Anticancer effect of ethanol Lycium barbarum (Goji berry) extract on human breast cancer T47D cell line.

Abstract:

:The anticancer activity of ethanol extract isolated from Goji berry (EEGB) on T47D human breast cancer cell line has been reported. Cell viability and cell proliferation were examined with the use of BrdU, MTT and NR methods. Induction of apoptosis was assessed by propidium iodide and Hoechst 33342 staining. Expression of genes involved in cell proliferation, apoptosis, cell cycle control and regulation of transcription was estimated using Western blotting analysis. EEGB inhibited the proliferation of breast cancer cells in a time-, and dose-dependent manner. The study confirmed the lack of EEGB cytotoxic activity to normal human skin fibroblasts. Western blot analysis demonstrated an increase in pro-apoptotic and a decrease in anti-apoptotic proteins' expression in cells treated with the extract. Anticancer activity and lack of toxicity against normal cells indicate a chemopreventive potential of Goji berries in breast cancer treatment.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Wawruszak A,Czerwonka A,Okła K,Rzeski W

doi

10.1080/14786419.2015.1101691

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

1993-6

issue

17

eissn

1478-6419

issn

1478-6427

journal_volume

30

pub_type

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