An unreported bis-abeo cembrane-type diterpenoid with antioxidative and anti-lipoxygenase activities from the muricid gastropod mollusc Chicoreus ramosus.

Abstract:

:The chemical analyses of ethyl acetate-methanol (EtOAc-MeOH) extract of muricid gastropod mollusk, Chicoreus ramosus from the southeastern coast of Indian peninsular led to the identification of unprecedented cembrane-type diterpenoid, which was characterized as (3E, 6E, 10E)-8a-butoxy-17(15→14), 20(12→11)-bis-abeo-cembra-3,6,10,14(17),15-pentaene (1). The structure of the studied cembrane was unambiguously assigned through the extensive spectroscopic experimentations. The antioxidant potentials of the bis-abeo cembrane as determined by in vitro 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis-3-ethylbenzothiozoline-6-sulfonic acid diammonium salt radical quenching potentials were greater (IC50 < 0.40 mg/mL) related to α-tocopherol (IC50 > 0.60 mg/mL). The pro-inflammatory anti-5-lipoxygenase potential of studied cembrane was higher (IC50 < 0.80 mg/mL) related to those demonstrated by ibuprofen and sodium salicylate (IC50 > 0.90 mg/mL).

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Chakraborty K,Salas S,Joy M

doi

10.1080/14786419.2018.1527833

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

1678-1686

issue

12

eissn

1478-6419

issn

1478-6427

journal_volume

34

pub_type

杂志文章
  • Quantitative analysis of sulphated glycosaminoglycans content of Malaysian sea cucumber Stichopus hermanni and Stichopus vastus.

    abstract::Stichopus hermanni and Stichopus vastus are sea cucumber species from the Stichopodidae family within the coastal waters of Malaysia. The integument of these invertebrates is hypothesised to contain abundant glycosaminoglycans (GAGs). GAGs are divided into non-sulphated and sulphated GAGs. Sulphated GAGs have various ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2010.545354

    authors: Masre SF,Yip GW,Sirajudeen KN,Ghazali FC

    更新日期:2012-01-01 00:00:00

  • Development and validation of headspace Solid-Phase microextraction coupled with gas chromatography (HS-SPME-GC) method for the analysis of zingiber zerumbet L.

    abstract::Headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography (GC-FID) was explored to determine the fingerprinting characteristic of Zingiber zerumbet L. volatiles to differentiate between different ginger species. The effect of different fibers [polydimethylsiloxane (PDMS, 7 μm), polyacrylate (PA, ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1643863

    authors: Bhavya ML,Ravi R,Madhava Naidu M

    更新日期:2019-07-22 00:00:00

  • Antitubercular and cytotoxic polyoxygenated cyclohexane derivatives from Uvaria grandiflora.

    abstract::Chromatographic purification of the DCM sub-extract of Uvaria grandiflora led to the isolation and characterization of a new polyoxygenated cyclohexane derivative, grandifloranol (1), together with five known compounds. Among the compounds isolated, zeylenone (3) showed moderate antitubercular activity against Mycobac...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1741579

    authors: Macabeo APG,Flores AIG,Fernandez RAT,Budde S,Faderl C,Dahse HM,Franzblau SG

    更新日期:2020-03-23 00:00:00

  • A new neolignan glycoside from Dolomiaea souliei.

    abstract::One new neolignan glycoside, dolomiside A (1), together with 11 known phenylpropanoid glycosides were isolated from Dolomiaea souliei (Franch.) Shih. The structures of these isolates were determined by UV, CD, HR-ESI-TOFMS, 1D and 2D NMR analysis. ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1552695

    authors: Yi M,Meng FC,Qu SY,Tao YY,Liao ZH,Chen M

    更新日期:2020-04-01 00:00:00

  • The isolation and structural elucidation of three new biflavonoid glycosides from Lomatogonium carinthiacum.

