Atheroprotective potentials of curcuminoids against ginger extract in hypercholesterolaemic rabbits.

Abstract:

:The anti-atherogenic potentials of total ginger (Zingiber officinale) extract (TGE) or curcuminoids extracted from turmeric (Curcuma longa), members of family Zingiberaceae, were compared in hypercholesterolaemia. Rabbits were fed either normal or atherogenic diet. The rabbits on atherogenic diet received treatments with TGE or curcumenoids and placebo concurrently for 6 weeks (n = 6). The anti-atherogenic effects of curcuminoids and ginger are mediated via multiple mechanisms. This effect was correlated with their ability to lower cholesteryl ester transfer protein activity. Ginger extract exerted preferential effects on plasma lipids, reverse cholesterol transport, cholesterol synthesis and inflammatory status. Curcuminoids, however, showed superior antioxidant activity.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Elseweidy MM,Younis NN,Elswefy SE,Abdallah FR,El-Dahmy SI,Elnagar G,Kassem HM

doi

10.1080/14786419.2014.957699

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

961-5

issue

10

eissn

1478-6419

issn

1478-6427

journal_volume

29

pub_type

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