Mass spectrometry-guided isolation of two new dihydrobenzophenanthridine alkaloids from Macleaya cordata.

Abstract:

:Two new alkaloids 6-hydroxyethyldihydrochelerythrine (1) and 6-hydroxymethyl-7,8-demethylenedihydrochelerythrine (2) together with two analogues named maclekarpine E (3) and 6-hydroxymethyldihydrosanguinarine (4) were detected primarily from the leaves of Macleaya cordata by their characteristic mass spectrometry (MS) and tandem mass spectrometry (MS/MS). And then isolation of four targeted-compounds was performed by column chromatography and preparation HPLC under the guiding of MS. Finally, their structures were determined by spectrum analysis. Alkaloids 3 and 4 were isolated from this plant medicine for the first time.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Qing ZX,Yang P,Yu K,Yang XY,Liu JH,Xiang F,Cao HL,Cheng P,Zeng JG

doi

10.1080/14786419.2017.1285300

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

1633-1639

issue

14

eissn

1478-6419

issn

1478-6427

journal_volume

31

pub_type

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