    abstract::Three biflavonoid glycosides, named carinoside B, C and D (1, 2 and 3, respectively), were isolated from the n-BuOH crude extract of the aerial part of Lomatogonium carinthiacum (Wulfen) Rchb (L. carinthiacum). The structures of 1, 2 and 3 were elucidated by spectroscopic methods, including UV, IR, HR-ESI-MS and exten...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2015.1025399

    authors: Bao B,Wang Q,Wu X,Tai W

    更新日期:2015-01-01 00:00:00

  • Anthraquinone derivatives from Micromonospora rhodorangea.

    abstract::From the fermentation broths of the actinomycete Micromonospora rhodorangea, four anthraquinone derivatives (1-4) were isolated, of which 2-ethyl-1,8-dihydroxy-3-methyl-anthraquinone (1) and 3,8-dihydroxy-1-propylanthraquinone (3) were determined as new compounds. Their structures were established by using extensive s...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410600898961

    authors: Xue CM,Tian L,Lin WH,Deng ZW

    更新日期:2009-01-01 00:00:00

  • Supercritical CO2 extract from needles of Pinus nigra ssp. laricio: combined analysis by GC, GC-MS and 13C NMR.

    abstract::The chemical composition of the volatile concentrate prepared by supercritical CO(2) extraction of the needles of Pinus nigra Arnold ssp. laricio Poiret from Corsica was investigated using GC (RI), GC-MS and (13)C NMR spectroscopy. The major component was by far manoyl oxide (63%), a compound of potential interest for...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410701427280

    authors: Duquesnoy E,Marongiu B,Castola V,Piras A,Porcedda S,Casanova J

    更新日期:2007-07-20 00:00:00

  • Pictalignans D-F, three new neolignan derivatives from Selaginella picta.

    abstract::Three new neolignan derivatives (1-3), together with three known isolariciresinol derivatives (4-6) were isolated from Selaginella picta. Their structures were elucidated by spectroscopic methods (1D/2D NMR, HRESIMS and CD). All isolated compounds were assayed on the neuroprotective activity against the injury of HT-2...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1560284

    authors: Cheng F,Zou ZX,Xu PS,Zhang SH,Zhang Y,Yao CP,Xu KP,Tan GS

    更新日期:2020-05-01 00:00:00

  • Salvia x jamensis J. Compton: Trichomes, essential oil constituents and cytotoxic-apoptotic activity.

    abstract::Salvia x jamensis J. Compton is a hybrid between Salvia greggii A. Gray and Salvia microphylla Kunt. In this study, we describe three hair types identified by Scanning Electron Microscopy. In the essential oil of the aerial parts of S. jamensis 56 different compounds were identified. The two main constituents were β-c...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2012.730044

    authors: Fraternale D,Albertini MC,Rudov A,Flamini G,Ricci D,Bisio A,Battistelli M,Accorsi A

    更新日期:2013-01-01 00:00:00

  • Essential oil composition of aerial parts of Cyclospermum leptophyllum (Pers.) Sprague ex Britton and P. Wilson.

    abstract::The essential oil of Cyclospermum leptophyllum (Pers.) Sprague ex Britton and P. Wilson syn. Apium leptophyllum (Pers.) F. Muell. Ex Benth., family Apiaceae (Umbellifereae), was analysed by GC and GC-MS. The essential oil showed the presence of thymohydroquinone dimethyl ether (50.7%), thymol methyl ether (11.2%), γ-t...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2010.487190

    authors: Pande C,Tewari G,Singh C,Singh S

    更新日期:2011-03-01 00:00:00

  • A new furan derivative from an endophytic Aspergillus tubingensis of Decaisnea insignis (Griff.) Hook.f. & Thomson.

    abstract::A new furan derivative named 3-(5-oxo-2,5-dihydrofuran-3-yl) propanoic acid (1) was isolated for the first time. Its structure was elucidated by UV, IR, NMR, HR-ESI-MS and the single-crystal X-ray diffraction spectroscopic data. Meanwhile, the antifungal and antibacterial activities of compound 1 was tested, it exhibi...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1501687

    authors: Yang XF,Wang NN,Kang YF,Ma YM

    更新日期:2019-10-01 00:00:00

  • Iridoid, phenylethanoid and flavonoid glycosides from Forsythia suspensa.

