Study of chemical composition and antimicrobial activity of leaves and roots of Scrophularia ningpoensis.

Abstract:

:Two saponins: scrokoelziside A (1), scrokoelziside B (2), one iridoid glycoside, eurostoside (3), and two flavonoids: nepitrin (4) and homoplantaginin (5), were isolated from the leaves of Scrophularia ningpoensis for the first time. Moreover, eight known compounds: cane sugar (6), harpagide (7), aucubin (8), 6-O-methylcatalpol (9), harpagoside (10), angoroside C (11), beta-sitosterol (12) and beta-sitosterol glucoside (13) were isolated from the roots of S. ningpoensis. Furthermore, the antimicrobial activity of the extracts of the leaves of S. ningpoensis and the 10 compounds (1, 2, 3, 4, 5, 7, 8, 9, 10, 11) was studied in vitro against eight reference strains of bacteria by using the disc-diffusion method and micro-well dilution assay. The extracts of leaves and scrokoelziside A are effective against beta-haemolytic streptococci but had no effect against other strains. The extract of roots and other compounds showed no activity against all bacterial strains at the test concentration.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Li J,Huang X,Du X,Sun W,Zhang Y

doi

10.1080/14786410802696247

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

775-80

issue

8

eissn

1478-6419

issn

1478-6427

pii

910952413

journal_volume

23

pub_type

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