Abstract:
:The present work describes the metabolites produced by a strain identified as Streptomyces youssoufiensis, whose secondary metabolites profile has not been studied so far. The crude ethyl acetate extract was analyzed by high performance liquid chromatography-electrospray ionization mass spectrometry, leading to the detection of the ionophoric polyethers nigericin, epinigericin, abierixin and the newly isolated grisorixin methyl ester. The presence of epimeric forms of nigericin/epinigericin and grisorixin/epigrisorixin has spurred density functional theory computational calculations. This analysis was able to provide the relative stability of the most favored epimers, setting the basis for general structural considerations applicable to several other polyethers. Both nigericin sodium salt and grisorixin methyl ester showed to affect glioblastoma stem cells proliferation in a dose-dependent manner, with a higher activity for the more lipophilic grisorixin methyl ester (GI50 values of 3.85 and 3.05 μM for VIPI and COMI human glioblastoma stem cells, respectively).
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Leulmi N,Sighel D,Defant A,Khenaka K,Boulahrouf A,Mancini Idoi
10.1080/14786419.2018.1446014subject
Has Abstractpub_date
2019-01-01 00:00:00pages
266-273issue
2eissn
1478-6419issn
1478-6427journal_volume
33pub_type
杂志文章abstract::The essential oil of Lippia microphylla (LM-OE) presents several pharmacological activities. This work evaluates the tocolytic effect of LM-OE on rats. LM-OE inhibited phasic contractions and relaxed tonic contractions on rat uterus. Considering that nitric oxide (NO) pathway regulates uterine contraction, LM-OE poten...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1614578
更新日期:2019-06-05 00:00:00
abstract::Cynanchum acutum L. subsp. sibiricum (Willd.) Rech. f. was extracted with hexane, acetone, methanol and water individually. A sample was heated in water then extracted with ethyl acetate. Among the extracts, the ethyl acetate extract exhibited the most antiproliferative activity, so isolation of bioactive compounds wa...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1289201
更新日期:2017-11-01 00:00:00
abstract::This study aimed at evaluating the impact of environmental factors on the accumulation of various components in Hedera helix L. folium collected from different European countries. The obtained results of studied samples showed that the antioxidant capacities were in the range of 0.027 to 0.688 mg/g. Contents of active...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1843029
更新日期:2020-11-04 00:00:00
abstract::The antibacterial activity of essential oil and methanolic extract of Teucrium polium was determined against Pseudomonas aeruginosa, Pantoea agglomerans, Brenneria nigrifluens, Rhizobium radiobacter, Rhizobium vitis, Streptomyces scabies, Ralstonia solanacearum, Xanthomonas campestris and Pectobacterium cartovorum by ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.1000320
更新日期:2015-01-01 00:00:00
abstract::Plants endue a key role against illnesses caused by oxidative stress. These attributes are frequently associated with polyphenolic compounds. However, presence and concentration of secondary metabolites are affected by abiotic factors. The in vitro culture techniques can solve these drawbacks. Peppers can be a suitabl...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1380026
更新日期:2018-05-01 00:00:00
abstract::A simple extraction procedure and HPLC method was developed to analyse the major and minor components of induced phytoalexins of elicited tissues (seeds) of chickpeas (Cicer arietinum L.) and peas (Pisum sativum L.) treated with a biotic elicitor (k-carrageenan) of Hypnea musciformis (red algae) from the Karachi coast...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2011.553952
更新日期:2011-08-01 00:00:00
abstract::The antiradical activity of the freshwater bryozoan Hyalinella punctata water extracts (two samples, seasonal collection) was evaluated by using electron paramagnetic resonance spectroscopy against hydroxyl (√OH), superoxide anion (√O2(- )), methoxy (√CH2OH), carbon-dioxide anion (√CO2(- )), nitric-oxide (√NO) and 2,2...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.921788
更新日期:2014-01-01 00:00:00
abstract::The chemical constituents identified in the essential oils hydrodistilled from the leaves of Amomum gagnepainii T.L.Wu, K.Larsen and Turland and Amomum repoense Pierre ex Gagnep (Zingiberaceae) of Vietnam origin are reported. The chemical analyses were performed by means of gas chromatography-flame ionisation detector...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1346643