    abstract::As part of our continuing efforts to explore bioactive compounds from natural resources, a new iridoid glycoside, adoxosidic acid-6'-oleuroperic ester (1), together with one known phenylethanoid glycoside (2) and two known flavonoid glycosides (3-4) were isolated from the fruit of Forsythia suspensa. The structure of ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1560288

    authors: Wei Q,Zhang R,Wang Q,Yan XJ,Yu QW,Yan FX,Li C,Pei YH

    更新日期:2020-05-01 00:00:00

  • One bis-indole alkaloid-voacamine from Voacanga africana Stapf: biological activity evaluation of PTP1B in vitro utilizing enzymology method based on SPRi expriment.

    abstract::One known bis-indole alkaloid-voacamine was isolated from Voacanga africana Stapf and Surface Plasmon Resonance imaging (SPRi) exprement showed that this alkaloid could be combine with Protein Tyrosine Phosphatase1B (PTP1B). Then the PTP1B activity inhibition experiment display that the compound showed an outstanding ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1480623

    authors: Wang YQ,Li HX,Liu XC,Zhao JS,Liu RQ,Huai WY,Ding WJ,Zhang TE,Deng Y

    更新日期:2019-12-01 00:00:00

  • Evaluation of topical Matricaria chamomilla extract activity on linear incisional wound healing in albino rats.

    abstract::In this investigation, the effect of Matricaria chamomilla extract on linear incisional wound healing was studied. Thirty male Wistar rats were subjected to a linear 3 cm incision made over the skin of the back. The animals were randomly divided into three experimental groups, as control, olive oil, and treatment. Con...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410701654875

    authors: Jarrahi M,Vafaei AA,Taherian AA,Miladi H,Rashidi Pour A

    更新日期:2010-05-01 00:00:00

  • Three new flavonoids, hippophins K-M, from the seed residue of Hippophae rhamnoides subsp. sinensis.

    abstract::Three new flavonol glycosides (1-3), hippophins K-M, were isolated from the seed residue of Hippophae rhamnoides subsp. sinensis. The chemical structures of these three new compounds were identified by 1D, 2D NMR, mass spectroscopy and high resolution electrospray ionization mass spectrometry spectroscopic data and by...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2013.830216

    authors: Chen C,Gao W,Ou-Yang DW,Zhang J,Kong DY

    更新日期:2014-01-01 00:00:00

  • Comparative larvicidal activity of different species of Ocimum against Culex quinquefasciatus.

    abstract::Ocimum is a genus of aromatic herbs, undershurbs or shrubs distributed in the tropical and warm temperate regions of the world. Larvicidal activity of essential oils and different extracts of O. sanctum, O. basilicum and O. gratissimum were compared on laboratory reared and field collected larvae of Culex quinquefasci...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2010.551755

    authors: Rajamma AJ,Dubey S,Sateesha SB,Tiwari SN,Ghosh SK

    更新日期:2011-12-01 00:00:00

  • Penicindopene A, a new indole diterpene from the deep-sea fungus Penicillium sp. YPCMAC1.

    abstract::A new indole diterpene, named penicindopene A (1), together with seven known compounds (2 - 8), was isolated from the deep-sea fungus Penicillium sp. YPCMAC1. The structure of penicindopene A was elucidated by extensive spectroscopic analyses (1 D and 2 D NMR, and HRESIMS data), in addition to the ECD calculations for...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1514402

    authors: Liu L,Xu W,Li S,Chen M,Cheng Y,Yuan W,Cheng Z,Li Q

    更新日期:2019-10-01 00:00:00

  • Anticancer effect of ethanol Lycium barbarum (Goji berry) extract on human breast cancer T47D cell line.

