Abstract:
:Three new phenanthrenone constituents, trigoxyphins U-W (1, 7 and 9), together with eight known ones, trigoxyphin M (2), 6,9-O-dimethyltrigonostemone (3), trigonstemone (4), thrigonosomone B (5), trigonochinene E (6), actephiiol A (8), epiactephilol A (10) and neoboutomannin (11), were obtained from the methanol extract of the leaves and stems of Trigonostemonlii. The structures of the new metabolites were elucidated by analysing the spectroscopic data (1D NMR, 2D NMR, HR-ESI-MS and IR). Compounds 1-6 were evaluated for their cytotoxic activities on five human tumour cell lines by using the MTT method, and compound 1 exhibited inhibitory activity against HL-60, SMMC-7721, A-549, MCF-7 and SW480 with IC50 values ranging from 3.77 to 14.51 μM.
journal_name
Nat Prod Resjournal_title
Natural product researchauthors
Li SF,He HP,Hao XJdoi
10.1080/14786419.2015.1009066subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1845-9issue
19eissn
1478-6419issn
1478-6427journal_volume
29pub_type
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