更新日期:2018-02-01 00:00:00
abstract::Chromatographic fractionation of the chloroform extracts from the stem bark and stems of Guettarda grazielae resulted in the isolation of a new iridoid (guettardodiol, 1) and the secoiridoid sarracenin (2), described for the first time in this genus. The structural elucidation of these compounds was based on spectrosc...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2010.507547
更新日期:2011-10-01 00:00:00
abstract::Cumin (Cuminum cyminum) is an annual plant from Apiaceae family that is cultivated in Iran as landraces. The most important chemical composition of the cumin essential oil was cuminaldehyde. In this research, the effect of different landraces and growth regulators was evaluated on callus induction, and best callus was...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1272105
更新日期:2017-09-01 00:00:00
abstract::A series of novel hydrocarbylidene nitrohydrazinecarboximidamides were designed and synthesized using an insecticidal natural product Galegine as a lead compound. The bioassay results show that the target compounds exhibited moderate to good insecticidal activities against Hyalopterus pruni Geoffroy at a concentration...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1655409
更新日期:2019-08-20 00:00:00
abstract::SPME analysis of Zingiber officinale Roscoe and Curcuma longa L. were performed by using a DVB/CARB/PDMS fiber. The SPME analysis of Zingiber officinale showed that the main components found were camphene (7.27%), geranial (8.37%), α-zingiberene (14.50%), α-farnesene (9.14%), β-bisabolene (6.52%), and β-sesquiphelland...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1488702
更新日期:2019-07-01 00:00:00
abstract::A total of 25 compounds including terpenoids, flavonoids, biflavonoids and ginkgolic acids were identified and quantified with a reliable, simple, and simultaneous method from Ginkgo leaves, seed coats and embryoids with different tree ages (approximately identified as 25, 500, 1000 and 2000 years). Leaves had the hig...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2020.1788020
更新日期:2020-07-01 00:00:00
abstract::Alternanthera brasiliana is popularly known as 'penicillin' and used as an anti-inflammatory and for wound healing. The objective of this work was the phytochemical study of the species by analytical techniques such as LC-MS/MS and GC-MS. Twenty-seven compounds were identified, five by LC-MS and 22 by GC-MS analysis. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1533827
更新日期:2020-02-01 00:00:00
abstract::New sesquiterpene glycoside, cyclodipeptide and piperidine derivative were isolated from Streptomyces sp. YIM 63342. On the basis of spectral data, their structures were determined as 3R, 5R, 6S, 7E, 9R-megastigman-7-en-3,5,6,9-tetrol-9-O-β-D-apiofuranosyl-(1→ 2)-β-D-glucopyranoside (1), cyclo (L-Pro-L-OMet) (2) and (...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.718776
更新日期:2013-01-01 00:00:00
abstract::4-Methoxybenzene-1-ONN-azoxyformamide (1), 4-methoxybenzene-1-azoformamide (2), 4-hydroxyben-zene-1-azoformamide (3) and 4-hydroxybenzene-1-ONN-azoxyformamide (4) were isolated from the fruiting bodies of Calvatia craniiformis and Lycoperdon hiemale, respectively. Compounds 1 and 4 showed radicle growth inhibitory act...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410600649596
更新日期:2006-05-10 00:00:00
abstract::An aroma chemical emitted from Gerris paludum insularis was analyzed by means of GC and GC-MS. The main constituent was identified as iso amyl alcohol (3-methyl-1-butanol). The chemical showed a characteristic aroma of Gerris paludum insularis. ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410310001620655
更新日期:2004-06-01 00:00:00
abstract::A new natural diketopiperazine (1) was obtained from the culture broth of Microbispora aerata strain imbas-11A, isolated from penguin excrements collected on the Antarctic Livingston Island. Compound 1 was purified consecutively by solvent extraction, silica gel column chromatography and preparative HPLC. The structur...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2012.665911
更新日期:2013-01-01 00:00:00
abstract::A new β-hydroxydihydrochalcone glycoside named ziganin (1) and a new acylated flavonol glycoside named isorhamnetin-3-O-α-L-(2″,3″-di-O-trans-coumaroyl)-rhamnopyranoside) (2), along with two known flavonoid glycosides, a β-hydroxydihydrochalcone glycoside, a hydroxybenzoic acid derivative, a trinorguaiane type sesquit...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2015.1062006
更新日期:2016-01-01 00:00:00