    abstract::The anticancer activity of ethanol extract isolated from Goji berry (EEGB) on T47D human breast cancer cell line has been reported. Cell viability and cell proliferation were examined with the use of BrdU, MTT and NR methods. Induction of apoptosis was assessed by propidium iodide and Hoechst 33342 staining. Expressio...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2015.1101691

    authors: Wawruszak A,Czerwonka A,Okła K,Rzeski W

    更新日期:2016-09-01 00:00:00

  • Inhibition of thermal induced protein denaturation of extract/fractions of Withania somnifera and isolated withanolides.

    abstract::This study describes the in vitro inhibition of protein denaturation of extract/fractions of Withania somnifera and isolated withanolides including 20β hydroxy-1-oxo(22R)-witha-2,5,24 trienolide (1), (20R,22R-14α,20α)-dihydroxy-1-oxowitha-2,5,16,24 tetraenolide (2). The results showed that the extract/fractions of the...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2015.1007138

    authors: Khan MA,Khan H,Rauf A,Ben Hadda T

    更新日期:2015-01-01 00:00:00

  • Undescribed benzophenone and xanthones from cave-derived Streptomyces sp. CB09001.

    abstract::A new benzophenone huanglongmycin (HLM) D (1) and two new monomeric xanthones huanglongmycin E (2) and F (3), together with four known aromatic polyketides aloesaponarin II (4) and the previously isolated huanglongmycin A-C (5-7) were obtained from cave-derived Streptomyces sp. CB09001. The structures of 1-3 were esta...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1813134

    authors: Jiang L,Xiang J,Zhu S,Tang D,Gong B,Pu H,Duan Y,Huang Y

    更新日期:2020-09-01 00:00:00

  • Extraction and partial characterisation of antioxidant pigment produced by Chryseobacterium sp. kr6.

    abstract::Pigments synthesised by Chryseobacterium sp. kr6 growing on feather waste were extracted and characterised. The pigment extract was characterised by KOH test, UV-vis, CIELAB colour system, HPLC-DAD-MS, FTIR and its antioxidant capacity was evaluated. A positive bathochromic shift was observed when kr6 colonies or pigm...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1423304

    authors: Jiménez MEP,Pinilla CMB,Rodrigues E,Brandelli A

    更新日期:2019-06-01 00:00:00

  • Polyphenolics from Gymnocarpos decandrus Forssk roots and their biological activities.

    abstract::Phytochemical investigation of Gymnocarpos decandrus roots lead to the isolation, characterization and evaluation of four compounds: the bis-coumarin daphnoretin, two biflavonoids: wikstrol A and wikstol B in addition to β-sitosterol glucoside. Their structures were established via spectroscopic data. The crude root e...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2019.1607336

    authors: Fathy H

    更新日期:2019-05-13 00:00:00

  • Chemical constituents of Geum urbanum L. roots.

    abstract::A new dehydrodigallic acid derivative (1), along with 19 known compounds, including 6 phenolic derivatives, 2 steroids and 11 triterpenoids were isolated from the ethanol extract of the root of Geum urbanum. Herein, there is the first report of steroid and triterpene in Geum urbanum. The purified metabolites were char...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2018.1425844

    authors: Ton That Q,Nguyen Thien TV,Dang HP,Le Hoan N,Vo LKT,Nguyen MHD,Ngu NT,Nguyen TS,Hansen PE

    更新日期:2018-11-01 00:00:00

  • Free radical-scavenging activities of Homalium species--An endangered medicinal plant of Eastern Ghats of India.

    abstract::Three species of the genus Homalium - e.g. Homalium nepalense, Homalium tomentosum and Homalium zeylanicum (Flacourtiaceae) - are recorded in India which are confined to the Eastern Ghat hill ranges. While H. zeylanicum is the IUCN red-listed medium-sized tree, the other two are endangered species of medicinal signifi...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2014.987142

    authors: Mahapatra AK,Pani SS,Sahoo AK

    更新日期:2015-01-01 00:00:00

  • Anticancer activity of oleiferoside B involving autophagy and apoptosis through increasing ROS release in MCF-7 cells and SMMC-7721 cells.

