used to optimize the ultrasonic extraction of polysaccharides from quince peels (QPPs) by ascorbic acid and the effect of extraction temperature, extraction time and pH was evaluated. Under optimized conditions of temperature 90 °C, 60 min sonication time and pH = 3.26, the extraction yield, the galacturonic acid yield and the concentration of sample required to scavenge 50% of 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic) acid (ABTS) values of QPPs were respectively 10.25%, 3.86% and 1.35 mg/mL. The QPPs extracted under optimum conditions was characterized by Fourier transform infrared spectroscopy (FTIR), Nuclear magnetic resonance (1 H NMR) and Size exclusion chromatography (SEC/MALS/VD/DRI). The monosaccharide analysis revealed that arabinose was the most abundant, followed by galactose, glucose, mannose and xylose. Moreover, QPPs showed significant antioxidant activities (2,2-diphenyl-1-picrylhydrazyl (DPPH) and Ferric- reducing antioxidant power (FRAP)) and reduced viability of human Caco-2 and murine B-16 cell lines in a dose-dependent manner. Hence QPPs could be used as antitumor agent in functional foods andpharmaceutical industries.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Dammak MI,Mzoughi Z,Chakroun I,Mansour HB,Le Cerf D,Majdoub H

doi

10.1080/14786419.2018.1514403

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

1470-1474

issue

10

eissn

1478-6419

issn

1478-6427

journal_volume

34

pub_type

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