abstract::Phytochemical investigation of Strychnos nitida has led to the isolation of three new racemic pyridocarbazole alkaloids, (±)-stritidas A-C (1-3) and three known monoterpenoid indole alkaloids (4-6). Compounds 2 and 3 represent the first examples of pyridocarbazole alkaloids featuring an N-2-hydroxyethyl moiety. Their ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1385016
更新日期:2018-07-01 00:00:00
abstract::The whole plant, Tricholepis chaetolepis, powder was investigated using proximate and fluorescence analysis along with determining the extractive values. Total phenolics, flavonoids and total protein contents of n-hexane, chloroform and methanolic extracts of the whole plant were also determined. The anti-diabetic act...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1490905
更新日期:2020-02-01 00:00:00
abstract::In the case of Achillea wilhelmsii, 30 compounds were identified representing 94.48% of the total oil with a yield of 0.82% w/w. The major constituents of the oil were described as α-thujene (6.11%), α-pinene (5.11%), sabinene (5.23%), p-cymene (7%), 1,8-cineole (6%), linalool (10%), camphor (8.43%), thymol (18.98%) a...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2014.953949
更新日期:2015-02-01 00:00:00
abstract::In this study, Moringa oleifera flower extract and a trypsin inhibitor (MoFTI) isolated from it were evaluated for anti-protozoal activity against Trypanosoma cruzi and cytotoxicity to mammalian cells. The presence of flavonoids was remarkable in the HPLC fingerprints of the extract at 254 and 360 nm. Amino acid seque...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2017.1389932
更新日期:2018-12-01 00:00:00
abstract::The phytochemical study of the aerial parts of Viburnum chinshanense Graebn., a species growing in Western and Central China, led to the isolation of six iridoid glucosides: the novel 10,2'-diacetylpatrinoside, 1, and the known 2'-acetyldihydropenstemide, 2'-trans- p-coumaroyl-dihydropenstemide, 2'-acetylpatrinoside, ...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410500056678
更新日期:2006-07-10 00:00:00
abstract::The methanolic extract of the Tanacetum gracile afforded the isolation of new sesquiterpene lactone, named gracilone (1) along with four known compounds as 14α-taraxeran-3-one (2), 14α-taraxeran-3-ol (3), apigenin (4) and β-sitosterol (5). The structure of compound 1 was elucidated on the basis of 1D, 2D NMR and MS sp...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1164701
更新日期:2016-10-01 00:00:00
abstract::Timosaponin AIII (TAIII) exhibits extensive pharmacological activities and has been reported as a potent antitumour agent for various human cancers. In the present study, a potential industrial process for producing TAIII that involves biotransformation directly in the crude extract liquid of rhizoma anemarrhenae (RA)...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2016.1169416
更新日期:2016-10-01 00:00:00
abstract::Armoracia rusticana (AR) was tested for antimicrobial and antioxidants power. The compound demonstrated to inhibit fish pathogens such as Vibrio anguillarum, V. harvey, V. alginolyticus, Aeromonas hydrophila, A. salmonicida, Photobacterium damselae subspecie piscicida, Tenacibaculum marinum and Pseudomonas anguillisep...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2018.1517121
更新日期:2020-06-01 00:00:00
abstract::The present study was designed to evaluate the herbicidal activity of Datura metel against the noxious weed parthenium (Parthenium hysterophorus L.). In a laboratory bioassay, the effect of aqueous, methanol and n-hexane shoot and root extracts of 5, 10, 15 and 20% w/v (on a fresh weight basis) concentration of D. met...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410903075440
更新日期:2010-09-01 00:00:00
abstract::A new anthraquinone (4) and three known anthraquinones (1-3) were isolated from Galium verum L. Their structures were identified as 1,3-dihydroxy-2-methylanthraquinone (1), physcion (2), 2-hydroxy-1,3-dimethoxyanthraquinone (3), 2,5-dihydroxy-1,3-dimethoxyanthraquinone (4) by means of chemical and spectroscopic analys...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786410600921532
更新日期:2006-09-01 00:00:00
abstract::Artemisia herba-alba is widely used in traditional medicines for the treatment of several diseases. From the aerial parts organic extract of A. herba-alba, two new compounds, 1,3,8-trihydroxyeudesm-4-en-7α,11βH-12,6α-olide (1) and 5-β-D-glucopyranosyloxy-7-methoxy-6H-benzopyran-2-one (2), respectively, togethe...
journal_title:Natural product research
pub_type: 杂志文章
doi:10.1080/14786419.2019.1647430
更新日期:2019-07-31 00:00:00