Abstract:
:A series of (E)-1-(4-alkyloxyphenyl)-3-(hydroxyphenyl)-prop-2-en-1-one have been successfully synthesised via Claisen-Schmidt condensation. The synthesised chalcone derivatives consisted of hydroxyl groups at either ortho, meta or para position and differed in the length of the alkyl groups, C (n) H(2) (n) (+1,) where n = 6, 10, 12 and 14. The structures of all compounds were defined by elemental analysis, IR, (1)H- and (13)C-NMR. The antimicrobial studies were carried out against wild-type Escherichia coli American Type Culture Collection 8739 to evaluate the effect of the hydroxyl and the alkyl groups of the synthesised chalcones. All the synthesised compounds have shown significant antimicrobial activities. The optimum inhibition was dependent on the position of the hydroxyl group as well as the length of the alkyl chains.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Ngaini Z,Fadzillah SM,Hussain Hdoi
10.1080/14786419.2010.502896subject
Has Abstractpub_date
2012-01-01 00:00:00pages
892-902issue
10eissn
1478-6419issn
1478-6427pii
938653418journal_volume
26pub_type
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