Three new phenanthrenone constituents from Trigonostemon lii.

Abstract:

:Three new phenanthrenone constituents, trigoxyphins U-W (1, 7 and 9), together with eight known ones, trigoxyphin M (2), 6,9-O-dimethyltrigonostemone (3), trigonstemone (4), thrigonosomone B (5), trigonochinene E (6), actephiiol A (8), epiactephilol A (10) and neoboutomannin (11), were obtained from the methanol extract of the leaves and stems of Trigonostemonlii. The structures of the new metabolites were elucidated by analysing the spectroscopic data (1D NMR, 2D NMR, HR-ESI-MS and IR). Compounds 1-6 were evaluated for their cytotoxic activities on five human tumour cell lines by using the MTT method, and compound 1 exhibited inhibitory activity against HL-60, SMMC-7721, A-549, MCF-7 and SW480 with IC50 values ranging from 3.77 to 14.51 μM.

journal_name

Nat Prod Res

journal_title

Natural product research

authors

Li SF,He HP,Hao XJ

doi

10.1080/14786419.2015.1009066

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

1845-9

issue

19

eissn

1478-6419

issn

1478-6427

journal_volume

29

pub_type

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