    abstract::Oleiferoside B is a triterpenoid monomer compound, mainly isolated from roots of Camellia oleifera Abel, the underlying mechanism of its antitumour is not clear. In the present study, oleiferoside B potently inhibited SMMC-7721 and MCF-7 cells proliferation and cause cells apoptosis. In addition, it activated an autop...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2020.1739039

    authors: Feng S,Zha Z,Wang Z,Yang P,Wu J,Li X,Xu Q,Liu Y

    更新日期:2020-03-18 00:00:00

  • A new labdane diterpenoid arabinoside from Conyza blinii.

    abstract::A new diterpenoid glycoside, 14,15-dinor-labdan-13-one-8-O-alpha-L-arabinopyranoside (1), was isolated from Conyza blinii. The structure of this new arabinoside was elucidated on the basis of extensive NMR and HRMS spectroscopy. In addition, the presence of 3R-hydroxyoctadecanoic acid in C. blinii was reported for the...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410701592232

    authors: Su Y,Chen L,Wang D,Chai X,Guo D

    更新日期:2008-04-15 00:00:00

  • Protein tyrosine phosphatase 1B inhibitory activity of cone oils from Juniperus chinensis cv. Kaizuca and in silico theoretical explanation.

    abstract::Juniperus chinensis cv. Kaizuca has extensive pharmacological activities. The cone oils exhibited protein tyrosine phosphatase 1B inhibitory activity in vitro. The IC50 value was 4.49 ± 0.04 μg/mL. A total of 17 compounds were characterised from the cone oils by GC-MS. In order to explain the activity against protein ...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1374267

    authors: Fang C,Gu D,Yang J,Li M,Liu H,Yang Y

    更新日期:2018-11-01 00:00:00

  • Biotransformation of the marine sesquiterpene pacifenol by a facultative marine fungus.

    abstract::Continued investigation of the marine alga Laurencia claviformis has led to the isolation of pacifenol, a halogenated sesquiterpene as the major metabolite. The microbial transformation of pacifenol is reported. It was cultivated with a marine strain of Penicillium brevicompactum yielding a new compound. The structure...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410701869440

    authors: San-Martín A,Rovirosa J,Astudillo L,Sepúlveda B,Ruiz D,San-Martín C

    更新日期:2008-12-01 00:00:00

  • A new insecticidal havanensin-type limonoid from the roots of Trichilia sinensis Bentv.

    abstract::One new havanensin-type limonoid (1) named trisinlin A with two known compounds (4E,8E)-2-[2'-hydroxyhexadecanoyl amino]-4,8-octadecadiene-1,3-diol (2), 9-octadecenoic acid-2',3'-dihydroxypropyl ester (3) were isolated from the roots of Trichilia sinensis. The structure of the new compound was unambiguously determined...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786419.2017.1380016

    authors: Liu SB,Chen HQ,Feng G,Guo ZK,Cai CH,Wang J,Mei WL,Dai HF

    更新日期:2018-12-01 00:00:00

  • Chemical composition, allelopatic and cytotoxic effects of essential oils of flowering tops and leaves of Crambe orientalis L. from Iran.

    abstract::Crambe orientalis L. (Brassicaceae), a perennial herb, is indigenous to Iran. The essential oils of flowering tops and leaves of the plant were evaluated by GC-MS. Our results showed that while 2-methyl-5-hexenitrile (19.5%) and benzyl cyanide (16.9%) were the major components of flowering tops oil, the oil of the lea...

    journal_title:Natural product research

    pub_type: 杂志文章

    doi:10.1080/14786410802611303

    authors: Razavi SM,Nejad-Ebrahimi S

    更新日期:2009-01-01 00:00:00