Abstract:
:Investigations were performed on the determination of the main components in Berchemia lineata (L.) DC. (BL) and its metabolism with human liver microsomes (HLM). A total of 35 compounds were detected in BL extracts and 25 of them including 6 naphthopyrones, 10 flavonoids, 2 phenolic acids, 2 phenols, 4 fatty acids and 1 quinone were unambiguously or tentatively identified by UPLC-QTOF-MS/MS. Among them, naphthopyrones were first identified in BL extracts and labelled in chromatography. In addition, the weak inhibitory effects of BL extracts (IC50=149.25 μg/mL) and rubrofusarin-6-O-α-L-rhamnosyl-(1-6)-O-β-D-glu-copyranside (the main component of BL extracts, M 0 ; IC50=82.14 μM) on CYP3A4 were also proved using testosterone as specific probe drug. The main metabolic pathway of M 0 by HLM was hydroxylation in its aglycone, the metabolite was tentatively identified as 10-hydroxy-rubrofusarin-6-O-α-L-rhamnosyl-(1-6)-O-β-D-glucopyranside. Components characterisation and the metabolism with HLM could help the further development and application of BL.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Jiang X,Chen S,Guo Z,Gu D,Liang Xdoi
10.1080/14786419.2019.1637871subject
Has Abstractpub_date
2021-02-01 00:00:00pages
521-524issue
3eissn
1478-6419issn
1478-6427journal_volume
35pub_type
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