A new sesquiterpenoid with cytotoxic and anti-inflammatory activity from the leaves of Datura metel L.

Abstract:

:A new sesquiterpenoid glycoside, consisting of one vetispirane-type, dmetelisproside A (1), together with two known megastigmane sesquiterpenoids, citroside A (2) and staphylionoside D (3) were isolated from the leaves of Datura metel L. The structures were determined by analysis of their MS and NMR data as well as by comparison with literature values. All isolates were evaluated for cytotoxicity toward SGC-7901, Hepg2, HeLa, MCF-7, and MDA-MB-231 cancer cell lines, and anti-inflammatory activity against nitric oxide (NO) in RAW 264.7 cells in vitro. Compounds 1 and 2 exhibited pronounced cytotoxicity against SGC-7901 and HeLa cells with IC50 values in the range of 21.43 to 29.51 μm. All three compounds displayed potential effects against NO production with IC50 values of 31.10, 34.25, and 44.31 μm, respectively. Thus, these isolated compounds in the leaves of Datura metel L were subjected to bioactivity substances for future studies on medicinal application.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Guo R,Liu Y,Pan J,Guan W,Yang BY,Kuang HX

doi

10.1080/14786419.2019.1590715

subject

Has Abstract

pub_date

2019-03-28 00:00:00

pages

1-7

eissn

1478-6419

issn

1478-6427

pub_type

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